Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00183
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| Drug Name |
Tacrine
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| Synonyms |
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8); 1,2,3,4-Tetrahydro-9-acridineamine; 1,2,3,4-Tetrahydro-acridin-9-ylamine; 1,2,3,4-Tetrahydroaminoacridine; 1,2,3,4-tetrahydroacridin-9-amine; 5-Amino-6,7,8,9-tetrahydroacridine (European); 9-AMINOTETRAHYDROACRIDINE; 9-Acridinamine, 1,2,3,4-tetrahydro-(9CI); 9-Amino-1,2,3,4-Tetrahydroacridine Hydrate Hydrochloride Hydrate; 9-amino-1,2,3,4-tetrahydroacridine; BBL001044; CS 12602; Cognex; Cognex (TN); Romotal; Tacrina; Tacrina [INN-Spanish]; Tacrinal; Tacrinal (TN); Tacrine (INN); Tacrine [INN:BAN]; Tacrine hydrochloride; Tacrinum; Tacrinum [INN-Latin]; Tenakrin; Tetrahydroaminacrine; Tetrahydroaminoacridine; Tetrahydroaminocrin; Tetrahydroaminocrine; Tha
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD11:8A20] | Approved | [1] | |||
| Therapeutic Class |
Parasympathomimetics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C13H14N2
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| Canonical SMILES |
C1CCC2=NC3=CC=CC=C3C(=C2C1)N
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| InChI |
InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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| InChIKey |
YLJREFDVOIBQDA-UHFFFAOYSA-N
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| CAS Number |
CAS 321-64-2
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| Pharmaceutical Properties | Molecular Weight | 198.26 | Topological Polar Surface Area | 38.9 | ||
| Heavy Atom Count | 15 | Rotatable Bond Count | 0 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 2 | |||
| XLogP |
2.7
|
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| PubChem CID | ||||||
| PubChem SID |
10518487
,10589113
,11110734
,11113824
,11336111
,11361350
,11363310
,11365872
,11368434
,11372617
,11374476
,11376596
,11451154
,11462322
,11466357
,11467477
,11485559
,11485994
,11489628
,11491524
,11492634
,11494230
,15120928
,24339135
,26697094
,26746578
,26751997
,26751998
,29221124
,3249865
,4630
,46392558
,46393827
,46393828
,46505487
,46509736
,47291206
,47365271
,47440346
,47440347
,47515380
,47515381
,47589065
,47736566
,47736567
,597209
,7423820
,7890757
,7980766
,8151345
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| ChEBI ID |
ChEBI:45980
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Tacrine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes. J Pharm Pharm Sci. 2014;17(3):427-38. | |||||
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