Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0512 Transporter Info
Gene Name	KCNMA1
Transporter Name	Calcium-activated potassium channel subunit alpha-1
Gene ID	3778
UniProt ID	Q12960

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Dietary Constituent
Calcium	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	KCNMA1 mRNA alternative form results in increased susceptibility to Calcium		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	KCNMB1 protein co-treated with KCNMA1 protein results in increased transport of Calcium		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Lithocholic Acid promotes the reaction KCNMB1 protein co-treated with KCNMA1 protein results in increased transport of Calcium		[34]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Estradiol	7 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the activity of KCNMA1		[1]
Progesterone	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the activity of KCNMA1		[1]
Amiodarone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Amiodarone increases the expression of KCNMA1		[2]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of KCNMA1		[3]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of KCNMA1		[4]
Methotrexate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methotrexate increases the expression of KCNMA1		[5]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Temozolomide inhibits the expression of KCNMA1		[6]
Malathion	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Malathion inhibits the expression of KCNMA1		[7]
Cisplatin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of KCNMA1		[8]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A inhibits the expression of KCNMA1		[10]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of KCNMA1		[13]
Dihydrotestosterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dihydrotestosterone increases the expression of KCNMA1		[14]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of KCNMA1		[9]
Investigative Drug
Tetraethylammonium	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetraethylammonium inhibits the activity of KCNMA1		[20]
Patented Pharmaceutical Agent
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG-001 increases the expression of KCNMA1		[12]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of KCNMA1		[19]
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of KCNMA1		[18]
Biotoxin
Iberiotoxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Iberiotoxin inhibits the activity of KCNMA1		[20]
iberiotoxin	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	iberiotoxin inhibits the reaction estradiol-bovine serum albumin results in increased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	iberiotoxin inhibits the reaction Estradiol results in increased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	iberiotoxin results in decreased activity of KCNMA1 protein		[41]
Regulation Mechanism			Transcription Factor Info
T-2 Toxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	T-2 Toxin results in increased expression of KCNMA1 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
Environmental toxicant
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A increases the expression of KCNMA1		[17]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of KCNMA1		[18]
DT Modulation2	Aflatoxin B1 affects the methylation of KCNMA1 intron		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in decreased methylation of KCNMA1 exon		[23]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 affects the methylation of KCNMA1 intron		[23]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide inhibits the expression of KCNMA1		[18]
Carcinogen
Benzo(a)pyrene	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of KCNMA1		[18]
Arsenic	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of KCNMA1 gene		[26]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of KCNMA1 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of KCNMA1 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Cadmium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of KCNMA1 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of KCNMA1 protein		[22]
Regulation Mechanism			Transcription Factor Info
Nickel	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel affects the expression of KCNMA1 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Nickel results in decreased expression of KCNMA1 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	trichostatin A inhibits the reaction Nickel affects the expression of KCNMA1 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
DT Modulation1	Malathion results in increased methylation of KCNMA1 promoter		[7]
Regulation Mechanism			Transcription Factor Info
Endosulfan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Endosulfan inhibits the expression of KCNMA1		[15]
Clothianidin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Clothianidin inhibits the expression of KCNMA1		[18]
Health and Environmental Toxicant
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate increases the expression of KCNMA1		[16]
Chemical Compound
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of KCNMA1 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estradiol co-treated with TGFB1 protein results in increased expression of KCNMA1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Estradiol results in increased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	iberiotoxin inhibits the reaction Estradiol results in increased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Progesterone inhibits the reaction Estradiol results in increased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Tetraethylammonium inhibits the reaction Estradiol results in increased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of KCNMA1 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Progesterone inhibits the reaction Estradiol results in increased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Progesterone results in decreased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Progesterone results in increased expression of KCNMA1 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Progesterone results in increased expression of KCNMA1 protein		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cisplatin promotes the reaction jinfukang results in decreased expression of KCNMA1 mRNA		[8]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	jinfukang promotes the reaction Cisplatin results in decreased expression of KCNMA1 mRNA		[8]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Piroxicam co-treated with Cisplatin results in increased expression of KCNMA1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
Pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pentanal increases the expression of KCNMA1		[11]
DT Modulation1	Benzo(a)pyrene affects the methylation of KCNMA1 intron		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of KCNMA1 promoter		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased methylation of KCNMA1 3' UTR		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Benzo(a)pyrene results in increased methylation of KCNMA1 exon		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Tetraethylammonium inhibits the reaction estradiol-bovine serum albumin results in increased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Tetraethylammonium inhibits the reaction Estradiol results in increased activity of KCNMA1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Tetraethylammonium promotes the reaction Glucose results in decreased activity of KCNMA1 protein binds to KCNMB1 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Tetraethylammonium results in decreased activity of KCNMA1 protein binds to KCNMB1 protein		[40]
Regulation Mechanism			Transcription Factor Info
1-Methyl-3-isobutylxanthine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin results in decreased expression of KCNMA1 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
2-bromopalmitate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of KCNMA1 protein		[22]
Regulation Mechanism			Transcription Factor Info
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction JAK2 protein results in increased activity of KCNMA1 protein mutant form		[24]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of KCNMA1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene affects the methylation of KCNMA1 intron		[23]
Regulation Mechanism			Transcription Factor Info
beta-methylcholine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-methylcholine affects the expression of KCNMA1 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
bisphenol A	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant affects the methylation of KCNMA1 gene		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased expression of KCNMA1 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	bisphenol A results in decreased methylation of KCNMA1 gene		[30]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of KCNMA1 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of KCNMA1 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased expression of KCNMA1 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to KCNMA1 gene		[35]
Regulation Mechanism			Transcription Factor Info
clothianidin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	clothianidin results in decreased expression of KCNMA1 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin results in decreased expression of KCNMA1 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
Fulvestrant	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant affects the methylation of KCNMA1 gene		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Fulvestrant results in increased methylation of KCNMA1 gene		[30]
Regulation Mechanism			Transcription Factor Info
Glucose	7 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glucose inhibits the reaction KCNMA1 protein binds to KCNMB1 protein which results in decreased expression of BCL2 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glucose results in decreased activity of KCNMA1 protein binds to KCNMB1 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NS 1619 inhibits the reaction Glucose inhibits the reaction KCNMA1 protein binds to KCNMB1 protein which results in decreased expression of BCL2 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NS 1619 inhibits the reaction Glucose results in decreased activity of KCNMA1 protein binds to KCNMB1 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Tamoxifen inhibits the reaction Glucose inhibits the reaction KCNMA1 protein binds to KCNMB1 protein which results in decreased expression of BCL2 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Tamoxifen inhibits the reaction Glucose results in decreased activity of KCNMA1 protein binds to KCNMB1 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Tetraethylammonium promotes the reaction Glucose results in decreased activity of KCNMA1 protein binds to KCNMB1 protein		[40]
Regulation Mechanism			Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in increased expression of KCNMA1 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin results in decreased expression of KCNMA1 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
lasiocarpine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	lasiocarpine results in decreased expression of KCNMA1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
Lithocholic Acid	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	KCNMA1 mRNA alternative form results in increased susceptibility to Lithocholic Acid		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	KCNMB1 protein co-treated with KCNMA1 protein results in increased susceptibility to Lithocholic Acid		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Lithocholic Acid promotes the reaction KCNMB1 protein co-treated with KCNMA1 protein results in increased transport of Calcium		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Lithocholic Acid results in increased activity of KCNMB1 protein co-treated with KCNMA1 protein		[34]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of KCNMA1 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of KCNMA1 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene affects the methylation of KCNMA1 intron		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Methapyrilene results in decreased expression of KCNMA1 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Methapyrilene results in increased expression of KCNMA1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of KCNMA1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
Mustard Gas	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mustard Gas results in decreased expression of KCNMA1 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
N-Nitrosopyrrolidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N-Nitrosopyrrolidine results in decreased expression of KCNMA1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
NS 1619	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NS 1619 binds to and results in increased activity of KCNMA1 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NS 1619 inhibits the reaction Glucose inhibits the reaction KCNMA1 protein binds to KCNMB1 protein which results in decreased expression of BCL2 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NS 1619 inhibits the reaction Glucose results in decreased activity of KCNMA1 protein binds to KCNMB1 protein		[40]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of KCNMA1 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Paclitaxel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	KCNMA1 protein affects the susceptibility to Paclitaxel		[48]
Regulation Mechanism			Transcription Factor Info
pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pentanal results in increased expression of KCNMA1 mRNA		[11]
Regulation Mechanism			Transcription Factor Info
Piroxicam	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Piroxicam co-treated with Cisplatin results in increased expression of KCNMA1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
propionaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	propionaldehyde results in increased expression of KCNMA1 mRNA		[11]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of KCNMA1 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
S-Nitrosoglutathione	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-Nitrosoglutathione results in increased expression of KCNMA1 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of KCNMA1 gene		[52]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in decreased expression of KCNMA1 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of KCNMA1 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of KCNMA1 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Tamoxifen	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tamoxifen inhibits the reaction Glucose inhibits the reaction KCNMA1 protein binds to KCNMB1 protein which results in decreased expression of BCL2 protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Tamoxifen inhibits the reaction Glucose results in decreased activity of KCNMA1 protein binds to KCNMB1 protein		[40]
Regulation Mechanism			Transcription Factor Info
tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A results in increased expression of KCNMA1 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in increased expression of KCNMA1 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
Topotecan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	KCNMA1 protein affects the susceptibility to Topotecan		[48]
Regulation Mechanism			Transcription Factor Info
trans-10,cis-12-conjugated linoleic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trans-10,cis-12-conjugated linoleic acid results in decreased expression of KCNMA1 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A inhibits the reaction Nickel affects the expression of KCNMA1 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A results in decreased expression of KCNMA1 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
Vanadates	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vanadates results in increased expression of KCNMA1 mRNA		[56]
Regulation Mechanism			Transcription Factor Info

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