Drug Information

General Information
Drug ID
DR00347
Drug Name
Olmesartan medoxomil
Synonyms
Benevas; Benicar; Benicar (TN); Benicar, Olmetec,Olmesartan; Berlin-Chemie Brand of Olmesartan Medoxomil; Forest Brand of Olmesartan Medoxomil; Olmesartan medoximil; Olmesartan medoxomil (JAN/USAN); Olmetec; Olmetec (TN); Olvance; Sankyo Brand of Olmesartan Medoxomil
Drug Type
Small molecular drug
Indication High blood pressure [ICD11:BA00] Approved [1]
Therapeutic Class
Antihypertensive Agents
Structure
3D MOL 2D MOL
Formula
C29H30N6O6
Canonical SMILES
CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O
InChI
InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)
InChIKey
UQGKUQLKSCSZGY-UHFFFAOYSA-N
CAS Number
CAS 144689-63-4
Pharmaceutical Properties Molecular Weight 558.6 Topological Polar Surface Area 154
Heavy Atom Count 41 Rotatable Bond Count 11
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 10
XLogP
3.8
PubChem CID
130881
PubChem SID
10242742 ,103770675 ,104253234 ,104373834 ,11364900 ,11367462 ,11370024 ,11372810 ,11374179 ,11378194 ,11484167 ,11488322 ,11491491 ,11492555 ,11495758 ,11528908 ,12014934 ,124637431 ,124757358 ,124891848 ,125164162 ,125311925 ,125341111 ,126624592 ,126655597 ,126655871 ,126669975 ,14935211 ,26612826 ,26681017 ,26748978 ,26748979 ,29309387 ,48185250 ,48334789 ,53789233 ,57343590 ,7300489 ,7848267 ,78528258 ,81040868 ,81092830 ,85209756 ,85787984 ,92124799 ,92308046 ,92308894 ,92713789 ,93302267 ,93815139
ChEBI ID
CHEBI:31932
TTD Drug ID
D07UBG
DT(s) Transporting This Drug BCRP Transporter Info Breast cancer resistance protein Substrate [2]
MRP2 Transporter Info Multidrug resistance-associated protein 2 Substrate [3]
MRP4 Transporter Info Multidrug resistance-associated protein 4 Substrate [3]
OAT1 Transporter Info Organic anion transporter 1 Substrate [3]
OAT3 Transporter Info Organic anion transporter 3 Substrate [3]
OATP1B1 Transporter Info Organic anion transporting polypeptide 1B1 Substrate [4]
OATP1B3 Transporter Info Organic anion transporting polypeptide 1B3 Substrate [3]
P-GP Transporter Info P-glycoprotein 1 Substrate [5]
Drug-Transporter Activity Data
Drug-Transporter Activity Data MRP2 Transporter Info Km =14.9 microM LLC-PK1 cells-MRP2 [3]
MRP4 Transporter Info Km =26.2 microM LLC-PK1 cells-MRP4 [3]
OAT1 Transporter Info Km =0.0683 microM Human embryonic kidney cells (HEK293)-OAT1 [3]
OAT3 Transporter Info Km =0.12 microM Human embryonic kidney cells (HEK293)-OAT3 [3]
OATP1B1 Transporter Info Km =12.8 microM Human embryonic kidney cells (HEK293)-OATP1B1 [3]
OATP1B1 Transporter Info Km =42.6 microM Oocytes-OATP1B1 [4]
OATP1B3 Transporter Info Km =44.2 microM Human embryonic kidney cells (HEK293)-OATP1B3 [3]
OATP1B3 Transporter Info Km =71.8 microM Oocytes-OATP1B3 [4]
References
1 Olmesartan medoxomil was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913)
3 Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76.
4 OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos. 2006 May;34(5):862-9.
5 KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665)

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