Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00467
|
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| Drug Name |
Morphine
|
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| Synonyms |
Astramorph Pf; Avinza; Depodur; Duramorph Pf; Infumorph; Kadian; Morphine Sulfate; Ms Contin; Oramorph Sr
|
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| Drug Type |
Small molecular drug
|
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| Indication | Chronic pain [ICD11:MG30] | Approved | [1] | |||
| Therapeutic Class |
Analgesics
|
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| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
C17H19NO3
|
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| Canonical SMILES |
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
|
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| InChI |
InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
|
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| InChIKey |
BQJCRHHNABKAKU-KBQPJGBKSA-N
|
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| CAS Number |
CAS 57-27-2
|
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| Pharmaceutical Properties | Molecular Weight | 285.34 | Topological Polar Surface Area | 52.9 | ||
| Heavy Atom Count | 21 | Rotatable Bond Count | 0 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
0.8
|
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| PubChem CID | ||||||
| PubChem SID |
103169185
,103914789
,11041479
,126677732
,127553079
,127829358
,134337399
,134970862
,135650624
,137003124
,137178956
,139157571
,14775492
,14897787
,152105973
,160963643
,175268905
,175442171
,179150686
,223674390
,223677431
,223738295
,226395290
,241102130
,39321145
,46394454
,46505161
,4681
,48416295
,49992759
,53788344
,56312319
,56312595
,56313877
,57359248
,597738
,7888991
,79236356
,7980017
,8017560
,8144201
,841232
,87544101
,93166305
,96024921
|
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| ChEBI ID |
ChEBI:17303
|
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | MRP3 | Transporter Info | Multidrug resistance-associated protein 3 | Substrate | [2] | |
| P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [3] | ||
| References | ||||||
| 1 | Morphine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73. | |||||
| 3 | Genetic variability and clinical efficacy of morphine. Acta Anaesthesiol Scand. 2005 Aug;49(7):902-8. | |||||
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