Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00470
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| Drug Name |
Amitriptyline
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| Synonyms |
10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(5),gamma-propylamine; 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene; 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin; 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine; 5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene; 5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene; 5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene; 5-(3-dimethylaminopropylidene)dibenzo[a,d][1,4]-cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene; 5-(gamma-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo[a,d]10,11-dihydrocycloheptene; 5-(gamma-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene; Adepress; Adepril; Amitril; Amitriprolidine; Amitriptilina; Amitriptilina [INN-Spanish]; Amitriptilina [Italian]; Amitriptylin; Amitriptylin [German]; Amitriptyline (INN); Amitriptyline [INN:BAN]; Amitriptylinum; Amitriptylinum [INN-Latin]; Amitryptiline; Amitryptyline; Amytriptiline; Amytriptylin; Damilan; Damilen; Damitriptyline; Elanil; Elavil; Elavil (TN); Flavyl; Lantron; Laroxil; Laroxyl; Laroxyl (TN); MK 230; N 750; Proheptadiene; Redomex; Ro 4-1575; Sarotex; Seroten; Sylvemid; TP0; Triptanol; Triptilin; Triptisol; Tryptanol; [3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine
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| Drug Type |
Small molecular drug
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| Indication | Major depressive disorder [ICD11:6A70.3] | Approved | [1] | |||
| Therapeutic Class |
Analgesics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C20H23N
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| Canonical SMILES |
CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
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| InChI |
InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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| InChIKey |
KRMDCWKBEZIMAB-UHFFFAOYSA-N
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| CAS Number |
CAS 50-48-6
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| Pharmaceutical Properties | Molecular Weight | 277.4 | Topological Polar Surface Area | 3.2 | ||
| Heavy Atom Count | 21 | Rotatable Bond Count | 3 | |||
| Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 1 | |||
| XLogP |
5
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| PubChem CID | ||||||
| PubChem SID |
10524415
,10589138
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,11110783
,11335941
,11361180
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,11364675
,11365400
,11367237
,11367962
,11369799
,11371436
,11372840
,11373731
,11375399
,11376124
,11377962
,11462152
,11466102
,11467222
,11483818
,11485944
,11487917
,11490114
,11491961
,11493858
,11534105
,14775196
,29221339
,4426037
,46508798
,47291168
,47440289
,47440290
,47589029
,47662314
,47662315
,47662316
,47736512
,48035153
,48185028
,48334525
,48334526
,48415554
,597372
,7978691
,8151468
,841048
,9042
|
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| ChEBI ID |
ChEBI:2666
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Amitriptyline was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. | |||||
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