Drug Information

General Information
Drug ID
DR00103
Drug Name
Ethinyl estradiol
Synonyms
17 alpha-Ethinylestradiol; 17 alpha-Ethynylestradiol; 17 alpha-Ethynyloestradiol; 17 alpha-ethinyestradiol; 17-Ethinyl-3,17-estradiol; 17-Ethinyl-3,17-oestradiol; 17-Ethinylestradiol; 17-Ethynylestradiol; 17-Ethynyloestradiol; 17-alpha-Ethinyl-17-beta-estradiol; 17-alpha-Ethynyl-17-beta-oestradiol; 17-alpha-Ethynylestradiol; 17-alpha-Ethynylestradiol-17-beta; 17-alpha-Ethynylestradiol-l7-beta; 17-alpha-Ethynyloestradiol-17-beta; 17-alpha-ethynyl estradiol; 17.alpha.-Ethinyl-17.beta.-estradiol; 17.alpha.-Ethinylestradiol; 17.alpha.-Ethynyl-17.beta.-oestradiol; 17.alpha.-Ethynylestradiol; 17.alpha.-Ethynyloestradiol; 17a-Ethynylestradiol; 17alpha-Ethinyl estradiol; 17alpha-Ethinylestradiol; 17alpha-Ethinylestradiol-17beta; 17alpha-Ethynylestradiol; 17alpha-Ethynyloestradiol; 17alpha-Ethynyloestradiol-17beta; Aethinyloestradiolum; Aethinyoestradiol; Aethinyoestradiol [German]; Amenoron; Amenorone; Anovlar; Certostat; Chee-O-Gen; Chee-O-Genf; Component of Demulen; Component of Oracon; Component of Ortrel; Cyclosa; Dicromil; Diognat-E; Diogyn E; Diogyn-E; Diprol; Dyloform; EE(sub 2); EE2; ETHINYLESTRADIOL; Effik Brand of Ethinyl Estradiol; Ertonyl; Esteed; Estigyn; Estinyl; Estinyl (TN); Eston-E; Estopherol; Estoral; Estoral (Orion); Estoral (VAN);Estradiol, Ethinyl; Estoral [Orion]; Estorals; Estradiol, Ethynyl; Ethidol; Ethinoral; Ethinyl E2; Ethinyl Estradiol Hemihydrate; Ethinyl Estradiol [USP]; Ethinyl Estradiol, (8 alpha)-Isomer; Ethinyl Oestradiol Effik; Ethinyl estradiol (USP); Ethinyl-Oestradiol Effik; Ethinyl-oestranol; Ethinylestradiol (JP15/INN); Ethinylestradiol Jenapharm; Ethinylestradiol [INN:BAN:JAN]; Ethinylestradiolum; Ethinylestradiolum [INN-Latin]; Ethinylestriol; Ethinyloestradiol; Ethinyloestradiol [Steroidal oestrogens]; Ethy 11; Ethynyl estradiol; Ethynylestradiol; Ethynylestradiol, Ethinyl Estradiol; Ethynyloestradiol; Eticyclin; Eticyclol; Eticylol; Etinestrol; Etinestryl; Etinilestradiol; Etinilestradiol [INN-Spanish]; Etinilestradiolo; Etinilestradiolo [DCIT]; Etinoestryl; Etistradiol; Etivex; Feminone; Follicoral; Ginestrene; Hemihydrate, Ethinyl Estradiol; Inestra; Jenapharm Brand of Ethinyl Estradiol; Jenapharm, Ethinylestradiol; Kolpolyn; Linoral; Lynoral;Menolyn; Microfollin; Microfollin Forte; Neo-Estrone; Nogest-S; Novestrol; OVULEN-21; OVULEN-28; Oradiol; Orestralyn; Orestrayln; Organon Brand of Ethinyl Estradiol; Ortho-Cyclen; PUBERTAL ETHINYL ESTRADIOL STUDY; Palonyl; Perovex; Primogyn; Primogyn C; Primogyn M; Progynon C; Progynon M; Prosexol; Schering Brand of Ethinyl Estradiol; Spanestrin; Ylestrol
Drug Type
Small molecular drug
Indication Female hypogonadism [ICD11:5A61.0] Approved [1]
Therapeutic Class
Estrogens
Structure
3D MOL 2D MOL
Formula
C20H24O2
Canonical SMILES
CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O
InChI
InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
InChIKey
BFPYWIDHMRZLRN-SLHNCBLASA-N
CAS Number
CAS 57-63-6
Pharmaceutical Properties Molecular Weight 296.4 Topological Polar Surface Area 40.5
Heavy Atom Count 22 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
XLogP
3.7
PubChem CID
5991
PubChem SID
11404629 ,11533305 ,14898199 ,14922735 ,17389896 ,24702258 ,24714981 ,24869989 ,24894585 ,26512288 ,26719638 ,26753042 ,29215113 ,29225006 ,46386858 ,46508618 ,48413731 ,48415973 ,48421874 ,48423390 ,48425117 ,49854450 ,53788253 ,56311124 ,56311183 ,56311332 ,56311399 ,56311403 ,56311406 ,56311535 ,56312680 ,56313453 ,56313621 ,56313838 ,56313881 ,56314241 ,57288591 ,57650750 ,71821446 ,76025 ,78032044 ,7847620 ,7979198 ,81093168 ,8139942 ,8153725 ,92308409 ,92713395 ,93165614 ,9737
ChEBI ID
ChEBI:4903
TTD Drug ID
D06NXY
DT(s) Transporting This Drug P-GP Transporter Info P-glycoprotein 1 Substrate [2]
References
1 Ethinyl estradiol was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93.

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