Drug Information

General Information
Drug ID
DR00191
Drug Name
Theophylline
Synonyms
1,3 Dimethylxanthine; 1,3-Dimethylxanthine; 1H-purine-2,6-dione; Accurbron; Acet-theocin; Aerobin; Aerolate; Aerolate III; Aerolate SR; Afonilm; Afonilum; Afonilum Retard; Aminophylline; Aquaphyllin; Armophylline; Asmalix; Asmax; Austyn; Bilordyl; Bronchodid Duracap; Bronchoparat; Bronchoretard; Bronkodyl; Bronkodyl SR; Bronkotabs; Cetraphylline; Choledyl SA; Chronophyllin; Constant T; Constant-T; ConstantT; Ct, theo von; Diffumal; Dimethylxanthine; Doraphyllin; Duraphyl; Duraphyllin; Egifilin; Elixex; Elixicon; Elixomin; Elixophyllin; Elixophyllin (TN); Elixophyllin SR; Elixophyllin(e); Elixophylline; Etheophyl; Euphylong; GS 2591A; Hylate; LASMA; LaBID; Labophylline; Lanophyllin; Liquophylline; Maphylline; Medaphyllin; Mudrane; Nuelin; Nuelin S.A; Nuelin S.A.; Nuelin SA; Optiphyllin; Parkophyllin; Physpan; Pro-vent; Pseudotheophylline; Pulmidur; Pulmo-Timelets; Quibron; Quibron T; Quibron T SR; Quibron T-SR; Quibron T/SR; Quibron TSR; Quibron-T; Quibron-T/SR; Quibron-t (TN); Respbid; Respicur; Respid; Slo Phyllin; Slo-bid; Slo-phyllin; SloPhyllin; Solosin; Somophyllin CRT; Somophyllin T; Somophyllin-CRT; Somophyllin-DF; Somophyllin-t; SomophyllinT; Spophyllin retard; Sustaire; Synophylate; T-Phyl; THEOBID JR; Talotren; Tefamin; Telb-DS; Telbans DrySyrup; Teocen 200; Teofilina; Teofilina [Polish]; Teofyllamin; Teolair; Teonova;Teosona; Tesona; Theacitin; Theal tablets; Theo 24; Theo Dur; Theo von ct; Theo-11; Theo-24; Theo-24 (TN); Theo-DS; Theo-Dur-Sprinkle; Theo-Nite; Theo-Organidin; Theo-Sav; Theo-dur; Theo24; Theobid; Theobid Duracap; Theobid Jr.; Theochron; Theocin; Theoclair-SR; Theoclear; Theoclear 80; Theoclear L.A.-130; Theoclear LA; Theoclear-200; Theoclear-80;Theodur G (TN); Theocontin; Theodel; Theodrip; Theodur; Theodur Dry Syrup; Theodur G; Theofol; Theograd; Theokin; Theolair; Theolair (TN); Theolair-SR; Theolix; Theolixir; Theona P; Theonite; Theopek; Theophyl; Theophyl-225; Theophyl-SR; Theophyline; Theophyllin; Theophylline (JP15); Theophylline-SR; Theophylline-[8-3H; Theoplus; Theospan; Theostat; Theostat 80; Theotard; Theovent; Uni-Dur; Unifyl; Unilong; Uniphyl; Uniphyl (TN); Uniphyllin; Uniphyllin continus; Uniphylline; Von ct, theo; X 115; Xanthium; Xantivent
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD11:CA22] Approved [1]
Therapeutic Class
Bronchodilator Agents
Structure
3D MOL 2D MOL
Formula
C7H8N4O2
Canonical SMILES
CN1C2=C(C(=O)N(C1=O)C)NC=N2
InChI
InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
InChIKey
ZFXYFBGIUFBOJW-UHFFFAOYSA-N
CAS Number
CAS 58-55-9
Pharmaceutical Properties Molecular Weight 180.16 Topological Polar Surface Area 69.3
Heavy Atom Count 13 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
XLogP
0
PubChem CID
2153
PubChem SID
10518342 ,10528330 ,10528902 ,11335378 ,11360617 ,11363932 ,11366494 ,11369056 ,11371683 ,11373924 ,11377218 ,11406129 ,11461589 ,11466848 ,11466901 ,11467968 ,11468021 ,11484559 ,11486376 ,11486602 ,11488658 ,11490488 ,11492168 ,11494852 ,11537637 ,14772732 ,17389715 ,21317898 ,22390364 ,22391535 ,24277677 ,24900236 ,24900474 ,24900581 ,26611941 ,26679415 ,3140219 ,4657313 ,5643002 ,603445 ,68760 ,7847437 ,7890742 ,7980771 ,8026207 ,8144385 ,8149549 ,8151463 ,855679 ,9340
ChEBI ID
ChEBI:28177
TTD Drug ID
D0F8RA
DT(s) Transporting This Drug OAT2 Transporter Info Organic anion transporter 2 Substrate [2]
Drug-Transporter Activity Data
Drug-Transporter Activity Data OAT2 Transporter Info Km =12.6 microM Oocytes-OAT2 [2]
References
1 Theophylline was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22.

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