Drug Information

General Information
Drug ID
DR00215
Drug Name
Dexamethasone
Synonyms
(3H)-Dexamethasone; 1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol; 16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone; 16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone; 16-alpha-Methyl-9-alpha-fluoroprednisolone; 16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol; 16.alpha.-Methyl-9.alpha.-fluoroprednisolone; 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol; 16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone; 16alpha-Methyl-9alpha-fluoroprednisolone; 9-alpha-Fluoro-16-alpha-methylprednisolone; 9.alpha.-Fluoro-16.alpha.-methylprednisolone; 9A-FLUORO-16BETA-METHYLPREDNISOLONE; 9alpha-Fluoro-16alpha-methylprednisolone; Adexone; Aeroseb-D; Aeroseb-Dex; Alcon Brand of Dexamethasone; Anaflogistico; Aphtasolon; Aphthasolone; Auxiron; Azium; Azium (Veterinary); Bisu DS; Calonat; Corson; Corsone; Cortisumman; DXM; Decacort; Decacortin; Decaderm; Decadron; Decadron (TN); Decadron Tablets, Elixir; Decadron, Dexamethasone; Decadron-LA; Decagel; Decaject; Decaject L.A.; Decaject-L.A.; Decalix; Decameth; Decasone; Decaspray; Dectancyl; Dekacort; Delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol; Delta1-9alpha-Fluoro-16alpha-methylcortisol; Deltafluorene; Dergramin; Deronil; Desadrene; Desametasone; Desametasone [DCIT]; Desamethasone; Desameton; Deseronil; Dex-ide; Dexa Mamallet; Dexa-Cortidelt;Dexa-Cortisyl; Dexa-Mamallet; Dexa-Scheroson; Dexa-sine; Dexacen-4; Dexacort; Dexacortal; Dexacortin; Dexadeltone; Dexafarma; Dexair; Dexalona; Dexaltin; Dexametasona; Dexametasona [INN-Spanish]; Dexameth; Dexamethansone; Dexamethasone (JP15/USP/INN); Dexamethasone Base; Dexamethasone Intensol; Dexamethasone [INN:BAN:JAN]; Dexamethasone alcohol; Dexamethasonum; Dexamethasonum [INN-Latin]; Dexamethazone; Dexamonozon; Dexapolcort; Dexaprol; Dexason; Dexasone; Dexinolon; Dexinoral; Dexone; Dexone 0.5; Dexone 0.75; Dexone 1.5; Dexone 4; Dexonium; Dexpak; Dextelan; Dezone; Dinormon; Dxms; ECR Brand of Dexamethasone; Fluormethylprednisolone; Fluormone; Fluorocort; Fortecortin; Foy Brand of Dexamethasone; Gammacorten; Hexadecadrol; Hexadrol; Hexadrol Elixir; Hexadrol Tablets; Hl-dex; ICN Brand of Dexamethasone; IontoDex; Isopto-Dex; Lokalison F; Loverine; Luxazone; MK 125; Maxidex; Mediamethasone; Merck Brand of Dexamethasone; Merz Brand 1 of Dexamethasone; Merz Brand 2 of Dexamethasone; Methylfluorprednisolone; Mexidex; Millicorten; Mymethasone; OTO-104; Ocu-trol;Pet-Derm Iii; Oradexon; Pet Derm III; Policort; Posurdex; Prednisolon F; Prednisolone F; Prodex; SK-Dexamethasone; Spoloven; Sunia Sol D; Superprednol; Turbinaire; Visumetazone
Drug Type
Small molecular drug
Indication Rheumatoid arthritis [ICD11:FA20] Approved [1]
Therapeutic Class
Antiinflammatory Agents
Structure
3D MOL 2D MOL
Formula
C22H29FO5
Canonical SMILES
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
InChI
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChIKey
UREBDLICKHMUKA-CXSFZGCWSA-N
CAS Number
CAS 50-02-2
Pharmaceutical Properties Molecular Weight 392.5 Topological Polar Surface Area 94.8
Heavy Atom Count 28 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
XLogP
1.9
PubChem CID
5743
PubChem SID
11404360 ,11407459 ,11538018 ,12012603 ,12159186 ,14805313 ,14805314 ,17389945 ,17396633 ,24715018 ,24858929 ,24869878 ,24893536 ,24893906 ,24894040 ,24894235 ,24894273 ,26512303 ,26697309 ,26752876 ,26752877 ,26752878 ,29224780 ,3139826 ,46508930 ,46518313 ,47869197 ,48168902 ,48317943 ,48413526 ,48415859 ,48421979 ,48425029 ,49833223 ,49857282 ,50105496 ,53788392 ,56310707 ,56310751 ,56310762 ,56310790 ,56310884 ,56310970 ,56311304 ,7847358 ,7886976 ,7979050 ,8153522 ,826237 ,92119
ChEBI ID
ChEBI:41879
TTD Drug ID
D0IT2G
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
PEPT1 Transporter Info Peptide transporter 1 Substrate [3]
Drug-Transporter Activity Data
Drug-Transporter Activity Data P-GP Transporter Info Km =826 microM Spodoptera frugiperda (Sf9) cells-MDR1 [2]
References
1 Dexamethasone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605.
3 Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.