Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00327
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| Drug Name |
Benzbromarone
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| Synonyms |
(2-Ethyl-3-benzofuranyl)-(3,5-dibrom-4-hydroxyphenyl)keton; (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone; (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone; 2-Ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran; 3, 5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; 3,5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran; 3-[3,5-DIBROMO-4-HYDROXYBENZOYL]-2-ETHYLBENZOFURAN; AL, Benzbromaron; Acifugan; Aliud Brand of Benzbromarone; Azubromaron; Benzbromaron; Benzbromaron AL; Benzbromaron ratiopharm; Benzbromaron-ratiopharm; Benzbromarone (JP15/USAN/INN); Benzbromarone Aliud Brand; Benzbromarone Heumann Brand; Benzbromarone Sanfer Brand; Benzbromarone [USAN:INN:BAN]; Benzbromarone ratiopharm Brand; Benzbromaronratiopharm; Benzbromaronum; Benzbromaronum [INN-Latin]; Benzobromarona; Benzobromarona [INN-Spanish]; Besuric; Desuric; Exurate; Harolan; Heumann Brand of Benzbromarone; Hipurik; KETONE, 3,5-DIBROMO-4-HYDROXYPHENYL 2-ETHYL-3-BENZOFURANYL; L 2214; L 2214-Labaz; L-2214; L2214; MJ 10061; Methanone, (3; Minuric; NCI85433; Narcaricin; Normurat; Ratiopharm Brand of Benzbromarone; Sanfer Brand of Benzbromarone; Sanofi Winthrop Brand of Benzbromarone; Uricovac; Urinorm; Uroleap; Uroleap (TN)
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| Drug Type |
Small molecular drug
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| Indication | Gout [ICD11:FA25] | Approved | [1] | |||
| Structure |
|
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| 3D MOL | 2D MOL | |||||
| Formula |
C17H12Br2O3
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| Canonical SMILES |
CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br
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| InChI |
InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
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| InChIKey |
WHQCHUCQKNIQEC-UHFFFAOYSA-N
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| CAS Number |
CAS 3562-84-3
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| Pharmaceutical Properties | Molecular Weight | 424.1 | Topological Polar Surface Area | 50.4 | ||
| Heavy Atom Count | 22 | Rotatable Bond Count | 3 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
5.7
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| PubChem CID | ||||||
| PubChem SID |
10320943
,10321664
,103513016
,103914152
,11110651
,11446236
,11458917
,11461081
,11466398
,11467518
,11486156
,11533498
,122758
,15329540
,221763
,24424558
,24891861
,26653345
,26664708
,29221503
,4253342
,4572619
,46386951
,47291274
,47810917
,47959937
,48185143
,48259414
,48415612
,49681786
,49698460
,49988150
,50100155
,50103990
,50804618
,56422114
,57321259
,57653945
,76715662
,7848119
,8139271
,8151561
,855676
,85787503
,89471954
,92125465
,92308014
,92308634
,92722452
,99450936
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| ChEBI ID |
ChEBI:3023
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | MRP6 | Transporter Info | Multidrug resistance-associated protein 6 | Substrate | [2] | |
| References | ||||||
| 1 | A benefit-risk assessment of benzbromarone in the treatment of gout. Was its withdrawal from the market in the best interest of patients? Drug Saf. 2008;31(8):643-65. | |||||
| 2 | The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 3.A.1.208.10) | |||||
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