Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00507
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| Drug Name |
Lomefloxacin
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| Synonyms |
(+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride; DM 10 (bactericide); DM-10; LFLX; Lomefloxacin (USAN); Lomefloxacin [USAN:BAN:INN]; Lomefloxacine; Lomefloxacine [French]; Lomefloxacino; Lomefloxacino [Spanish]; Lomefloxacinum; Lomefloxacinum[Latin]; Maxaquin (TN); Maxaquin (hydrochloride); NY-198 (hydrochloride); Okacyn (TN); SC 4711; SC 47111A; SC-4711; SC-47111 (hydrochloride); SC-47111A; SC-47111B (mesylate); Uniquin (TN)
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infections [ICD11:1A00-1H0Z] | Approved | [1] | |||
| Therapeutic Class |
Antibiotics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C17H19F2N3O3
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| Canonical SMILES |
CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O
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| InChI |
InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)
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| InChIKey |
ZEKZLJVOYLTDKK-UHFFFAOYSA-N
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| CAS Number |
CAS 98079-51-7
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| Pharmaceutical Properties | Molecular Weight | 351.35 | Topological Polar Surface Area | 72.9 | ||
| Heavy Atom Count | 25 | Rotatable Bond Count | 3 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 8 | |||
| XLogP |
-0.8
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| PubChem CID | ||||||
| PubChem SID |
103178831
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,11360779
,11364325
,11366887
,11369449
,11372706
,11373775
,11377611
,11461751
,11466266
,11467386
,11484587
,11485972
,11488512
,11491309
,11491973
,11495245
,14851991
,24278514
,29223062
,46508499
,47291062
,47588922
,47588923
,47736397
,47736398
,48035031
,48110376
,48334411
,48334412
,49698401
,49835841
,50042514
,50111115
,50122921
,50122922
,50203310
,5037068
,56313756
,57322062
,602955
,7849377
,7979788
,8152478
,85321506
,85788434
,90340951
,92309292
,9289
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| ChEBI ID |
CHEBI:116278
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | OATP1A2 | Transporter Info | Organic anion transporting polypeptide 1A2 | Substrate | [2] | |
| References | ||||||
| 1 | Lomefloxacin was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. | |||||
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