Drug Information

General Information
Drug ID
DR00464
Drug Name
Anastrozole
Synonyms
1,3-benzenediacetonitrile, a, a,a', a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl); 2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile); 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile); 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)benzene-1,3-diyl]bis(2-methylpropanenitrile); 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile; Alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile; Alpha,alpha,alpha',alpha'-tetramethyl-5(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile; Anastrazole; Anastrole; Anastrozol; Anastrozole (JAN/USAN/INN); Anastrozole [USAN:INN:BAN]; Arimidex; Arimidex (TN); Arimidex (Zeneca); Arimidex, Anastrozole; Asiolex; Astra brand of anastrozole; AstraZeneca brand of anastrozole; ZD 1033; ZD-1033; ZD1033; Zeneca ZD 1033; Zeneca brand of anastrozole
Drug Type
Small molecular drug
Indication Breast cancer [ICD11:2C60-2C6Z] Approved [1]
Therapeutic Class
Anticancer Agents
Structure
3D MOL 2D MOL
Formula
C17H19N5
Canonical SMILES
CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N
InChI
InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3
InChIKey
YBBLVLTVTVSKRW-UHFFFAOYSA-N
CAS Number
CAS 120511-73-1
Pharmaceutical Properties Molecular Weight 293.4 Topological Polar Surface Area 78.3
Heavy Atom Count 22 Rotatable Bond Count 4
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 4
XLogP
2.1
PubChem CID
2187
PubChem SID
103478231 ,10359 ,104299862 ,11528617 ,117672710 ,118313740 ,12014321 ,124659088 ,124757065 ,124801312 ,125163869 ,125311691 ,125339200 ,126630179 ,126657740 ,126667645 ,129769972 ,131296284 ,134337917 ,135018130 ,135698190 ,135727309 ,136348802 ,14751420 ,26719808 ,26758041 ,29221365 ,46386543 ,46504987 ,46510669 ,48415567 ,49681575 ,5128740 ,53007586 ,535026 ,53789173 ,56311273 ,56313558 ,56313576 ,57321190 ,58106884 ,7848023 ,7978492 ,81040864 ,8151486 ,87351875 ,92308653 ,92308946 ,92712142 ,99436928
ChEBI ID
CHEBI:2704
TTD Drug ID
D0W0BF
DT(s) Transporting This Drug SNAT7 Transporter Info Putative sodium-coupled neutral amino acid transporter 7 Substrate [2]
References
1 Anastrozole was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2. Clin Pharmacol Ther. 2019 Jan 16.

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