Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00055
|
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| Drug Name |
Codeine
|
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| Synonyms |
(-)-Codeine; 76-57-3; CCRIS 7555; CHEBI:16714; CODEINE BASE; Codein; Codeine Anhydrate; Codeine anhydrous; Codeine polistirex; Codicept; Coducept; EINECS 200-969-1; HSDB 3043; Methylmorphine; Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-; Morphine 3-methyl ether; Morphine monomethyl ether; Morphine-3-methyl ester; Morphine-3-methyl ether; Norcodeine, N-methyl; Norcodine, N-methyl; O(3)-methylmorphine; O3-Methylmorphine; UNII-UX6OWY2V7J; UX6OWY2V7J; codeina; codeinum; l-Codeine
|
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| Drug Type |
Small molecular drug
|
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| Indication | Pain [ICD11:MG30-MG7Z] | Approved | [1] | |||
| Therapeutic Class |
Analgesics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C18H21NO3
|
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| Canonical SMILES |
CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O
|
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| InChI |
InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1
|
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| InChIKey |
OROGSEYTTFOCAN-DNJOTXNNSA-N
|
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| CAS Number |
CAS 76-57-3
|
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| Pharmaceutical Properties | Molecular Weight | 299.4 | Topological Polar Surface Area | 41.9 | ||
| Heavy Atom Count | 22 | Rotatable Bond Count | 1 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
1.1
|
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| PubChem CID | ||||||
| PubChem SID |
103169342
,103930322
,104000895
,11039235
,117497011
,124954734
,126631803
,126678046
,128851630
,134337528
,134971680
,135650117
,137001257
,137175320
,142842434
,144207280
,14825207
,152094958
,15419416
,160963666
,164838528
,175268396
,175442317
,179151116
,223554832
,223680835
,223739746
,226395484
,241129665
,24892429
,24892819
,28325869
,39317728
,46507764
,48413480
,48415816
,48423163
,49855816
,50881119
,53788605
,57653987
,57654027
,7978983
,8144934
,841961
,8425
,87544102
,92710514
|
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| ChEBI ID |
ChEBI:16714
|
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | 1-Oct | Transporter Info | Organic cation transporter 1 | Substrate | [2] | |
| References | ||||||
| 1 | Codeine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. Diabetes. 2015 May;64(5):1786-93. | |||||
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