Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00389
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| Drug Name |
Methylphenidate
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| Synonyms |
2-Piperidineacetic acid, .alpha.-phenyl-, methyl ester; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester; Alpha-Phenyl-2-piperidineacetic acid methyl ester; Alpha-Phenyl-alpha-(2-piperidyl)acetic acid methyl ester; Attenta (TN); Biphentin (TN); C 4311; Calocain; Centedein; Centedrin; Centredin; Concerta; Concerta (TN); D-methylphenidate HCl; Daytrana; Daytrana (TN); Equasym (TN); METHYLPHENIDATE (SEE ALSO: METHYLPHENIDATE HYDROCHLORIDE, CAS 298-59-9, NTPNO 10266-R); Meridil; Metadate; Metadate CD; Metadate ER; Metadate ER (TN); MethyPatch; Methyl (2-phenyl-2-(2-piperidyl)acetate); Methyl 2-phenyl-2-piperidin-2-ylacetate; Methyl alpha-phenyl-alpha-(2-piperidyl)acetate; Methyl alpha-phenyl-alpha-2-piperidinylacetate; Methyl phenidate; Methyl phenidyl acetate; Methyl phenidylacetate; Methyl phenyl(piperidin-2-yl)acetate; Methylfenidan; Methylin; Methylin (TN); Methylin ER; Methylofenidan; Methylphen; Methylphenidan; Methylphenidate (USAN/INN); Methylphenidate [INN:BAN]; Methylphenidatum; Methylphenidatum [INN-Latin]; Metilfenidato; Metilfenidato [INN-Spanish]; Metilfenidato [Italian]; Motiron (TN); PMS-Methylphenidate; Phenidylate; Plimasine; Riphenidate; Ritalin; Ritalin (TN); Ritalin LA; Ritalin LA (TN); Ritalin SR; Ritalin-SR; Ritaline; Ritcher works; Rubifen (TN); Tsentedrin
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| Drug Type |
Small molecular drug
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| Indication | Traumatic brain injury [ICD11:NA07.Z] | Approved | [1] | |||
| Therapeutic Class |
Central Nervous System Stimulants
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C14H19NO2
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| Canonical SMILES |
COC(=O)C(C1CCCCN1)C2=CC=CC=C2
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| InChI |
InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3
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| InChIKey |
DUGOZIWVEXMGBE-UHFFFAOYSA-N
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| CAS Number |
CAS 113-45-1
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| Pharmaceutical Properties | Molecular Weight | 233.31 | Topological Polar Surface Area | 38.3 | ||
| Heavy Atom Count | 17 | Rotatable Bond Count | 4 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
0.2
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| PubChem CID | ||||||
| PubChem SID |
103209574
,103858000
,103958410
,104305599
,10504398
,124954808
,127787857
,134337354
,134974024
,135709935
,136897384
,137007933
,142361369
,14798219
,160963768
,163411030
,178103810
,179148478
,216106193
,223897828
,226423048
,249807024
,249948308
,252404612
,26746622
,29223265
,46505929
,47206727
,48416258
,49854760
,5336253
,53789341
,57322165
,78286794
,7979945
,8152600
,85209963
,9405
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| ChEBI ID |
ChEBI:84276
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | GLYT2 | Transporter Info | Sodium- and chloride-dependent glycine transporter 2 | Substrate | [2] | |
| References | ||||||
| 1 | Methylphenidate was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013 Apr-Jun;34(2-3):197-219. | |||||
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