Drug Information

General Information
Drug ID
DR00023
Drug Name
Memantine
Synonyms
Memantine (extended release); Memantine (extended release), Forest; Memantine ER; Namenda XR
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD11:8A20] Approved [1]
Structure
3D MOL 2D MOL
Formula
C12H21N
Canonical SMILES
CC12CC3CC(C1)(CC(C3)(C2)N)C
InChI
InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
InChIKey
BUGYDGFZZOZRHP-UHFFFAOYSA-N
CAS Number
CAS 19982-08-2
Pharmaceutical Properties Molecular Weight 179.3 Topological Polar Surface Area 26
Heavy Atom Count 13 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
XLogP
3.3
PubChem CID
4054
PubChem SID
103211988 ,11167042 ,11335243 ,11360482 ,11363501 ,11366063 ,11368625 ,11372025 ,11374681 ,11376787 ,11461454 ,11467006 ,11468126 ,11485192 ,11486662 ,11489224 ,11490738 ,11492836 ,11494421 ,15147301 ,24310548 ,26751885 ,29223165 ,3221249 ,46506702 ,47290972 ,47290973 ,47440080 ,47515155 ,47662108 ,47736297 ,47736298 ,48184834 ,48259056 ,48334316 ,49698917 ,50057972 ,50104569 ,53790630 ,57322117 ,586325 ,598200 ,6380039 ,74530305 ,7737264 ,8149719 ,8152542 ,90341818 ,96024864 ,99301156
ChEBI ID
ChEBI:64312
TTD Drug ID
D01JEU
DT(s) Transporting This Drug 2-Oct Transporter Info Organic cation transporter 2 Substrate [2]
Drug-Transporter Activity Data
Drug-Transporter Activity Data 2-Oct Transporter Info Km =34 microM Human embryonic kidney cells (HEK293)-OCT2 [2]
2-Oct Transporter Info Km =34 microM Oocytes-OCT2 [2]
References
1 Memantine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52.

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