Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00192
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| Drug Name |
L-homoarginine
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| Synonyms |
Homoarginine
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| Drug Type |
Small molecular drug
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| Indication | Acute ischemic stroke [ICD11:8B11] | preclinical | [1] | |||
| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C7H16N4O2
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| Canonical SMILES |
C(CCN=C(N)N)CC(C(=O)O)N
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| InChI |
InChI=1S/C7H16N4O2/c8-5(6(12)13)3-1-2-4-11-7(9)10/h5H,1-4,8H2,(H,12,13)(H4,9,10,11)/t5-/m0/s1
|
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| InChIKey |
QUOGESRFPZDMMT-YFKPBYRVSA-N
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| CAS Number |
CAS 9085
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| Pharmaceutical Properties | Molecular Weight | 188.23 | Topological Polar Surface Area | 128 | ||
| Heavy Atom Count | 13 | Rotatable Bond Count | 6 | |||
| Hydrogen Bond Donor Count | 4 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
-3.7
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| PubChem CID | ||||||
| PubChem SID |
103725626
,103826209
,104163949
,104319516
,111677876
,117541449
,118313738
,119503065
,126523470
,129077328
,132564670
,134974445
,135610090
,137477441
,144079913
,14769722
,152033900
,160789157
,160967042
,162181412
,162760459
,163387680
,164833490
,179316022
,184538601
,184611430
,186002908
,204370176
,204940000
,223535756
,223740029
,226427748
,249855606
,250134940
,250167553
,250198542
,252069777
,252225117
,252313808
,252350683
,252405157
,29227701
,49989438
,5030
,53776976
,57325418
,77308586
,93374632
,98561585
|
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| ChEBI ID |
ChEBI:27747
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | ORNT3 | Transporter Info | Mitochondrial ornithine transporter 3 | Substrate | [2] | |
| References | ||||||
| 1 | ClinicalTrials.gov (NCT03692234) Homoarginine Supplementation in Patients After Stroke | |||||
| 2 | The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84. | |||||
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