Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00258
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| Drug Name |
Furosemide
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| Synonyms |
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid; 4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid; 4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid; 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid; 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid; 4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid; Aisemide; Aisemide (TN); Aldalix; Aldic; Aluzine; Anfuramaide; Apo-Frusemide; Apo-Furosemide; Apo-Furosemide (TN); Aquarid; Aquasin; Arasemide; Beronald; Beronald (TN); Bioretic; Cetasix; Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure; Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure [German]; Depix; Desal; Desdemin; Desdemin (TN); Dirine; Disal; Discoid; Discoid (TN); Disemide; Diumide-K; Diural; Diural (TN); Diurapid; Diurapid (TN); Diurin; Diurolasa; Diusemide; Diusil; Diuzol; Dranex; Dryptal; Dryptal (TN); Durafurid; Durafurid (TN); Edemid; Edenol; Eliur; Endural; Errolon; Errolon (TN); Eutensin; Eutensin (TN); F0182; F4381_SIGMA; FUN; FUROSEMIDE USP; Farsix; Fluidrol; Fluss; Franyl; Frudix (TN); Frumex; Frumide; Frusedan; Frusema; Frusemid; Frusemide; Frusemin; Frusenex; Frusetic; Frusetic (TN); Frusid; Frusid (TN); Fu sid; Fulsix; Fulsix (TN); Fuluvamide; Fuluvamide (TN); Fuluvamine; Fulvamide; Furanthril; Furanthryl; Furantral; Furantril; Furanturil; Furesis; Furesis (TN); Furetic; Furex; Furfan; Furix; Furix (TN); Furmid; Furo-Basan; Furo-Puren (TN); Furo-puren; Furobeta; Furocot; Furodiurol; Furodrix; Furomen; Furomex; Furomide M.D; Furomide M.D.; Furorese; Furosan; Furose; Furosedon; Furosedon (TN); Furosemid; Furosemida; Furosemida [INN-Spanish]; Furosemide (JP15/USP/INN); Furosemide (mita); Furosemide Monohydrochloride; Furosemide Monosodium Salt; Furosemide [USAN:INN:JAN]; Furosemidu; Furosemidu [Polish]; Furosemidum; Furosemidum [INN-Latin]; Furosemix; Furoside; Furosifar; Furosix; Furoter; Furovite; Fursemid; Fursemida; Fursemide; Fursol; Fusid; Fusid (TN); Golan; Hissuflux; Hoe-058A; Hydrex; Hydro; Hydro-rapid; Hydro-rapid(TN); Hydroled; Impugan; Impugan (TN); Jenafusid; Katlex; Katlex (TN); Kofuzon; Kolkin; Kutrix; LB 502; LB-502; Lasemid; Lasex; Lasiletten; Lasilix; Lasilix (TN); Lasix; Lasix (TN); Lasix Retard; Lasix Special; Lasix, Frusemide, Furosemide; Laxur; Lazix; Less Diur; Liside; Lodix (TN); Logirene; Lowpston; Lowpston (TN); Lowpstron; Luscek; Macasirool; Macasirool (TN); Marsemide; Mirfat; Mirfat (TN); Mita; Moilarorin;Myrosemide; Nadis; Nelsix; Neo-renal; Nicorol (TN); Novosemide; Odemase; Odemase (TN); Odemex; Oedemex; Oedemex (TN); Polysquall A; Prefemin; Profemin; Profemin (TN); Promedes; Promide; Protargen; Puresis; Radisemide; Radonna; Radouna; Retep; Rosemide; Rosemide (TN); Rosis; Rusyde; Rusyde (TN); Sal diureticum; Salinex; Salix; Salix (TN); Salix (brand of furosemide); Salurex; Salurid; Seguril; Selectofur; Sigasalur; Spirofur; Synephron; Transit; Trofurit; Trofurit (TN); Uremide; Uresix; Urex; Urex (TN); Urex-M; Urian; Uridon; Uritol; Urosemide; Vesix; Yidoli; Zafimida
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| Drug Type |
Small molecular drug
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| Indication | Edema associated with congestive heart failure [ICD11:BD10] | Approved | [1] | |||
| Therapeutic Class |
Diuretics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C12H11ClN2O5S
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| Canonical SMILES |
C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl
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| InChI |
InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
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| InChIKey |
ZZUFCTLCJUWOSV-UHFFFAOYSA-N
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| CAS Number |
CAS 54-31-9
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| Pharmaceutical Properties | Molecular Weight | 330.74 | Topological Polar Surface Area | 131 | ||
| Heavy Atom Count | 21 | Rotatable Bond Count | 5 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 7 | |||
| XLogP |
2
|
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| PubChem CID | ||||||
| PubChem SID |
10321703
,11112125
,11335750
,11360989
,11363994
,11366556
,11369118
,11371374
,11374398
,11377280
,11461961
,11466369
,11467489
,11484865
,11486058
,11488821
,11490253
,11492375
,11494914
,11531975
,11534249
,12014152
,140841
,14875224
,17389872
,22391430
,24277714
,26611753
,26680261
,26747275
,26747276
,26752834
,26752835
,29214787
,29222574
,46487913
,46506779
,47193739
,47216755
,47440227
,47515298
,47810733
,47885389
,48035085
,5651429
,597353
,7847397
,8149353
,8152188
,9229
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| ChEBI ID |
ChEBI:47426
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | OAT1 | Transporter Info | Organic anion transporter 1 | Substrate | [2] | |
| OAT3 | Transporter Info | Organic anion transporter 3 | Substrate | [2] | ||
| PEPT1 | Transporter Info | Peptide transporter 1 | Substrate | [3] | ||
| References | ||||||
| 1 | Furosemide was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9. | |||||
| 3 | Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. | |||||
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