Drug Information

General Information
Drug ID
DR00715
Drug Name
Sulindac
Synonyms
(E)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-[[4-(methyl-sulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid; 2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid; Aclin; Aflodac; Alphapharm Brand of Sulindac; Apo Sulin; Apo-Sulin; Apotex Brand of Sulindac; Arthrobid; Arthrocine; Cahill May Roberts Brand of Sulindac; Chemia Brand of Sulindac; Chibret; Cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; Cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid; Clinoril; Clinoril (TN); Copal; Copal resin; Copal rosin varnish; Copals; Gum copal; Kenalin; KendrickBrand of Sulindac; Klinoril; MK 231; MK-231; MK231; Merck Brand of Sulindac; Merck Sharp & Dohme Brand of Sulindac; Mobilin; Novo Sundac; Novo-Sundac; Novopharm Brand of Sulindac; Nu Pharm Brand of Sulindac; Nu Sulindac; Nu-Pharm Brand of Sulindac; Nu-Sulindac; Resin copal; S 8139; Sulindac (JAN/USP/INN); Sulindac [USAN:BAN:INN:JAN]; Sulindac sulfoxide; Sulindaco; Sulindaco [INN-Spanish]; Sulindacum; Sulindacum [INN-Latin]; Sulindal; Z-5-Fluoro-2-methyl-1-[p-(methlsulfinyl)benzylidene]indene-3-acetic acid; [(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfinyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid; {(1E)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid; {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid; {5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1h-inden-3-yl}acetic acid
Drug Type
Small molecular drug
Indication Rheumatoid arthritis [ICD11:FA20] Approved [1]
Therapeutic Class
Antiinflammatory Agents
Structure
3D MOL 2D MOL
Formula
C20H17FO3S
Canonical SMILES
CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O
InChI
InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChIKey
MLKXDPUZXIRXEP-MFOYZWKCSA-N
CAS Number
CAS 38194-50-2
Pharmaceutical Properties Molecular Weight 356.4 Topological Polar Surface Area 73.6
Heavy Atom Count 25 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
XLogP
3.4
PubChem CID
1548887
PubChem SID
103179013 ,103925149 ,104170038 ,104253449 ,110524953 ,11111823 ,11111824 ,11114189 ,11534177 ,118307514 ,121361866 ,121362536 ,14828051 ,17405626 ,26611935 ,26680385 ,26732639 ,26747172 ,26747173 ,32248851 ,46506570 ,4693 ,47216762 ,47736459 ,47959726 ,47959727 ,47959728 ,48035101 ,48035102 ,48259216 ,49699049 ,49982642 ,50106970 ,50106971 ,53778176 ,53789046 ,57409048 ,75972879 ,7847188 ,7980709 ,8149543 ,85231236 ,85787894 ,8653294 ,90341400 ,91011398 ,92124295 ,92303413 ,92307725 ,99301689
ChEBI ID
ChEBI:9352
TTD Drug ID
D0Z5IU
DT(s) Transporting This Drug MRP4 Transporter Info Multidrug resistance-associated protein 4 Substrate [2]
References
1 Sulindac was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus. J Neurochem. 2010 Oct;115(1):200-8.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.