Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00449
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| Drug Name |
Hydroxychloroquine
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| Synonyms |
2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol; 2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol; 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol; 2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol; 7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline; 7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline; 7-Chloro-4-(5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl)aminoquinoline; Gen-Hydroxychloroquine 200mg Tablets; HCQ; Hidroxicloroquina; Hidroxicloroquina [INN-Spanish]; Hydroxychlorochin; Hydroxychloroguine; Hydroxychloroquine (INN);Hydroxychloroquine [INN:BAN]; Hydroxychloroquine Sulfate (1:1) Salt; Hydroxychloroquinum; Hydroxychloroquinum [INN-Latin]; Idrossiclorochina; Idrossiclorochina [DCIT]; Oxichlorochinum; Oxichloroquine; Oxychlorochin; Oxychloroquine; Plaquenil (TN); Polirreumin; Polirreumin (TN); Quensyl; WIN 1258
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD11:1F40] | Approved | [1] | |||
| Therapeutic Class |
Antimalarials
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| Structure |
|
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| 3D MOL | 2D MOL | |||||
| Formula |
C18H26ClN3O
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| Canonical SMILES |
CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
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| InChI |
InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)
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| InChIKey |
XXSMGPRMXLTPCZ-UHFFFAOYSA-N
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| CAS Number |
CAS 118-42-3
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| Pharmaceutical Properties | Molecular Weight | 335.9 | Topological Polar Surface Area | 48.4 | ||
| Heavy Atom Count | 23 | Rotatable Bond Count | 9 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
3.6
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| PubChem CID | ||||||
| PubChem SID |
103566848
,104304133
,10505161
,11336117
,11361356
,11462328
,11484852
,11489054
,118262645
,124573764
,126687853
,129756062
,134338155
,134973873
,135702786
,136890426
,137083308
,143201344
,143401603
,14777730
,160964848
,162180925
,163835395
,163836798
,165716210
,172829147
,174006176
,175607648
,177748295
,178103773
,179039315
,29215442
,29222777
,3140459
,46508459
,47662363
,47885484
,48416094
,49967663
,5137975
,57321921
,597669
,75004190
,7979547
,8150104
,8152307
,85286187
,9255
,96024743
,99302030
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| ChEBI ID |
ChEBI:5801
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | BCRP | Transporter Info | Breast cancer resistance protein | Substrate | [2] | |
| References | ||||||
| 1 | Hydroxychloroquine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | MDR-ABC transporters: biomarkers in rheumatoid arthritis. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):779-87. | |||||
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