Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00267
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| Drug Name |
Indomethacin
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| Synonyms |
Aconip; Aconip (TN); Amuno; Apo-Indomethacin; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Bonidon Gel; Catlep; Chibro-amuno; Chrono-indicid; Chrono-indocid; Confortid; DESMETHYL INDOMETHACIN; Dolcidium; Dolcidium PL;Flexin continus; Dolovin; Durametacin; Elmetacin; Hicin; I 7378; IMN; IN1454; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indo-Lemmon; Indo-Spray; Indo-phlogont; Indo-rectolmin; Indo-tablinen; Indochron E-R (TN); Indocid; Indocid (TN); Indocid (pharmaceutical); Indocid Pda; Indocid Sr; Indocin; Indocin (TN); Indocin I.V; Indocin I.V.; Indocin Sr; Indocin-SR (TN); Indolar SR; Indomecol; Indomed; Indomee; Indomet 140; Indometacin; Indometacin (JP15/INN); Indometacina; Indometacina [INN-Spanish]; Indometacine; Indometacine [INN-French]; Indometacinum; Indometacinum [INN-Latin]; Indometacyna; Indometacyna [Polish]; Indomethacin & MAP-30; Indomethacin (USP); Indomethacin [USAN:BAN]; Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethegan; Indomethine; Indometicina; Indometicina [Spanish]; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Inteban sp; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Mezolin; Miametan; Mikametan; Mobilan; Novo-Methacin; Novomethacin; Reumacide; Rhemacin LA; Rheumacin LA; Sadoreum; Tannex; Vonum
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| Drug Type |
Small molecular drug
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| Indication | Moderate to severe rheumatoid arthritis [ICD11:FA20] | Approved | [1] | |||
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C19H16ClNO4
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| Canonical SMILES |
CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
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| InChI |
InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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| InChIKey |
CGIGDMFJXJATDK-UHFFFAOYSA-N
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| CAS Number |
CAS 53-86-1
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| Pharmaceutical Properties | Molecular Weight | 357.8 | Topological Polar Surface Area | 68.5 | ||
| Heavy Atom Count | 25 | Rotatable Bond Count | 4 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
4.3
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| PubChem CID | ||||||
| PubChem SID |
10321568
,10525985
,11111328
,11111329
,11113361
,11121750
,11122230
,11335446
,11360685
,11362903
,11363813
,11365465
,11366375
,11368027
,11368937
,11370997
,11370998
,11371496
,11373534
,11373628
,11376189
,11377099
,11404374
,11446060
,11461657
,11466300
,11467420
,11484715
,11486099
,11488786
,11490284
,11491833
,11494733
,3225554
,5032
,5208606
,611045
,612102
,6435989
,7847209
,7888379
,7979604
,8027945
,8027950
,8027958
,8149387
,8152346
,832223
,841055
,856012
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| ChEBI ID |
ChEBI:49662
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Indomethacin was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1. Br J Cancer. 2007 Oct 22;97(8):1077-83. | |||||
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