Drug Information

General Information
Drug ID
DR00265
Drug Name
Lenvatinib
Synonyms
4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamide; E-7080, E7080; E7080
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD11:2C73] Approved [1]
Therapeutic Class
Anticancer Agents
Structure
3D MOL 2D MOL
Formula
C21H19ClN4O4
Canonical SMILES
COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
InChI
InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
InChIKey
WOSKHXYHFSIKNG-UHFFFAOYSA-N
CAS Number
CAS 204460-24-2
Pharmaceutical Properties Molecular Weight 426.9 Topological Polar Surface Area 116
Heavy Atom Count 30 Rotatable Bond Count 6
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
XLogP
2.8
PubChem CID
9823820
PubChem SID
123098996 ,123110209 ,124757043 ,125163847 ,125749042 ,126665901 ,131314303 ,131480711 ,134221774 ,135262444 ,135626656 ,135685148 ,135685149 ,135685168 ,136367339 ,136367958 ,137262627 ,137276042 ,139802275 ,144115929 ,14782907 ,152258284 ,152344144 ,160647123 ,162011787 ,162037768 ,162527769 ,164041901 ,174560999 ,178103998 ,180386840 ,198978519 ,202553041 ,223669921 ,223705252 ,223913134 ,227134592 ,24126764 ,242060265 ,247802696 ,251911433 ,251971223 ,252150297 ,252215326 ,252215327 ,252451828 ,252543308 ,44859775 ,74753053 ,99436922
ChEBI ID
ChEBI:85994
TTD Drug ID
D0R0FO
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Lenvatinib was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer. Sci Rep. 2019 Apr 1;9(1):5404.

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