Drug Information

General Information
Drug ID
DR00246
Drug Name
Ranolazine
Synonyms
(-)-Ranolazine; CVT-303; KEG-1295; Latixa; N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide; RAN D; RS-43285; RS-43285-003; Ran4; Ranexa; Ranexa (TN); Ranexa, Ranolazine; Ranolazine (USAN/INN); Ranolazine 2HCl; Ranolazine dihydrochloride
Drug Type
Small molecular drug
Indication Chronic angina [ICD11:BA40] Approved [1]
Therapeutic Class
Analgesics
Structure
3D MOL 2D MOL
Formula
C24H33N3O4
Canonical SMILES
CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
InChI
InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)
InChIKey
XKLMZUWKNUAPSZ-UHFFFAOYSA-N
CAS Number
CAS 142387-99-3
Pharmaceutical Properties Molecular Weight 427.5 Topological Polar Surface Area 74.3
Heavy Atom Count 31 Rotatable Bond Count 9
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
XLogP
2.7
PubChem CID
56959
PubChem SID
103482101 ,104171232 ,104253386 ,104311416 ,117573069 ,12013498 ,121363701 ,124750209 ,124757504 ,124799345 ,124881338 ,124881339 ,125164308 ,125360240 ,126583887 ,126622101 ,126630205 ,126656915 ,126666839 ,126724363 ,129701807 ,134338152 ,135015431 ,135684171 ,135692283 ,136375567 ,14856376 ,26612929 ,26749060 ,26749061 ,43114706 ,46505145 ,47207361 ,47795040 ,48169373 ,50070803 ,50107515 ,51004683 ,56463697 ,57313861 ,7980486 ,81040983 ,8184974 ,85171832 ,85789241 ,90340842 ,92124680 ,92307911 ,92309225 ,92712119
ChEBI ID
CHEBI:87690
TTD Drug ID
D03HYQ
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Ranolazine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Ranolazine-tacrolimus interaction. Ann Pharmacother. 2010 Nov;44(11):1844-9.

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