Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00517
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| Drug Name |
Ofloxacin
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| Synonyms |
(+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaz inyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; (+/-)-Floxin; (-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazin-6-carbonsaeure; 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; Bactocin; DEXTROFLOXACINE; DL 8280; DL-8280; DL-8280, HOE-280, Exocin, Flobacin, Floxin, Floxil, Monoflocet, Ofloxacin; Danoflox; Effexin; Exocin; Exocine; FLOXIN IN DEXTROSE 5%; FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER; Flobacin; Flodemex; Flotavid; Flovid; Floxal; Floxil; Floxin; Floxin (TN); Floxin Otic (TN); Floxin otic; Floxstat; Fugacin; HOE 280; HOE-280;Hoe-280; Inoflox; Kinflocin; Kinoxacin; Liflox; Loxinter; Marfloxacin; Marfloxacin (TN); Medofloxine; Mergexin; Novecin; Nufafloqo; O 8757; O-Flox; OFLX; OFX; ORF 18489; ORF-28489; Obide; Occidal; Ocuflox; Ocuflox (TN); Ofcin; Oflin; Oflocee; Oflocet; Oflocin; Oflodal; Oflodex; Oflodura; Oflox; Ofloxacin (JP15/USP/INN); Ofloxacin Otic; Ofloxacin [USAN:BAN:INN:JAN]; Ofloxacin, (S)-Isomer; Ofloxacina; Ofloxacina [DCIT]; Ofloxacine; Ofloxacine [French]; Ofloxacino; Ofloxacino [Spanish]; Ofloxacinum; Ofloxacinum [Latin]; Ofloxin; Ofus; Onexacin; Operan; Orocin; Otonil; Oxaldin; PT 01; Pharflox; Praxin; Puiritol; Qinolon; Qipro; Quinolon; Quotavil; Rilox; Ru-43280; Sinflo; Tabrin; Taravid; Tariflox; Tarivid; Telbit; Tructum; Uro Tarivid; Viotisone; Visiren; WP-0405; XED; Zanocin
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infections [ICD11:1A00-1H0Z] | Approved | [1] | |||
| Therapeutic Class |
Antibiotics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C18H20FN3O4
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| Canonical SMILES |
CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
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| InChI |
InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
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| InChIKey |
GSDSWSVVBLHKDQ-UHFFFAOYSA-N
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| CAS Number |
CAS 82419-36-1
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| Pharmaceutical Properties | Molecular Weight | 361.4 | Topological Polar Surface Area | 73.3 | ||
| Heavy Atom Count | 26 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 8 | |||
| XLogP |
-0.4
|
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| PubChem CID | ||||||
| PubChem SID |
11335896
,11361135
,11364080
,11366642
,11369204
,11372716
,11373806
,11377366
,11462107
,11466265
,11467385
,11485123
,11485970
,11489280
,11491314
,11492139
,11495000
,11533038
,12013736
,14876840
,17405462
,24278613
,24860450
,26612280
,26680409
,26747609
,26747610
,26747611
,26747612
,29223672
,3206370
,46507574
,47216794
,47291150
,47515336
,47589018
,47589019
,47959764
,48035139
,48259249
,48259250
,5025346
,597127
,7847519
,7891126
,7980182
,8027636
,8149812
,8152815
,9529
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| ChEBI ID |
CHEBI:7731
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | BCRP | Transporter Info | Breast cancer resistance protein | Substrate | [2] | |
| References | ||||||
| 1 | Ofloxacin was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. | |||||
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