Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0533 Transporter Info
Gene Name	ATP7B
Transporter Name	Copper-transporting ATPase 2
Gene ID	540
UniProt ID	P35670

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Approved Drug
Oxaliplatin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxaliplatin inhibits the expression of ATP7B		[2]
Copper Sulfate	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of ATP7B		[4]
Hydrogen Peroxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of ATP7B		[5]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Menadione affects the expression of ATP7B		[5]
Cytarabine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cytarabine inhibits the expression of ATP7B		[6]
Folic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Folic Acid inhibits the expression of ATP7B		[7]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of ATP7B		[8]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of ATP7B		[9]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of ATP7B		[10]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of ATP7B		[11]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of ATP7B		[12]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of ATP7B		[13]
Cisplatin	7 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin induces the activity of ATP7B		[14]
Drug Marketed but not Approved by US FDA
Zinc chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc chloride inhibits the expression of ATP7B		[3]
Drug in Phase 3 Trial
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Triclosan increases the expression of ATP7B		[22]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of ATP7B		[18]
Investigative Drug
Metribolone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Metribolone increases the expression of ATP7B		[19]
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of ATP7B		[20]
Beta-naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Beta-naphthoflavone inhibits the expression of ATP7B		[25]
Natural Product
Coal Ash	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coal Ash inhibits the expression of ATP7B		[16]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of ATP7B		[26]
Environmental toxicant
High copper levels	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	High copper levels induces the activity of ATP7B		[1]
Cell System	Triple-negative breast cancer cells-ATP7B
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of ATP7B		[18]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 affects the expression of ATP7B		[17]
DT Modulation2	Aflatoxin B1 results in decreased methylation of ATP7B gene		[32]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in increased methylation of ATP7B intron		[33]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide inhibits the expression of ATP7B		[24]
Paraquat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paraquat inhibits the expression of ATP7B		[27]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of ATP7B		[23]
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Water Pollutants, Chemical co-treated with Cadmium results in increased expression of ATP7B mRNA		[42]
Regulation Mechanism			Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel results in decreased expression of ATP7B mRNA		[68]
Regulation Mechanism			Transcription Factor Info
Health and Environmental Toxicant
Lead	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lead affects the expression of ATP7B		[21]
Chemical Compound
DT Modulation1	ATP7B protein affects the susceptibility to Oxaliplatin		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ATP7B protein results in decreased susceptibility to Copper Sulfate		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Copper Sulfate results in increased expression of ATP7B mRNA		[61]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Copper Sulfate results in increased expression of ATP7B protein		[61]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Hydrogen Peroxide promotes the reaction CLU protein binds to ATP7B protein		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid results in decreased methylation of ATP7B gene		[13]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ATP7B mRNA affects the susceptibility to Cisplatin		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATP7B protein binds to and results in increased metabolism of Cisplatin		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ATP7B protein results in decreased susceptibility to Cisplatin		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	ATP7B protein results in increased secretion of Cisplatin		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Cisplatin results in decreased expression of ATP7B mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Cisplatin results in increased stability of and results in increased activity of and affects the localization of ATP7B protein polymorphism		[47]
Regulation Mechanism			Transcription Factor Info
Cupric oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cupric oxide increases the expression of ATP7B		[15]
Regulation Mechanism	via enhancement of Metal regulatory transcription factor 1 (MTF1)		Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
DT Modulation1	AR protein promotes the reaction Metribolone results in increased expression of ATP7B mRNA		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ATP7B mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of ATP7B intron		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of ATP7B 3' UTR		[36]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ATP7B mRNA		[28]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of ATP7B mRNA		[29]
Regulation Mechanism			Transcription Factor Info
Adenosine Triphosphate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Adenosine Triphosphate results in increased phosphorylation of ATP7B protein		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Copper co-treated with Adenosine Triphosphate results in increased phosphorylation of ATP7B protein		[31]
Regulation Mechanism			Transcription Factor Info
Ammonium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ammonium Chloride inhibits the reaction CLU protein results in increased degradation of ATP7B protein modified form		[34]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of ATP7B mRNA		[35]
Regulation Mechanism			Transcription Factor Info
bathocuproine sulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Penicillamine co-treated with bathocuproine sulfonate promotes the reaction CLU protein binds to ATP7B protein		[34]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased methylation of ATP7B intron		[33]
Regulation Mechanism			Transcription Factor Info
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of ATP7B protein		[37]
Regulation Mechanism			Transcription Factor Info
beta-Naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-Naphthoflavone results in decreased expression of ATP7B mRNA		[25]
Regulation Mechanism			Transcription Factor Info
bicinchoninic acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bicinchoninic acid results in decreased phosphorylation of ATP7B protein		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Copper inhibits the reaction bicinchoninic acid results in decreased phosphorylation of ATP7B protein		[38]
Regulation Mechanism			Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in increased methylation of ATP7B gene		[39]
Regulation Mechanism			Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in decreased methylation of ATP7B gene		[39]
Regulation Mechanism			Transcription Factor Info
Brefeldin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Brefeldin A inhibits the reaction Copper affects the localization of ATP7B protein		[40]
Regulation Mechanism			Transcription Factor Info
bufotalin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bufotalin results in decreased expression of ATP7B mRNA		[41]
Regulation Mechanism			Transcription Factor Info
Carboplatin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7B protein binds to and results in increased metabolism of Carboplatin		[43]
Regulation Mechanism			Transcription Factor Info
CID755673	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CID755673 results in decreased phosphorylation of ATP7B protein		[37]
Regulation Mechanism			Transcription Factor Info
Copper	32 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATOX1 protein binds to Copper which binds to ATP7B protein		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATOX1 protein binds to Copper which binds to ATP7B protein inhibits the reaction ATOX1 protein binds to Copper		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ATOX1 protein binds to Copper which binds to ATP7B protein promotes the reaction ATP7B protein binds to Copper		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	ATP7B gene mutant form inhibits the reaction Copper results in increased expression of HMOX1 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	ATP7B gene mutant form inhibits the reaction Copper results in increased expression of MT1X mRNA		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	ATP7B gene mutant form promotes the reaction Copper results in decreased abundance of Heme		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	ATP7B gene mutant form promotes the reaction Copper results in decreased abundance of protoporphyrin IX		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	ATP7B gene mutant form results in decreased abundance of Copper		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	ATP7B gene mutant form results in increased susceptibility to Copper		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	ATP7B protein affects the transport of Copper		[52]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	ATP7B protein binds to Copper		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	ATP7B protein mutant form results in decreased susceptibility to Copper		[53]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	ATP7B protein mutant form results in increased abundance of Copper		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	ATP7B protein mutant form results in increased oxidation of ATP7B protein inhibits the reaction ATP7B protein binds to Copper		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	ATP7B protein polymorphism affects the localization of Copper		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation16	ATP7B protein results in decreased abundance of Copper		[56]
Regulation Mechanism			Transcription Factor Info
DT Modulation17	ATP7B protein results in decreased susceptibility to cupric chloride results in increased abundance of Copper		[57]
Regulation Mechanism			Transcription Factor Info
DT Modulation18	ATP7B protein results in increased export of Copper		[58]
Regulation Mechanism			Transcription Factor Info
DT Modulation19	ATP7B protein results in increased transport of Copper		[59]
Regulation Mechanism			Transcription Factor Info
DT Modulation20	ATP7B protein results in increased uptake of cupric chloride results in increased abundance of Copper		[57]
Regulation Mechanism			Transcription Factor Info
DT Modulation21	Brefeldin A inhibits the reaction Copper affects the localization of ATP7B protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation22	CLU protein co-treated with ATP7B protein results in decreased export of Copper		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation23	Copper affects the localization of ATP7B protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation24	Copper binds to ATP7B protein		[52]
Regulation Mechanism			Transcription Factor Info
DT Modulation25	Copper co-treated with Adenosine Triphosphate results in increased phosphorylation of ATP7B protein		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation26	Copper inhibits the reaction bicinchoninic acid results in decreased phosphorylation of ATP7B protein		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation27	Copper results in increased phosphorylation of ATP7B protein		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation28	Copper results in increased stability of and results in increased activity of and affects the localization of ATP7B protein polymorphism		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation29	INS protein inhibits the reaction ATP7B protein affects the export of Copper		[60]
Regulation Mechanism			Transcription Factor Info
DT Modulation30	Nocodazole inhibits the reaction Copper affects the localization of ATP7B protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation31	Penicillamine inhibits the reaction ATP7B gene mutant form results in decreased abundance of Copper		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation32	Zinc Sulfate inhibits the reaction ATP7B gene mutant form results in decreased abundance of Copper		[51]
Regulation Mechanism			Transcription Factor Info
cupric chloride	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7B protein results in decreased susceptibility to cupric chloride		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATP7B protein results in decreased susceptibility to cupric chloride results in increased abundance of Copper		[57]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ATP7B protein results in increased uptake of cupric chloride results in increased abundance of Copper		[57]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	cupric chloride affects the localization of ATP7B protein		[62]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	cupric chloride promotes the reaction CLU protein binds to ATP7B protein		[34]
Regulation Mechanism			Transcription Factor Info
cupric oxide	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric oxide affects the localization of ATP7B protein		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	cupric oxide analog results in increased expression of ATP7B mRNA		[61]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	cupric oxide analog results in increased expression of ATP7B protein		[61]
Regulation Mechanism			Transcription Factor Info
Diamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diamide promotes the reaction CLU protein binds to ATP7B protein		[34]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ATP7B mRNA		[28]
Regulation Mechanism			Transcription Factor Info
epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ATP7B mRNA		[63]
Regulation Mechanism			Transcription Factor Info
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of ATP7B mRNA		[64]
Regulation Mechanism			Transcription Factor Info
Fluorouracil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7B mRNA results in increased susceptibility to Fluorouracil		[65]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in increased phosphorylation of ATP7B protein		[66]
Regulation Mechanism			Transcription Factor Info
Glutathione	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7B gene mutant form results in decreased abundance of Glutathione		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Penicillamine inhibits the reaction ATP7B gene mutant form results in decreased abundance of Glutathione		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Zinc Sulfate inhibits the reaction ATP7B gene mutant form results in decreased abundance of Glutathione		[51]
Regulation Mechanism			Transcription Factor Info
Heme	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7B gene mutant form promotes the reaction Copper results in decreased abundance of Heme		[50]
Regulation Mechanism			Transcription Factor Info
Magnesium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Magnesium results in increased phosphorylation of ATP7B protein		[30]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Manganese results in increased phosphorylation of ATP7B protein		[30]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased methylation of ATP7B intron		[33]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of ATP7B mRNA		[67]
Regulation Mechanism			Transcription Factor Info
Nocodazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nocodazole inhibits the reaction Copper affects the localization of ATP7B protein		[40]
Regulation Mechanism			Transcription Factor Info
Ozone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Air Pollutants results in increased abundance of Ozone which affects the expression of ATP7B mRNA		[69]
Regulation Mechanism			Transcription Factor Info
Penicillamine	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Penicillamine co-treated with ATP7B gene mutant form results in decreased activity of CAT protein		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Penicillamine co-treated with bathocuproine sulfonate promotes the reaction CLU protein binds to ATP7B protein		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Penicillamine inhibits the reaction ATP7B gene mutant form results in decreased abundance of Copper		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Penicillamine inhibits the reaction ATP7B gene mutant form results in decreased abundance of Glutathione		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Penicillamine inhibits the reaction ATP7B gene mutant form results in decreased expression of CP protein		[51]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ATP7B mRNA		[63]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	potassium chromate(VI) results in decreased expression of ATP7B mRNA		[63]
Regulation Mechanism			Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of ATP7B mRNA		[64]
Regulation Mechanism			Transcription Factor Info
protoporphyrin IX	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7B gene mutant form promotes the reaction Copper results in decreased abundance of protoporphyrin IX		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATP7B gene mutant form results in decreased chemical synthesis of protoporphyrin IX		[50]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of ATP7B gene		[70]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in decreased expression of ATP7B mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Tetradecanoylphorbol Acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKD1 protein which results in increased expression of ATP7B protein		[37]
Regulation Mechanism			Transcription Factor Info
tetrathiomolybdate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tetrathiomolybdate results in decreased expression of ATP7B protein		[71]
Regulation Mechanism			Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 affects the expression of ATP7B mRNA		[5]
Regulation Mechanism			Transcription Factor Info
zinc chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zinc chloride results in decreased expression of ATP7B mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	zinc chloride results in increased expression of ATP7B mRNA		[3]
Regulation Mechanism			Transcription Factor Info
Zinc Sulfate	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc Sulfate co-treated with ATP7B gene mutant form results in decreased activity of CAT protein		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Zinc Sulfate inhibits the reaction ATP7B gene mutant form results in decreased abundance of Copper		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Zinc Sulfate inhibits the reaction ATP7B gene mutant form results in decreased abundance of Glutathione		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Zinc Sulfate inhibits the reaction ATP7B gene mutant form results in decreased expression of CP protein		[51]
Regulation Mechanism			Transcription Factor Info

References
1	Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis. Mol Cancer Ther. 2019 May;18(5):873-885.
2	Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT29 colon cancer cells. Int J Oncol. 2006 Jul;29(1):225-35.
3	Analysis of differential gene-regulatory responses to zinc in human intestinal and placental cell lines. Br J Nutr. 2009 May;101(10):1474-83.
4	Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
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