Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00497
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| Drug Name |
Desloratadine
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| Synonyms |
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine; 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Aerius; Aerius (TN); Allex; Azomyr; Claramax; Claramax (TN); Clarinex; Clarinex (TN); Clarinex RediTabs; Denosin; Desalex; Descarboethoxyloratadine; Descarboethoxyoratidine; Desloratadine (USAN/INN); Desloratadine [USAN]; Desloratidine; Essex brand of desloratadine; NeoClarityn (TN); Neoclarityn; Opulis; Sch 34117; Sch-34117; Schering brand of desloratadine; Schering-Plough brand of desloratadine
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| Drug Type |
Small molecular drug
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| Indication | Allergic rhinitis [ICD11:CA08.0] | Approved | [1] | |||
| Therapeutic Class |
Antiallergic Agents
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| Structure |
|
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| 3D MOL | 2D MOL | |||||
| Formula |
C19H19ClN2
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| Canonical SMILES |
C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
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| InChI |
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
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| InChIKey |
JAUOIFJMECXRGI-UHFFFAOYSA-N
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| CAS Number |
CAS 100643-71-8
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| Pharmaceutical Properties | Molecular Weight | 310.8 | Topological Polar Surface Area | 24.9 | ||
| Heavy Atom Count | 22 | Rotatable Bond Count | 0 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 2 | |||
| XLogP |
4.5
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| PubChem CID | ||||||
| PubChem SID |
10240975
,103341726
,103966640
,104420034
,104829344
,11528904
,117782347
,12013632
,124659138
,125325449
,125336452
,126584136
,126630167
,126656876
,126670272
,126728408
,128248166
,134337643
,134358654
,135078453
,135916143
,137001891
,142370109
,144076154
,14742700
,14874264
,17397787
,25623633
,26719697
,26754458
,29215232
,29215233
,29304216
,4480883
,46386563
,46507996
,49830094
,50086379
,515991
,53790902
,57340751
,75986670
,85209723
,85483828
,87561219
,92307949
,92308612
,92309042
,92712182
,93619677
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| ChEBI ID |
CHEBI:291342
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Desloratadine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos. 2003 Mar;31(3):312-8. | |||||
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