Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00159
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| Drug Name |
Paliperidone
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| Synonyms |
Invega Sustenna; JNS-010; Paliperidone (depot injection, NanoCrystal); Paliperidone (depot injection, NanoCrystal), Johnson & Johnson; Paliperidone (injectable, NanoCrystal), Elan; Paliperidone palmitate; Xeplion
|
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| Drug Type |
Small molecular drug
|
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| Indication | Schizophrenia [ICD11:6A20] | Approved | [1] | |||
| Structure |
|
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| 3D MOL | 2D MOL | |||||
| Formula |
C23H27FN4O3
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| Canonical SMILES |
CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
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| InChI |
InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3
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| InChIKey |
PMXMIIMHBWHSKN-UHFFFAOYSA-N
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| CAS Number |
CAS 199739-10-1
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| Pharmaceutical Properties | Molecular Weight | 426.5 | Topological Polar Surface Area | 82.2 | ||
| Heavy Atom Count | 31 | Rotatable Bond Count | 4 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 7 | |||
| XLogP |
2.2
|
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| PubChem CID | ||||||
| PubChem SID |
10236700
,103604037
,103910909
,104105311
,104397925
,118046559
,121361150
,125307525
,125341102
,126584511
,126621140
,126649064
,126650388
,126667060
,128939139
,131465791
,131549340
,134338126
,135072932
,136367845
,137166111
,142528484
,144116334
,14905143
,152258953
,152344196
,160647798
,160810375
,160964597
,162185890
,163088563
,163371020
,163564516
,163981461
,164175255
,164785605
,170501956
,171063034
,22395187
,29296762
,46506296
,47207025
,50035150
,51002222
,57339070
,85229944
,85246150
,90341688
,92719038
,92729808
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| ChEBI ID |
CHEBI:83804
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Paliperidone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Invega (paliperidone) extended release tablets FDA Label | |||||
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