Drug Information

General Information
Drug ID
DR00384
Drug Name
Risperidone
Synonyms
3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one; 3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperi-dino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one; 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one; 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one; 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; Belivon; Consta, Risperdal; KS-1106; R 62 766; R 64 766, Risperdal, Risperidone; R 64,766; R 64766; R-118; R-64,766; R-64-766; R-64766; R64,766; R64766; Risperdal; Risperdal (TN); Risperdal Consta; Risperdal M-Tab; Risperdone; Risperidal; Risperidal M-Tab; Risperidona; Risperidona [Spanish]; Risperidone (JAN/USAN/INN); Risperidone (RIS); Risperidone [USAN:BAN:INN]; Risperidone, placebo; Risperidonum; Risperidonum [Latin]; Risperin; Rispolept; Rispolin; Sequinan
Drug Type
Small molecular drug
Indication Schizophrenia [ICD11:6A20] Approved [1]
Therapeutic Class
Antipsychotic Agents
Structure
3D MOL 2D MOL
Formula
C23H27FN4O2
Canonical SMILES
CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
InChI
InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChIKey
RAPZEAPATHNIPO-UHFFFAOYSA-N
CAS Number
CAS 106266-06-2
Pharmaceutical Properties Molecular Weight 410.5 Topological Polar Surface Area 61.9
Heavy Atom Count 30 Rotatable Bond Count 4
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 6
XLogP
2.7
PubChem CID
5073
PubChem SID
103170825 ,103856459 ,103914673 ,103916252 ,11111724 ,11111725 ,11467057 ,11468177 ,11486814 ,11528727 ,12013967 ,14904216 ,17405630 ,25819945 ,26719830 ,26753640 ,29224142 ,46386613 ,46505850 ,49658633 ,49666400 ,49681677 ,49699257 ,49830253 ,50106974 ,50106975 ,50123965 ,53778180 ,53790689 ,57322595 ,631811 ,7379882 ,7847492 ,7980523 ,80652519 ,81092846 ,8153122 ,85089206 ,85170980 ,85209258 ,85231208 ,85788353 ,89736125 ,92126063 ,92303273 ,92308377 ,92308738 ,92712792 ,93166420 ,93617025
ChEBI ID
ChEBI:8871
TTD Drug ID
D01AZG
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
Drug-Transporter Activity Data
Drug-Transporter Activity Data P-GP Transporter Info Km =12.4 microM Baculovirus-infected insect cells-MDR1 [3]
References
1 Risperidone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition. Clin Pharmacol Ther. 2005 Jul;78(1):43-51.
3 In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 2002 May 31;71(2):163-9.

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