Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00222
|
|||||
| Drug Name |
Torsemide
|
|||||
| Synonyms |
1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea; 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea; 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea; 1-isopropyl-3-[(4-m-toluidino-3-pyridyl) sulfonyl]urea; AC 4464; BM 02015; BM-02015; Demadex; Demadex (TN); Demadex, Torsemide; Dilutol; GJ-1090; JDL 464; JDL-464; KS-1123; Luprac; Luprac (TN); N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide; N-(Isopropylcarbamoyl)-4-(m-tolylamino)pyridine-3-sulfonamide; N-{[(1-methylethyl)amino]carbonyl}-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide; PW-2132; Presoril; Sutril; TORSEMIDE; Toradiur; Torasemida; Torasemida [INN-Spanish]; Torasemide (JAN/INN); Torasemide N; Torasemidum; Torasemidum [INN-Latin]; Torem; Torocard; Torrem; Torsemide (USP); Torsemide [USAN]; Unat
|
|||||
| Drug Type |
Small molecular drug
|
|||||
| Indication | Edema associated with congestive heart failure [ICD11:BD10] | Approved | [1] | |||
| Therapeutic Class |
Diuretics
|
|||||
| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
C16H20N4O3S
|
|||||
| Canonical SMILES |
CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C
|
|||||
| InChI |
InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
|
|||||
| InChIKey |
NGBFQHCMQULJNZ-UHFFFAOYSA-N
|
|||||
| CAS Number |
CAS 56211-40-6
|
|||||
| Pharmaceutical Properties | Molecular Weight | 348.4 | Topological Polar Surface Area | 109 | ||
| Heavy Atom Count | 24 | Rotatable Bond Count | 5 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
2.7
|
|||||
| PubChem CID | ||||||
| PubChem SID |
11112793
,11364670
,11367232
,11369794
,11373102
,11373959
,11377957
,11467058
,11468178
,11484799
,11486816
,11488958
,11491647
,11492105
,11495590
,11528723
,12012656
,14900728
,25819958
,26612831
,26680347
,26719820
,26748988
,26748989
,34707389
,46386585
,46504760
,47291390
,47515595
,47515596
,47736767
,48259511
,48334790
,48416649
,49665992
,49666477
,49681707
,49699258
,49833537
,50107501
,53789088
,56313713
,57312605
,7585786
,7847448
,80124867
,81040892
,8177279
,85788916
,87560438
|
|||||
| ChEBI ID |
CHEBI:9637
|
|||||
| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | OATP1B1 | Transporter Info | Organic anion transporting polypeptide 1B1 | Substrate | [2] | |
| References | ||||||
| 1 | Torsemide was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Coleman J., Cox A. and Cowley N. (2011). Side Effects of Drugs Annual. Elsevier. | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.