Drug Information

General Information
Drug ID
DR00230
Drug Name
Hydrocortisone
Synonyms
11-beta-Hydrocortisone; 11-beta-Hydroxycortisone; 11beta,17,21-Trihydroxyprogesterone; 11beta-Hydrocortisone; 11beta-Hydroxycortisone; 17-Hydroxycorticosterone; 17alpha-Hydroxycorticosterone; ACETASOL HC; ACETIC ACID W/ HYDROCORTISONE; Acticort; Acticort (TN); Aeroseb HC; Aeroseb-HC; Ala-Cort; Ala-Scalp; Alacort; Algicirtis; Alphaderm; Amberin; Anflam; Anti-inflammatory hormone; Anucort; Anucort-HC; Anusol HC (TN); AnusolHC; Aquacort; Aquanil HC; Balneol-hc; Barseb HC; Basan-Corti; Beta-hc; COR-OTICIN; CaldeCORT Spray; Cetacort; Chronocort; Clear aid; Cleiton; Cobadex; Colocort; Colocort (TN); Component of Lubricort; Component of Neo-Cort-Dome; Component of Otalgine; Corhydron; Cort-Dome; Cortanal; Cortef; Cortef (TN); Cortenema; Cortesal; Corticreme; Cortifair; Cortifan; Cortiment; Cortisol; Cortisol alcohol; Cortisol, Hydrocortisone; Cortisolonum; Cortisporin; Cortisporin Otico; Cortispray; Cortolotion; Cortonema; Cortoxide; Cortril; Cremesone; Cremicort-H; Cutisol; Cyclodextrin-encapsulated hydrocortisone; Delacort; Derm-Aid; Dermacort; Dermaspray; Dermil; Dermocortal; Dermolate; Dihydrocostisone; Dioderm; Dome-cort; Domolene-HC; Drotic; DuoCort; Ef corlin; Efcorbin; Efcortelan; Efcortelin; Eldecort; Eldercort; Epicort; Epicortisol; Epiderm H; Esiderm H; Evacort; Ficortril; Fiocortril; Flexicort; Foille Insetti; Genacort; Genacort (lotion); Glycort; Gyno-Cortisone; H 4001; H-Cort; HC #1; HC #4; HC (HYDROCORTISONE); HYDROCORTISONE AND ACETIC ACID; HYDROCORTISONE IN ABSORBASE; Heb Cort; Heb-Cort; Hi-cor; Hidalone; Hidro-Colisona; Hidrocortisona [INN-Spanish]; Hycort; Hycortol; Hycortole; Hydracort; Hydrasson; Hydro-Adreson; Hydro-Colisona; Hydro-RX; Hydrocortal; Hydrocorticosterone; Hydrocortisone (JP15/USP/INN); Hydrocortisone [INN:BAN:JAN]; Hydrocortisone alcohol; Hydrocortisone base; Hydrocortisone free alcohol; Hydrocortisone solution; Hydrocortisone-Water Soluble; Hydrocortisonum [INN-Latin]; Hydrocortisyl; Hydrocortone; Hydroskin; Hydroxycortisone; Hytisone; Hytone; Hytone (TN); Hytone lotion; Idrocortisone; Idrocortisone [DCIT]; Incortin-H; Incortin-hydrogen; Kendall's compound F; Komed HC; Kyypakkaus; Lacticare HC; Lacticare-HC; Lactisona; Lubricort; Maintasone; Medicort; Meusicort; Mildison; Milliderm; Neo-Cortef; Neosporin-H Ear; Nogenic HC; Nutracort; Nystaform-HC; ORLEX HC; Optef; Otocort; Otosone-F; Pediotic Suspension; Penecort; Permicort; Polcort H; Preparation H Hydrocortisone Cream; Prepcort; Prevex HC; Proctocort; Proctozone HC; Protocort; Rectasol-HC; Rectoid; Reichstein's substance M; Remederm HC; Sanatison; Scalp-Cort; Scalpicin Capilar; Schericur; Scheroson F; Sigmacort; Signef; Stie-cort; Stiefcorcil; Synacort; Systral Hydrocort; Tarcortin; Texacort; Texacort lotion 25; Timocort; Transderma H; Traumaide; Uniderm; VoSol HC; Vytone; Zenoxone; [3H]cortisol
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD11:9B72] Approved [1]
Therapeutic Class
Antiinflammatory Agents
Structure
3D MOL 2D MOL
Formula
C21H30O5
Canonical SMILES
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
InChI
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey
JYGXADMDTFJGBT-VWUMJDOOSA-N
CAS Number
CAS 50-23-7
Pharmaceutical Properties Molecular Weight 362.5 Topological Polar Surface Area 94.8
Heavy Atom Count 26 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
XLogP
1.6
PubChem CID
5754
PubChem SID
10321360 ,11404513 ,11466475 ,11467595 ,11486169 ,12013447 ,14828390 ,14852592 ,17405156 ,22391546 ,24278466 ,24715473 ,24895394 ,24895401 ,24895415 ,24895560 ,24895778 ,26737242 ,26738006 ,26751519 ,26751520 ,29224790 ,3154635 ,3998 ,4266384 ,46488041 ,46505089 ,47275088 ,47348953 ,47423772 ,47646134 ,47646135 ,48393456 ,48413873 ,49698498 ,49703922 ,49846290 ,49857418 ,53777700 ,53790729 ,53801089 ,53813055 ,75748 ,7847156 ,7979545 ,8138524 ,8144588 ,8153531 ,841765 ,855803
ChEBI ID
ChEBI:17650
TTD Drug ID
D0KR5B
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Hydrocortisone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302.

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