Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00395
|
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| Drug Name |
Carbamazepine
|
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| Synonyms |
Carbamazepine (iv, epilepsy); Carbamazepine (iv, epilepsy), Lundbeck; Carbamazepine (iv, epilepsy), Ovation Pharmaceuticals
|
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| Drug Type |
Small molecular drug
|
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| Indication | Epilepsy [ICD11:8A6Z] | Approved | [1] | |||
| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
C15H12N2O
|
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| Canonical SMILES |
C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
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| InChI |
InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
|
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| InChIKey |
FFGPTBGBLSHEPO-UHFFFAOYSA-N
|
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| CAS Number |
CAS 298-46-4
|
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| Pharmaceutical Properties | Molecular Weight | 236.27 | Topological Polar Surface Area | 46.3 | ||
| Heavy Atom Count | 18 | Rotatable Bond Count | 0 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 1 | |||
| XLogP |
2.5
|
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| PubChem CID | ||||||
| PubChem SID |
10321205
,10517602
,11109646
,11110939
,11110940
,11207111
,11335563
,11338925
,11360802
,11362930
,11365492
,11368054
,11371249
,11373863
,11376216
,11461774
,11466080
,11467200
,11483906
,11485860
,11487941
,11490141
,11492077
,11493910
,11514284
,14847331
,17389547
,17404855
,24278084
,24893120
,26611636
,26679702
,26747063
,26747064
,26751576
,29221715
,3154113
,442467
,46507583
,47216705
,47365117
,5051955
,621391
,7847318
,7978855
,8149231
,8151689
,855967
,866528
,9085
|
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| ChEBI ID |
CHEBI:3387
|
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | MRP2 | Transporter Info | Multidrug resistance-associated protein 2 | Substrate | [2] | |
| References | ||||||
| 1 | Carbamazepine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy. Pharmacogenet Genomics. 2010 Apr;20(4):249-56. | |||||
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