Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00499
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| Drug Name |
Corticosterone
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| Synonyms |
(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE; (11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione; 11,12-Dihydroxyprogesterone; 11,21-Dihydroxyprogesterone; 11-Hydroxycorticoaldosterone; 11-beta,21-Dihydroxypregn-3,20-dione; 11Beta,21-dihydroxypregn-4-ene-3,20-dione; 11beta,21-Dihydroxy-4-pregnene-3,20-dione; 11beta,21-Dihydroxyprogesterone; 17-Deoxycortisol; 4-Pregnene-11beta,21-diol-3,20-dione; 50-22-6; CCRIS 6753; CHEBI:16827; Compound B; Corticosteron; Corticosterone; Kendall's compound B; NSC9705; Reichstein's B; Reichstein's substance H; UNII-W980KJ009P
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| Drug Type |
Small molecular drug
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| Indication | Coxarthrosis [ICD11:FA00] | Phase 3 | [1] | |||
| Structure |
|
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| 3D MOL | 2D MOL | |||||
| Formula |
C21H30O4
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| Canonical SMILES |
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
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| InChI |
InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
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| InChIKey |
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
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| CAS Number |
CAS 50-22-6
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| Pharmaceutical Properties | Molecular Weight | 346.5 | Topological Polar Surface Area | 74.6 | ||
| Heavy Atom Count | 25 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
1.9
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| PubChem CID | ||||||
| PubChem SID |
10321632
,11466460
,11467580
,11486119
,17389502
,17404783
,24278302
,24856812
,24869860
,25630774
,26751495
,26758495
,29224789
,46386953
,46504547
,47275526
,47646532
,48018879
,48243330
,48318377
,48393901
,48393902
,48421980
,48424986
,49698488
,49956045
,50104040
,5219
,53777326
,53788667
,53834312
,56311825
,56312404
,56312772
,56313244
,56423132
,57322931
,57390013
,57648276
,57650717
,58685480
,6435953
,75084
,7886418
,7978988
,804393
,8143631
,8153530
,841767
,855741
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| ChEBI ID |
CHEBI:16827
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | ClinicalTrials.gov (NCT01079455) Comparison of Hyaluronic Acid and Corticosteroid Intra-articular Injections for the Treatment of Osteoarthritis of the Hip | |||||
| 2 | Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. | |||||
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