Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0547 Transporter Info
Gene Name KCNK4
Transporter Name Potassium channel subfamily K member 4
Gene ID
50801
UniProt ID
Q9NYG8
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Mycotoxins

  Aflatoxin B1

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 results in decreased methylation of KCNK4 gene [4]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Aflatoxin B1 results in increased methylation of KCNK4 intron [5]

Regulation Mechanism

 Transcription Factor Info

  aflatoxin B2

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aflatoxin B2 results in decreased methylation of KCNK4 intron [5]

Regulation Mechanism

 Transcription Factor Info

Chemical Compound

  Arachidonic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arachidonic Acid promotes the reaction KCNK4 protein results in increased transport of Potassium [6]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of KCNK4 5' UTR [7]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene affects the methylation of KCNK4 promoter [5]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Benzo(a)pyrene results in decreased methylation of KCNK4 promoter [7]

Regulation Mechanism

 Transcription Factor Info

  benzo(e)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 benzo(e)pyrene results in decreased methylation of KCNK4 intron [5]

Regulation Mechanism

 Transcription Factor Info

  Flufenamic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Flufenamic Acid promotes the reaction KCNK4 protein results in increased transport of Potassium [8]

Regulation Mechanism

 Transcription Factor Info

  licochalcone B

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 licochalcone B results in increased expression of KCNK4 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

  Mefenamic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Mefenamic Acid promotes the reaction KCNK4 protein results in increased transport of Potassium [8]

Regulation Mechanism

 Transcription Factor Info

  Methapyrilene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methapyrilene results in decreased methylation of KCNK4 intron [5]

Regulation Mechanism

 Transcription Factor Info

  Niflumic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Niflumic Acid promotes the reaction KCNK4 protein results in increased transport of Potassium [8]

Regulation Mechanism

 Transcription Factor Info

  Potassium

            5 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arachidonic Acid promotes the reaction KCNK4 protein results in increased transport of Potassium [6]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Flufenamic Acid promotes the reaction KCNK4 protein results in increased transport of Potassium [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 KCNK4 protein results in increased transport of Potassium [6]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 Mefenamic Acid promotes the reaction KCNK4 protein results in increased transport of Potassium [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 Niflumic Acid promotes the reaction KCNK4 protein results in increased transport of Potassium [8]

Regulation Mechanism

 Transcription Factor Info

Natural Product

  Resveratrol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Plant Extracts co-treated with Resveratrol results in decreased expression of KCNK4 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Testosterone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Testosterone inhibits the expression of KCNK4 [2]

Discontinued Drug

  Sipatrigine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sipatrigine inhibits the activity of KCNK4 [1]

Cell System

 Human embryonic kidney 293 cells (HEK293)-KCNK4

Acute Toxic Substance

  Cadmium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium increases the expression of KCNK4 [3]
References
1 Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem. 2016 Jun 9;59(11):5149-57.
2 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384.
3 Using expression profiling to understand the effects of chronic cadmium exposure on MCF-7 breast cancer cells. PLoS One. 2013 Dec 20;8(12):e84646.
4 Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
5 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
6 Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel. FEBS Lett. 2000;471(2-3):137-40.
7 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
8 Fenamates and diltiazem modulate lipid-sensitive mechano-gated 2P domain K(+) channels. Pflugers Arch. 2005;451(3):474-8.
9 Integrated miRNA and mRNA omics reveal the anti-cancerous mechanism of Licochalcone B on Human Hepatoma Cell HepG2. Food Chem Toxicol. 2021;150:112096.
10 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.