Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00158
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| Drug Name |
Glimepiride
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| Synonyms |
1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea; 3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide; 3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro; 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide; 64598P; Amarel; Amaryl; Amaryl (TN); Amaryl, Glista OD, Glimepiride; Endial; Glimepirid; Glimepirida; Glimepirida [Spanish]; Glimepiride (JAN/USP/INN); Glimepiride [USAN:BAN:INN]; Glimepiridum; Glimepiridum [Latin]; Glimepride; Glimer; Glymepirid; HOE 490; Hoe-490; Novo-glimepiride; PMS-glimepiride; Ratio-glimepiride; Roname; Sandoz glimepiride; Solosa
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| Drug Type |
Small molecular drug
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| Indication | Diabetes [ICD11:5A10-5A14] | Approved | [1] | |||
| Therapeutic Class |
Hypoglycemic Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C24H34N4O5S
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| Canonical SMILES |
CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
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| InChI |
InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)
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| InChIKey |
WIGIZIANZCJQQY-UHFFFAOYSA-N
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| CAS Number |
CAS 93479-97-1
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| Pharmaceutical Properties | Molecular Weight | 490.6 | Topological Polar Surface Area | 133 | ||
| Heavy Atom Count | 34 | Rotatable Bond Count | 7 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 5 | |||
| XLogP |
3.9
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| PubChem CID | ||||||
| PubChem SID |
103394534
,103543151
,103913636
,104171333
,104303626
,11112876
,11466679
,11467799
,11486338
,12013623
,14908413
,24895093
,26719876
,26755029
,26755030
,29222609
,32963623
,46386690
,46508842
,47589079
,47959862
,48155569
,48185080
,48334594
,49648856
,49699123
,49731995
,49835734
,50037704
,50126308
,5043708
,56313637
,57321825
,77374551
,7847659
,7979409
,81040871
,81092812
,8145852
,8152210
,85787655
,85787837
,91613422
,92125647
,92308643
,92309214
,92711714
,9871
,99344865
,99437102
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| ChEBI ID |
ChEBI:5383
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | BSEP | Transporter Info | Bile salt export pump | Substrate | [2] | |
| References | ||||||
| 1 | Glimepiride was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43. | |||||
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