Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00300
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| Drug Name |
Fostamatinib
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| Synonyms |
901119-35-5; Fostamatinib [USAN:INN]; R 788; R-788; R-788 Free acid; R-935788 Free acid; R788; R7935788; SQ8A3S5101; Tavalisse; UNII-SQ8A3S5101
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| Drug Type |
Small molecular drug
|
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| Indication | Rheumatoid arthritis [ICD11:FA20] | Approved | [1] | |||
| Structure |
|
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| 3D MOL | 2D MOL | |||||
| Formula |
C23H26FN6O9P
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| Canonical SMILES |
CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C
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| InChI |
InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)
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| InChIKey |
GKDRMWXFWHEQQT-UHFFFAOYSA-N
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| CAS Number |
CAS 901119-35-5
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| Pharmaceutical Properties | Molecular Weight | 580.5 | Topological Polar Surface Area | 187 | ||
| Heavy Atom Count | 40 | Rotatable Bond Count | 10 | |||
| Hydrogen Bond Donor Count | 4 | Hydrogen Bond Acceptor Count | 15 | |||
| XLogP |
1.6
|
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| PubChem CID | ||||||
| PubChem SID |
124360793
,125164706
,125299332
,126665637
,134338877
,135262180
,135693729
,136367938
,137245316
,141853032
,144115995
,152159558
,152344305
,160681714
,162038039
,164043535
,164160256
,16775273
,170501470
,172087031
,172818901
,174006453
,174531355
,185997057
,188941735
,198973453
,206261469
,210274820
,210280453
,223366127
,223388366
,223684830
,227435155
,23769915
,242060176
,246229128
,251971029
,252215442
,75389485
,96026027
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | ABCB5 | Transporter Info | ATP-binding cassette sub-family B member 5 | Substrate | [2] | |
| References | ||||||
| 1 | Fostamatinib was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB12010) | |||||
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