Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0513 Transporter Info
Gene Name	KCNQ1
Transporter Name	Voltage-gated potassium channel Kv7.1
Gene ID	3784
UniProt ID	P51787

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Approved Drug
Bupivacaine	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bupivacaine inhibits the activity of KCNQ1		[1]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of KCNQ1		[2]
Arsenic	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the expression of KCNQ1		[3]
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dronabinol inhibits the expression of KCNQ1		[4]
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of KCNQ1		[5]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of KCNQ1		[6]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of KCNQ1		[7]
Daunorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Daunorubicin inhibits the expression of KCNQ1		[8]
Mitoxantrone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mitoxantrone inhibits the expression of KCNQ1		[8]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of KCNQ1		[9]
Indapamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Indapamide blocks the activity of KCNQ1		[10]
Drug in Phase 3 Trial
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sulforafan inhibits the expression of KCNQ1		[19]
Volinanserin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Volinanserin inhibits the activity of KCNQ1		[20]
Drug in Phase 2 Trial
MS-275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of KCNQ1		[16]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of KCNQ1		[12]
Investigative Drug
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate inhibits the expression of KCNQ1		[15]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of KCNQ1		[17]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of KCNQ1		[18]
DT Modulation2	Aflatoxin B1 affects the methylation of KCNQ1 intron		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased methylation of KCNQ1 gene		[18]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 affects the methylation of KCNQ1 intron		[27]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Acrylamide	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide inhibits the activity of KCNQ1		[11]
Carcinogen
DT Modulation1	Arsenic affects the expression of and affects the methylation of KCNQ1		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Arsenic affects the methylation of KCNQ1 gene		[3]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of KCNQ1		[18]
Health and Environmental Toxicant
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium increases the expression of KCNQ1		[13]
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of KCNQ1		[14]
Chemical Compound
DT Modulation1	Bupivacaine results in decreased activity of KCNQ1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Bupivacaine results in decreased activity of KCNQ1 protein binds to KCNE1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	KCNE1 protein inhibits the reaction KCNQ1 protein mutant form results in increased susceptibility to Bupivacaine		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	KCNQ1 protein mutant form results in increased susceptibility to Bupivacaine		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol co-treated with TGFB1 protein results in decreased expression of KCNQ1 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of KCNQ1 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid results in increased methylation of KCNQ1 gene		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Acrylamide analog results in decreased activity of KCNQ1 protein		[11]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Acrylamide results in increased expression of KCNQ1 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	KCNE1 protein promotes the reaction Acrylamide analog results in decreased activity of KCNQ1 protein		[11]
Regulation Mechanism			Transcription Factor Info
Pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pentanal increases the expression of KCNQ1		[14]
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of KCNQ1 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of KCNQ1 intron		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of KCNQ1 promoter		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased expression of KCNQ1 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Benzo(a)pyrene results in increased methylation of KCNQ1 exon		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Benzo(a)pyrene results in increased methylation of KCNQ1 gene		[18]
Regulation Mechanism			Transcription Factor Info
1-Methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium results in increased expression of KCNQ1 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of KCNQ1 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of KCNQ1 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane results in decreased activity of KCNQ1 protein		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane results in decreased activity of KCNQ1 protein binds to KCNE1 protein		[22]
Regulation Mechanism			Transcription Factor Info
7,8-benzoquinoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-benzoquinoline results in increased activity of KCNQ1 protein		[23]
Regulation Mechanism			Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of KCNQ1 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in increased expression of KCNQ1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
Aprindine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	KCNQ1 gene affects the susceptibility to Aprindine		[28]
Regulation Mechanism			Transcription Factor Info
Atenolol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	KCNQ1 gene affects the susceptibility to Atenolol		[28]
Regulation Mechanism			Transcription Factor Info
Barium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Barium results in decreased activity of KCNQ1 protein binds to KCNE1 protein		[22]
Regulation Mechanism			Transcription Factor Info
barium chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	barium chloride results in decreased activity of KCNQ1 protein binds to KCNE1 protein		[22]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene affects the methylation of KCNQ1 intron		[27]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in decreased methylation of KCNQ1 gene		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased methylation of KCNQ1 gene		[32]
Regulation Mechanism			Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in decreased methylation of KCNQ1 gene		[32]
Regulation Mechanism			Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in decreased expression of KCNQ1 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to KCNQ1 gene		[33]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of KCNQ1 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of KCNQ1 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of KCNQ1 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
entinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of KCNQ1 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in decreased methylation of KCNQ1 gene		[32]
Regulation Mechanism			Transcription Factor Info
HMR 1556	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	HMR 1556 results in decreased activity of KCNQ1 protein binds to KCNE1 protein		[22]
Regulation Mechanism			Transcription Factor Info
Isoproterenol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isoproterenol results in increased activity of KCNQ1 protein binds to KCNE1 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction Isoproterenol results in increased activity of KCNQ1 protein binds to KCNE1 protein		[22]
Regulation Mechanism			Transcription Factor Info
Mepivacaine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mepivacaine results in decreased activity of KCNQ1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Mepivacaine results in decreased activity of KCNQ1 protein binds to KCNE1 protein		[1]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene affects the methylation of KCNQ1 intron		[27]
Regulation Mechanism			Transcription Factor Info
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction Isoproterenol results in increased activity of KCNQ1 protein binds to KCNE1 protein		[22]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of KCNQ1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Ozone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Air Pollutants results in increased abundance of Ozone which affects the expression of KCNQ1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pentanal results in increased expression of KCNQ1 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
Potassium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	KCNQ1 protein binds to KCNE1 protein which affects the transport of Potassium		[22]
Regulation Mechanism			Transcription Factor Info
Propranolol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	KCNQ1 gene affects the susceptibility to Propranolol		[28]
Regulation Mechanism			Transcription Factor Info
Ropivacaine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ropivacaine results in decreased activity of KCNQ1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Ropivacaine results in decreased activity of KCNQ1 protein binds to KCNE1 protein		[1]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of KCNQ1 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of KCNQ1 gene		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in decreased expression of KCNQ1 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
sulforaphane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in decreased expression of KCNQ1 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
Terfenadine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	KCNE1 protein inhibits the reaction KCNQ1 protein mutant form results in increased susceptibility to Terfenadine		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	KCNQ1 protein mutant form results in increased susceptibility to Terfenadine		[1]
Regulation Mechanism			Transcription Factor Info
Trazodone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trazodone results in decreased activity of KCNQ1 protein		[39]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of KCNQ1 mRNA		[34]
Regulation Mechanism			Transcription Factor Info

References
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3	Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106.
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6	Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
7	Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
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11	The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels. Neuropharmacology. 2006 Nov;51(6):1068-77.
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15	A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
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19	Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047.
20	Current and novel approaches to the drug treatment of schizophrenia. J Med Chem. 2001 Feb 15;44(4):477-501.
21	The intermediate conductance Ca2+-activated K+ channel inhibitor TRAM-34 stimulates proliferation of breast cancer cells via activation of oestrogen receptors. Br J Pharmacol. 2010;159(3):650-8.
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23	Mechanisms of anion secretion in Calu-3 human airway epithelial cells by 7,8-benzoquinoline. Br J Pharmacol. 2003;140(1):81-90.
24	Mechanistic profiling of the cAMP-dependent steroidogenic pathway in the H295R endocrine disrupter screening system: new endpoints for toxicity testing. Toxicol Lett. 2012;208(2):174-84.
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Detail Information of Exogenous Modulation

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