Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00047
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| Drug Name |
D-serine
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| Synonyms |
(2R)-2-amino-3-hydroxy-propanoic acid; (2R)-2-amino-3-hydroxypropanoic acid; (2R)-serine; (R)-2-Amino-3-hydroxypropionic acid; (R)-2-amino-3-hydroxypropanoic acid; (R)-Serine; 1K77H2Z9B1; AI3-18476; CHEBI:16523; CHEMBL285123; D-2-Amino-3-hydroxypropanoic acid; D-2-Amino-3-hydroxypropionic Acid; D-Ser; D-Serin; D-Serine, 98%; DSN; EINECS 206-229-4; MFCD00004269; MTCFGRXMJLQNBG-UWTATZPHSA-N; NCGC00094363-03; NSC 77689; NSC77689; Serine D-form; Serine, D-; UNII-1K77H2Z9B1; [3h]-d-serine; d-(+)-serine; serine d-
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| Drug Type |
Small molecular drug
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| Indication | Serine deficiency disorder [ICD11:5C50.6] | Phase 4 | [1] | |||
| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C3H7NO3
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| Canonical SMILES |
C(C(C(=O)O)N)O
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| InChI |
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
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| InChIKey |
MTCFGRXMJLQNBG-UWTATZPHSA-N
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| CAS Number |
CAS 312-84-5
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| Pharmaceutical Properties | Molecular Weight | 105.09 | Topological Polar Surface Area | 83.6 | ||
| Heavy Atom Count | 7 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
-3.1
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| PubChem CID | ||||||
| PubChem SID |
103060962
,103204181
,103822437
,104038215
,104349603
,117518385
,14747454
,15146420
,17405644
,24278008
,26718244
,26753645
,26753646
,4003
,43127470
,46392862
,46508200
,47811035
,47885661
,48110736
,49748509
,49846980
,50045910
,50096464
,50096469
,50106988
,50106989
,53778194
,56312452
,56313140
,56437651
,57318000
,588250
,626975
,7887195
,80530258
,8143525
,8194408
,829388
,839068
,85756772
,87350321
,87575662
,87636300
,90341480
,92298581
,92303181
,92717308
,99213597
,99224311
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| ChEBI ID |
ChEBI:16523
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | ASCT1 | Transporter Info | Alanine/serine/cysteine/threonine transporter 1 | Substrate | [2] | |
| ASCT2 | Transporter Info | Alanine/serine/cysteine/threonine transporter 2 | Substrate | [2] | ||
| Drug-Transporter Activity Data | ||||||
| Drug-Transporter Activity Data | ASCT1 | Transporter Info | Km =206 microM | Oocytes-ASCT1 | [2] | |
| ASCT1 | Transporter Info | Km =2200 microM | Rat hippocampal astrocyte-ASCT1 | [2] | ||
| ASCT2 | Transporter Info | Km =167 microM | Oocytes-ASCT2 | [2] | ||
| References | ||||||
| 1 | ClinicalTrials.gov (NCT01018056) Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission | |||||
| 2 | D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551. | |||||
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