Drug Information

General Information
Drug ID
DR00444
Drug Name
Adefovir dipivoxil
Synonyms
(((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) 2,2-dimethylpropanoate; ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid, diester with hydroxymethyl pivalate; 9-(2-((-Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; 9-(2-((Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; ADV; Adefovir depivoxil; Adefovir dipivoxil (USAN); Adefovir pivoxil; Adefovir pivoxil (JAN); Adefovirdipivoxl; Bis(POM)-PMEA; Bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine; Bis(pom)PMEA; Bis-POM PMEA; Bis-POM PMEA, Adefovir Dipivoxil; Bis-POM PMEA, Preveon, Hepsera, Adefovir Dipivoxil; GS 0840; GS 840;Piv2PMEA; GS-0840; GS-840; Hepsera; Hepsera (TM); Hepsera (TN); Preveon; Preveon (TN); Propanoic acid, 2,2-dimethyl-, (((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) ester; Propanoic acid,2,2-dimethyl-(((2-(6-amino-9H-purin-9-yl)ehtoxy)mehtyl)phosphinyldiene)bis(oxymehtylene)ester; YouHeDing; [2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
Drug Type
Small molecular drug
Therapeutic Class
Antiviral Agents
Structure
3D MOL 2D MOL
Formula
C20H32N5O8P
Canonical SMILES
CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C
InChI
InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
InChIKey
WOZSCQDILHKSGG-UHFFFAOYSA-N
CAS Number
CAS 142340-99-6
Pharmaceutical Properties Molecular Weight 501.5 Topological Polar Surface Area 167
Heavy Atom Count 34 Rotatable Bond Count 15
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 12
XLogP
1.8
PubChem CID
60871
PubChem SID
103240599 ,104253333 ,104321855 ,109692937 ,11528768 ,118048871 ,119525323 ,12014790 ,124757452 ,125164256 ,125340236 ,126592990 ,126630083 ,126656634 ,126665844 ,129613204 ,131298815 ,134222429 ,134337388 ,134338819 ,134340371 ,135018282 ,135565514 ,135692243 ,135727110 ,136345656 ,136368131 ,136946538 ,136949103 ,137006009 ,142181502 ,143493341 ,144115540 ,144180310 ,144205796 ,14908863 ,152242352 ,26758046 ,43118206 ,46507520 ,49830940 ,57314164 ,612309 ,71824987 ,74485826 ,7848718 ,8187107 ,87244050 ,87245424 ,92712536
TTD Drug ID
D0ML1F

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