Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00281
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| Drug Name |
Progesterone
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| Synonyms |
LPCN-1107; Progesterone (oral, preterm labor); Progesterone (oral, preterm labor), Lipocine
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| Drug Type |
Small molecular drug
|
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| Indication | Premature labour [ICD11:JB00] | Approved | [1] | |||
| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C21H30O2
|
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| Canonical SMILES |
CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
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| InChI |
InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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| InChIKey |
RJKFOVLPORLFTN-LEKSSAKUSA-N
|
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| CAS Number |
CAS 57-83-0
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| Pharmaceutical Properties | Molecular Weight | 314.5 | Topological Polar Surface Area | 34.1 | ||
| Heavy Atom Count | 23 | Rotatable Bond Count | 1 | |||
| Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 2 | |||
| XLogP |
3.9
|
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| PubChem CID | ||||||
| PubChem SID |
10318966
,10321434
,110315
,11446518
,11466505
,11467625
,11486289
,12015027
,14850243
,14874443
,17388760
,17389514
,17405453
,24278618
,24870355
,24898476
,24898649
,24898857
,24898978
,24899064
,25621439
,26715972
,26719639
,26746572
,26751485
,26751486
,26759395
,29204503
,29225009
,3139517
,3700
,46386909
,46391718
,46392093
,625872
,6435812
,6436726
,6436727
,75083
,7847134
,7890619
,7980395
,8026442
,8144717
,8153728
,818903
,834065
,837053
,841781
,855688
|
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| ChEBI ID |
CHEBI:17026
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | BCRP | Transporter Info | Breast cancer resistance protein | Substrate | [2] | |
| P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [3] | ||
| Drug-Transporter Activity Data | ||||||
| Drug-Transporter Activity Data | P-GP | Transporter Info | Km =30 microM | Chinese hamster ovary AA8 cells-MDR1 | [4] | |
| P-GP | Transporter Info | Km =53.6 microM | High five cells-MDR1 | [3] | ||
| References | ||||||
| 1 | Progesterone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. | |||||
| 3 | Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. | |||||
| 4 | Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. | |||||
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