Drug Information

General Information
Drug ID
DR00484
Drug Name
Pimozide
Synonyms
1-(1-(4,4-Bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone; 1-(4,4-Bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine; 1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone; 1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine; 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one; 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one; 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one; ASTA Medica Brand of Pimozide; Antalon; Janssen Brand of Pimozide;Orap forte; McN-JR 6238; McN-JR-6238; Neoperidole; Opiran; Orap; Orap (TN); P 1793; Pharmascience Brand of Pimozide; Pimozida; Pimozida [INN-Spanish]; Pimozide (JAN/USP/INN); Pimozide [USAN:INN:BAN:JAN]; Pimozidum; Pimozidum [INN-Latin]; Primozida; Primozida [INN-Spanish]; R 6238; R-6238
Drug Type
Small molecular drug
Indication Schizophrenia [ICD11:6A20] Approved [1]
Therapeutic Class
Antipsychotic Agents
Structure
3D MOL 2D MOL
Formula
C28H29F2N3O
Canonical SMILES
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
InChI
InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
InChIKey
YVUQSNJEYSNKRX-UHFFFAOYSA-N
CAS Number
CAS 2062-78-4
Pharmaceutical Properties Molecular Weight 461.5 Topological Polar Surface Area 35.6
Heavy Atom Count 34 Rotatable Bond Count 7
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
XLogP
6.3
PubChem CID
16362
PubChem SID
10321421 ,11111615 ,11112507 ,11113804 ,11335561 ,11360800 ,11363339 ,11365901 ,11368463 ,11372540 ,11373859 ,11376625 ,11447004 ,11461772 ,11466336 ,11467456 ,11484947 ,11486231 ,11488842 ,11491266 ,11492235 ,11494259 ,12013418 ,14882544 ,17405504 ,24277923 ,26612186 ,26680826 ,26747138 ,26747139 ,26751488 ,26751978 ,26751979 ,29284219 ,46507096 ,47275121 ,47275122 ,47423792 ,47572947 ,47720184 ,47720185 ,563187 ,6706026 ,7847626 ,7980325 ,8137196 ,8149730 ,8162258 ,855710 ,9769
ChEBI ID
ChEBI:8212
TTD Drug ID
D00KHM
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Pimozide was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.

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