Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00595
|
|||||
| Drug Name |
Chlorpheniramine
|
|||||
| Synonyms |
1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine; 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine; 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine; 4-Chloropheniramine; Aller-Chlor; Allergican; Allergisan; Antagonate; CHLORPHENIRAMINE (SEE ALSO: CHLORPHENIRAMINE MALEATE (CAS113-92-8)); Chlo-amine; Chlor-Pro; Chlor-Trimeton (TN); Chlor-Trimeton Repetabs; Chlor-Tripolon (TN); Chlor-trimeton; Chloropheniramine; Chlorophenylpyridamin; Chlorophenylpyridamine; Chloropiril; Chloroprophenpyridamine; Chlorphenamine; Chlorphenamine (INN); Chlorphenamine [INN]; Chlorphenaminum; Chlorphenaminum [INN-Latin]; Chlorpheniraminum; Chlorprophenpyridamine; Clofeniramina; Clofeniramina (TN); Clorfenamina; Clorfenamina [INN-Spanish]; Clorfeniramina; Clorfeniramina [Italian]; Cloropiril; Comakin (TN); Gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine; Gamma-(4-Chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine; Gen-Allerate; Haynon; Hayon; Histadur; ISOCLOR; Kloromin; Novo-Pheniram; Pediacare Allergy Formula; Phenetron; PiriIton; Piriton; Piriton (TN); Polaronil; Telachlor; Teldrin; [3H]Chlorpheniramine
|
|||||
| Drug Type |
Small molecular drug
|
|||||
| Indication | Allergic rhinitis [ICD11:CA08.0] | Approved | [1] | |||
| Urticaria [ICD11:EB00-EB0Y] | Approved | [1] | ||||
| Therapeutic Class |
Antiallergic Agents
|
|||||
| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
C16H19ClN2
|
|||||
| Canonical SMILES |
CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
|
|||||
| InChI |
InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m1/s1
|
|||||
| InChIKey |
SOYKEARSMXGVTM-OAHLLOKOSA-N
|
|||||
| CAS Number |
CAS 132-22-9
|
|||||
| Pharmaceutical Properties | Molecular Weight | 274.79 | Topological Polar Surface Area | 16.1 | ||
| Heavy Atom Count | 19 | Rotatable Bond Count | 5 | |||
| Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 2 | |||
| XLogP |
3.4
|
|||||
| PubChem CID | ||||||
| PubChem SID |
109896795
,11110931
,11110932
,11112256
,11363014
,11365576
,11368138
,11371329
,11373943
,11376300
,11484028
,11487972
,11490161
,11492097
,11493954
,135650086
,135774423
,137002507
,15442268
,160666558
,174007153
,175269603
,179039539
,226396260
,33774101
,47719847
,48018097
,50064683
,50100400
,50225325
,57304992
,85789162
,9299815
|
|||||
| ChEBI ID |
ChEBI:52010
|
|||||
| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | MRP1 | Transporter Info | Multidrug resistance-associated protein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Chlorpheniramine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. J Pharm Sci. 2005 Mar;94(3):613-24. | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.