Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0537 Transporter Info
Gene Name RALBP1
Transporter Name RalBP1-associated Eps domain-containing protein 2
Gene ID
10928
UniProt ID
Q8NFH8
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Valproic Acid results in increased methylation of RALBP1 gene [30]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Selenium co-treated with Vitamin E results in decreased expression of RALBP1 mRNA [7]

Regulation Mechanism

 Transcription Factor Info

  1-Methyl-3-isobutylxanthine

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  3,4-dichloroaniline

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 3,4-dichloroaniline results in increased expression of RALBP1 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  4-hydroxy-2-nonenal

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 RALBP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal [14]

Regulation Mechanism

 Transcription Factor Info

  abrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 abrine results in decreased expression of RALBP1 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  Adenosine Triphosphate

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Adenosine Triphosphate co-treated with PRKCA protein results in increased phosphorylation of RALBP1 protein which results in increased transport of Doxorubicin [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Adenosine Triphosphate promotes the reaction RALBP1 protein affects the transport of Leukotriene C4 [17]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of RALBP1 3' UTR [19]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene results in increased methylation of RALBP1 promoter [19]

Regulation Mechanism

 Transcription Factor Info

  bisindolylmaleimide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisindolylmaleimide results in decreased phosphorylation of RALBP1 protein [16]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  bisphenol F

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  bisphenol S

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  CGP 52608

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CGP 52608 promotes the reaction RORA protein binds to RALBP1 gene [21]

Regulation Mechanism

 Transcription Factor Info

  Cisplatin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cisplatin co-treated with jinfukang results in increased expression of RALBP1 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

  Colchicine

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Colchicine inhibits the reaction RALBP1 protein affects the transport of Leukotriene C4 [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 RALBP1 protein affects the transport of Colchicine [17]

Regulation Mechanism

 Transcription Factor Info

  coumarin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 coumarin affects the phosphorylation of RALBP1 protein [20]

Regulation Mechanism

 Transcription Factor Info

  Dexamethasone

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  Doxorubicin

            7 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Adenosine Triphosphate co-treated with PRKCA protein results in increased phosphorylation of RALBP1 protein which results in increased transport of Doxorubicin [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 PRKCA protein affects the reaction RALBP1 protein affects the transport of and affects the susceptibility to Doxorubicin [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 RALBP1 protein affects the export of Doxorubicin [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 RALBP1 protein affects the transport of and affects the susceptibility to Doxorubicin [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 RALBP1 protein affects the transport of Doxorubicin [24]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 RALBP1 protein modified form affects the susceptibility to Doxorubicin [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 RALBP1 protein results in decreased susceptibility to Doxorubicin [14]

Regulation Mechanism

 Transcription Factor Info

  FR900359

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 FR900359 affects the phosphorylation of RALBP1 protein [25]

Regulation Mechanism

 Transcription Factor Info

  Fulvestrant

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fulvestrant results in increased methylation of RALBP1 gene [26]

Regulation Mechanism

 Transcription Factor Info

  Indomethacin

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in increased expression of RALBP1 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  Leukotriene C4

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Adenosine Triphosphate promotes the reaction RALBP1 protein affects the transport of Leukotriene C4 [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Colchicine inhibits the reaction RALBP1 protein affects the transport of Leukotriene C4 [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 RALBP1 protein affects the transport of Leukotriene C4 [17]

Regulation Mechanism

 Transcription Factor Info

  Palmitic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Palmitic Acid results in decreased phosphorylation of RALBP1 protein [27]

Regulation Mechanism

 Transcription Factor Info

  Selenium

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Selenium co-treated with Vitamin E results in decreased expression of RALBP1 mRNA [7]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Selenium results in decreased expression of RALBP1 mRNA [7]

Regulation Mechanism

 Transcription Factor Info

  Silicon Dioxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Silicon Dioxide results in decreased expression of RALBP1 mRNA [28]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in decreased expression of RALBP1 protein [10]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of RALBP1 mRNA [29]

Regulation Mechanism

 Transcription Factor Info

  Vanadates

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vanadates results in decreased expression of RALBP1 mRNA [31]

Regulation Mechanism

 Transcription Factor Info

Mycotoxins

  Aflatoxin B1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 results in decreased methylation of RALBP1 gene [18]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Copper Sulfate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Copper Sulfate affects the expression of RALBP1 [2]

  Valproic Acid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid affects the expression of RALBP1 [3]

  Urethane

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Urethane increases the expression of RALBP1 [4]

  Arsenic Trioxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arsenic Trioxide increases the expression of RALBP1 [5]

  Sunitinib

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sunitinib increases the expression of RALBP1 [6]

Drug in Phase 3 Trial

  Vitamin E

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vitamin E inhibits the expression of RALBP1 [7]

Drug in Phase 1 Trial

  Dihydrotestosterone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dihydrotestosterone increases the expression of RALBP1 [9]

  Sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium arsenite inhibits the expression of RALBP1 [10]

Investigative Drug

  Necrostatin-1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Necrostatin-1 inhibits the activity of RALBP1 [1]

Cell System

 Macrophage cells

Natural Product

  Selenium nanoparticles

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Selenium nanoparticles inhibits the expression of RALBP1 [7]

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution increases the expression of RALBP1 [11]

  Caffeine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Caffeine affects the phosphorylation of RALBP1 protein [20]

Regulation Mechanism

 Transcription Factor Info

  Quercetin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Quercetin results in decreased phosphorylation of RALBP1 protein [20]

Regulation Mechanism

 Transcription Factor Info

Herbicide

  Atrazine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Atrazine inhibits the expression of RALBP1 [8]
References
1 Salmonella-nduced miR-155 enhances necroptotic death in macrophage cells via targeting RIP1/3. Mol Med Rep. 2018 Dec;18(6):5133-5140.
2 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
3 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
4 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
5 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
6 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
7 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
8 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
9 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
10 The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest. Cell. 2019 Jan 10;176(1-2):391-403.e19.
11 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
12 Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles. PLoS One. 2017;12(6):e0179583.
13 Diuron metabolites and urothelial cytotoxicity: in vivo, in vitro and molecular approaches. Toxicology. 2013 Dec 15;314(2-3):238-46.
14 Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin. Biochem Pharmacol. 2005;70(3):481-8.
15 Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
16 The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer. FEBS Lett. 2005;579(21):4635-41.
17 RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. Int J Cancer. 2004;112(6):934-42.
18 Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
19 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
20 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022;449:116110.
21 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
22 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
23 Determinants of differential doxorubicin sensitivity between SCLC and NSCLC. FEBS Lett. 2006;580(9):2258-64.
24 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
25 Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
26 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
27 Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448.
28 Genome-wide DNA methylome and transcriptome changes induced by inorganic nanoparticles in human kidney cells after chronic exposure. Cell Biol Toxicol. 2022 Jan 1.
29 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
30 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
31 Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics. 2012 Aug;4(8):784-93.

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