Drug Information

General Information
Drug ID
DR00115
Drug Name
Lysine
Synonyms
Enisyl
Drug Type
Small molecular drug
Indication Schizophrenia [ICD11:6A20] preclinical [1]
Structure
3D MOL 2D MOL
Formula
C6H14N2O2
Canonical SMILES
C(CCN)CC(C(=O)O)N
InChI
InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1
InChIKey
KDXKERNSBIXSRK-YFKPBYRVSA-N
CAS Number
CAS 56-87-1
Pharmaceutical Properties Molecular Weight 146.19 Topological Polar Surface Area 89.3
Heavy Atom Count 10 Rotatable Bond Count 5
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
XLogP
-3
PubChem CID
5962
PubChem SID
10527684 ,14719441 ,15219170 ,15321566 ,17486473 ,22435038 ,24896404 ,24896515 ,24901905 ,26708216 ,29224985 ,3152007 ,3349 ,46392835 ,46393686 ,46504770 ,46506741 ,48416191 ,49854144 ,49989434 ,53776958 ,53776966 ,53776972 ,53776985 ,53776989 ,53776992 ,53776997 ,56260873 ,56269965 ,57304237 ,57304479 ,57323083 ,57580879 ,57651911 ,6436589 ,77923504 ,7849363 ,81044533 ,81055044 ,81065730 ,8144553 ,8153705 ,819792 ,824263 ,824970 ,829089 ,836276 ,837782 ,837797 ,837799
ChEBI ID
ChEBI:18019
TTD Drug ID
D07TMZ
DT(s) Transporting This Drug ORNT3 Transporter Info Mitochondrial ornithine transporter 3 Substrate [2]
Drug-Transporter Activity Data
Drug-Transporter Activity Data ORNT3 Transporter Info Km =710 microM SLC25A29-reconstituted Liposomes [2]
References
1 ClinicalTrials.gov (NCT00996242) An Exploratory Open Label Study of Adjunctive L-lysine Treatment in Patients With Schizophrenia
2 The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84.

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