Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00141
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| Drug Name |
Methadone
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| Synonyms |
(+)-Methadone; (+-)-Methadone; (+/-)-Methadone; (+/-)-Tussal; (-)-(R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; (-)-Methadone; (6R)-Methadone; (R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; (R)-6-(Dimethylamino)-4,4-diphenyl-3-hetpanone; (S)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; 3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-(9CI); 6-(Dimethylamino)-4,4-diphenyl-3-heptanone dl-mixture; 6-(dimethylamino)-4,4-diphenylheptan-3-one; 6-Dimethylamino-4,4-diphenyl-3-heptanone; 6-dimethylamino-4,4-di(phenyl)heptan-3-one; 6S-Methadone; A 4624; AN 148; AN-148 (*Hydrochloride*); Adanon; Algovetin; Althose; Amidon; Amidone; Amidone (TN); Biscuits; D-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; D-Methadone; Dextromethadone; Diaminon; Dl-Methadone; Dollies; Dolly; Dolophin; Dolophine; Dolophine (*Hydrochloride*); Dolophine (TN); Fenadone (*Hydrochloride*); Heptadon (TN); Heptadone; Heptadone (*Hydrochloride*); Heptanon; Heptanon (*Hydrochloride*); Heptanon (pharmaceutical); Hoechst 10820; Hoescht 10820 (*Hydrochloride*); K 174; Ketalgin; L-(+)-Methadone; L-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; L-Methadone; L-Polamidon; L-Polamivet; Levometadona; Levometadona [INN-Spanish]; Levomethadone [INN]; Levomethadonum; Levomethadonum [INN-Latin]; Levothyl; Metadona; Metadona [INN-Spanish]; Metadona [Spanish]; Metadone; Metadone [DCIT]; Metasedin; Methadon; Methadona; Methadona [Spanish]; Methadone (BAN); Methadone HCL Intensol; Methadone M; Methadone [INN:BAN]; Methadonum; Methadonum [INN-Latin]; Methadonum [Latin]; Methadose (TN); Methaquaione; Phenadone; Phenadone (*Hydrochloride*); Physeptone (TN); Polamidone; Polamivet; Racemic methadone; S-(+)-Methadone; Sedo-Rapide; Symoron (TN); Tussol; Westadone;Dolophine HCL
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD11:MG30-MG7Z] | Approved | [1] | |||
| Opioid type drug dependence [ICD11:6C43] | Approved | [1] | ||||
| Therapeutic Class |
Analgesics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C21H27NO
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| Canonical SMILES |
CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
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| InChI |
InChI=1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3/t17-/m1/s1
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| InChIKey |
USSIQXCVUWKGNF-QGZVFWFLSA-N
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| CAS Number |
CAS 76-99-3
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| Pharmaceutical Properties | Molecular Weight | 309.4 | Topological Polar Surface Area | 20.3 | ||
| Heavy Atom Count | 23 | Rotatable Bond Count | 7 | |||
| Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 2 | |||
| XLogP |
3.9
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| PubChem CID | ||||||
| PubChem SID | ||||||
| ChEBI ID |
ChEBI:6807
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Methadone was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites. Pharmacology. 2007;80(4):304-11. | |||||
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