Drug Information

General Information
Drug ID
DR00494
Drug Name
Estrone
Synonyms
(13S)-3-hydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one; (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one;1,3,5(10)-Estratrien-3-ol-17-one; 1,3,5(10)-Oestratrien-3-ol-17-one; 3-Hydroxy-1,3,5(10)-estratrien-17-one; 3-Hydroxy-17-keto-estra-1,3,5-triene; 3-Hydroxy-17-keto-oestra-1,3,5-triene; 3-Hydroxy-oestra-1,3,5(10)-trien-17-one; 3-Hydroxyestra-1,3,5(10)-trien-17-one; 3-Hydroxyestra-1,3,5(10)-triene-17-one; 3-hydroxy-estra-1,3,5(10)-trien-17-one; Aquacrine; Crinovaryl; Cristallovar; Crystogen; Delta-1,3,5-Estratrien-3beta-ol-17-one; Delta-1,3,5-Oestratrien-3beta-ol-17-one; Delta-1,3,5-estratrien-3-beta-ol-17-one; Delta-1,3,5-oestratrien-3-beta-ol-17-one; Destrone; Disynformon; E 9750; E(sub 1); E0026; Endofolliculina; Esterone; Estrin; Estrogenic Substance; Estrol; Estron; Estrona; Estrona [INN-Spanish]; Estrona [Spanish]; Estrone (E1); Estrone (JAN/USP/INN); Estrone (TN); Estrone [USAN:INN]; Estrone, (+-)-Isomer; Estrone, (8 alpha)-Isomer; Estrone, (9 beta)-Isomer; Estrone-A; Estronum; Estronum [INN-Latin]; Estrovarin; Estrugenone; Estrusol; Fem-O-Gen; Femestrone inj.; Femestrone injection; Femidyn; Fermidyn; Folikrin; Folipex; Folisan; Follestrine; Follestrol; Follicular hormone; Folliculin; Folliculine; Folliculine benzoate; Follicunodis; Glandubolin; Hauck Brand of Estrone; Hiestrone; Hormestrin; Hormofollin; Hormovarine; Hyrex Brand of Estrone; Kestrone; Ketodestrin; Ketohydroxy-Estratriene; Ketohydroxyestrin; Ketohydroxyoestrin; Ketophydroxyestrin; Kolpon; Menagen; Menformon; Menformon A; Mestronaq; NATURAL ESTROGENIC SUBSTANCE-ESTRONE; OESTRONE; Oestrin; Oestroform;Oestronum; Oestrone [Steroidal oestrogens]; Oestrone, Estrone; Oestroperos; Ovex (tablets); Ovifollin; Penncap M; Perlatan; Solliculin; Theelin; Thelestrin; Thelykinin; Thynestron; Tokokin; Unden; Unden (pharmaceutical); Unden (pharmaceutical) (VAN); Unigen; Vortech Brand of Estrone; Wehgen; Wynestron; WynestronPencap M;CMC_13458; [2,4,6,7-3H]-E1
Drug Type
Small molecular drug
Indication Postmenopausal disorder [ICD11:GA30.Z] Approved [1]
Therapeutic Class
Antimenopausal Agents
Structure
3D MOL 2D MOL
Formula
C18H22O2
Canonical SMILES
CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O
InChI
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
InChIKey
DNXHEGUUPJUMQT-CBZIJGRNSA-N
CAS Number
CAS 53-16-7
Pharmaceutical Properties Molecular Weight 270.4 Topological Polar Surface Area 37.3
Heavy Atom Count 20 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
XLogP
3.1
PubChem CID
5870
PubChem SID
11466942 ,11468062 ,11486713 ,14714953 ,14750534 ,14774967 ,17405076 ,24278427 ,24715020 ,24870303 ,24894399 ,26512283 ,26751561 ,26751562 ,2687 ,29224898 ,3133155 ,3751 ,46505916 ,46517467 ,47213246 ,47275539 ,47424227 ,47646545 ,47646546 ,47646547 ,47720600 ,47943749 ,48094530 ,48243347 ,48318399 ,48421873 ,49684201 ,49699003 ,49965933 ,50104169 ,50104170 ,50124146 ,50124147 ,50124148 ,50967133 ,53777619 ,53787846 ,613807 ,7847135 ,7979191 ,8144215 ,8153628 ,841396 ,855919
ChEBI ID
ChEBI:17263
TTD Drug ID
D00ZFP
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Estrone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93.

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