Drug Information

General Information
Drug ID
DR00438
Drug Name
Prednisone
Synonyms
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione; (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione; (8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione; 1,2-Dehydrocortisone; 1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione; 1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione; 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione; 1-Cortisone; 1-Dehydrocortisone; 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione; 17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione; Adasone; Ancortone; Apo-Prednisone; Bicortone; Cartancyl; Colisone; Cortan; Cortidelt; Cotone; Dacorten; Dacortin; Decortancyl; Decortin; Decortisyl; Dehydrocortisone; Dekortin; Dellacort; Dellacort A; Delta E; Delta E.; Delta cortelan; Delta(sup 1)-Cortisone; Delta(sup 1)-Dehydrocortisone; Delta(sup1)-Cortisone; Delta-1-Cortisone; Delta-1-Dehydrocortisone; Delta-Cortelan; Delta-Cortisone; Delta-Cortone; Delta-Dome; Delta-E; Delta1-Cortisone; Delta1-Dehydrocortisone; Deltacortene; Deltacortisone; Deltacortone; Deltasone; Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone; Deltison; Deltisona; Deltisone; Deltra; Di-Adreson; Diadreson; Econosone; Encorton; Encortone; Enkortolon; Enkorton; Fiasone; Hostacortin; In-Sone; Incocortyl; Juvason; Kortancyl; Liquid Pred; Lisacort; Lodotra; Me-Korti; Metacortandracin; Meticortelone (TN); Meticorten; Meticorten (TN); Meticorten (Veterinary); Metrevet (Veterinary); Nisona; Nizon; Novoprednisone; Nurison; Orasone; Origen Prednisone; P1276; Panafcort; Panasol; Paracort; Parmenison; Pehacort; Precort; Predeltin; Prednicen-M; Prednicorm; Prednicort; Prednicot; Prednidib; Prednilonga; Prednison; Prednisona; Prednisona [INN-Spanish]; Prednisone Intensol; Prednisone [INN:BAN]; Prednisonum; Prednisonum [INN-Latin]; Prednitone; Prednizon; Prednovister; Presone; Pronison; Pronisone; Rectodelt; Retrocortine; SK-Prednisone; Servisone; Sone; Sterapred; Supercortil; U 6020; Ultracorten; Ultracortene; Winpred; Wojtab; Zenadrid; Zenadrid (veterinary); Zenadrid [veterinary]
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD11:9B72] Approved [1]
Therapeutic Class
Antiinflammatory Agents
Structure
3D MOL 2D MOL
Formula
C21H26O5
Canonical SMILES
CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
InChI
InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
InChIKey
XOFYZVNMUHMLCC-ZPOLXVRWSA-N
CAS Number
CAS 53-03-2
Pharmaceutical Properties Molecular Weight 358.4 Topological Polar Surface Area 91.7
Heavy Atom Count 26 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
XLogP
1.5
PubChem CID
5865
PubChem SID
10321430 ,11404403 ,11466105 ,11467225 ,11485950 ,12159191 ,14876665 ,14901277 ,17389753 ,24887849 ,24898748 ,29224894 ,46508166 ,47423771 ,47499091 ,47869192 ,47943330 ,48094072 ,48168897 ,48393454 ,48414367 ,48423989 ,48425558 ,49681504 ,49698331 ,49855473 ,50085971 ,50105442 ,50105443 ,50793118 ,53790481 ,56310878 ,56312053 ,56312061 ,56312554 ,56314869 ,56320929 ,56320930 ,56352934 ,56463357 ,57323004 ,6436730 ,75351 ,7980378 ,81093202 ,811678 ,8153624 ,85300843 ,85787889 ,9574
ChEBI ID
ChEBI:8382
TTD Drug ID
D0IL7L
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Prednisone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803.

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