Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0502 Transporter Info
Gene Name	SLCO4A1
Transporter Name	Organic anion transporting polypeptide 4A1
Gene ID	28231
UniProt ID	Q96BD0

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Approved Drug
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of SLCO4A1		[1]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the expression of SLCO4A1		[2]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLCO4A1		[3]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLCO4A1		[4]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid affects the expression of SLCO4A1		[5]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLCO4A1		[6]
Malathion	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Malathion increases the expression of SLCO4A1		[7]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLCO4A1		[8]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLCO4A1		[9]
MS-275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of SLCO4A1		[20]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin increases the expression of SLCO4A1		[11]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLCO4A1		[16]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLCO4A1		[28]
Drug in Preclinical Test
MRK-003	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MRK-003 increases the expression of SLCO4A1		[10]
Gardiquimod	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gardiquimod increases the expression of SLCO4A1		[21]
Investigative Drug
Milchsaure	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Milchsaure inhibits the expression of SLCO4A1		[25]
Estrone sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estrone sulfate modulates the activity of SLCO4A1		[29]
Patented Pharmaceutical Agent
K-7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K-7174 inhibits the expression of SLCO4A1		[14]
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG-001 inhibits the expression of SLCO4A1		[19]
Natural Product
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of SLCO4A1		[23]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLCO4A1		[24]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Caffeine results in decreased phosphorylation of SLCO4A1 protein		[41]
Regulation Mechanism			Transcription Factor Info
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Plant Extracts co-treated with Resveratrol results in decreased expression of SLCO4A1 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Oxyquinoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxyquinoline increases the expression of SLCO4A1		[11]
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium increases the expression of SLCO4A1		[12]
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Formaldehyde inhibits the expression of SLCO4A1		[13]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide inhibits the expression of SLCO4A1		[27]
Carcinogen
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate inhibits the expression of SLCO4A1		[13]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLCO4A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLCO4A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Fungicide
Enilconazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Enilconazole increases the expression of SLCO4A1		[26]
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos inhibits the expression of SLCO4A1		[22]
Health and Environmental Toxicant
Lead	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lead increases the expression of SLCO4A1		[12]
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde increases the expression of SLCO4A1		[17]
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLCO4A1		[18]
Herbicide
Diuron	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diuron increases the expression of SLCO4A1		[15]
Chemical Compound
DT Modulation1	Cyclosporine results in increased expression of SLCO4A1 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid results in increased methylation of SLCO4A1 gene		[58]
Regulation Mechanism			Transcription Factor Info
Pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pentanal increases the expression of SLCO4A1		[17]
3,4-dichloroaniline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	3,4-dichloroaniline results in increased expression of SLCO4A1 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
3-iodothyronamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLCO4A1 mRNA affects the uptake of 3-iodothyronamine		[30]
Regulation Mechanism			Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in decreased expression of SLCO4A1 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLCO4A1 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLCO4A1 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLCO4A1 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
Aldehydes	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aldehydes results in increased expression of SLCO4A1 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite results in increased expression of SLCO4A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of SLCO4A1 5' UTR		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of SLCO4A1 exon		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased methylation of SLCO4A1 promoter		[37]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased expression of SLCO4A1 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased methylation of SLCO4A1 gene		[39]
Regulation Mechanism			Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in increased expression of SLCO4A1 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased expression of SLCO4A1 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in increased expression of SLCO4A1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	coumarin results in decreased phosphorylation of SLCO4A1 protein		[41]
Regulation Mechanism			Transcription Factor Info
cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric chloride results in increased expression of SLCO4A1 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Diazinon	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diazinon results in increased methylation of SLCO4A1 gene		[45]
Regulation Mechanism			Transcription Factor Info
Dichlorodiphenyl Dichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene results in decreased expression of SLCO4A1 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in decreased expression of SLCO4A1 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLCO4A1 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
enilconazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	enilconazole results in increased expression of SLCO4A1 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of SLCO4A1 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLCO4A1 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with TGFB1 protein results in decreased expression of SLCO4A1 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estradiol results in increased expression of SLCO4A1 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in decreased phosphorylation of SLCO4A1 protein		[48]
Regulation Mechanism			Transcription Factor Info
gardiquimod	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	gardiquimod results in increased expression of SLCO4A1 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Protein Kinase Inhibitors inhibits the reaction gardiquimod results in increased expression of SLCO4A1 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in decreased expression of SLCO4A1 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K 7174 results in decreased expression of SLCO4A1 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
Lactic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lactic Acid results in decreased expression of SLCO4A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
lead acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	lead acetate results in decreased expression of SLCO4A1 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Manganese	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased abundance of Manganese which results in increased expression of SLCO4A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLCO4A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
manganese chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased abundance of Manganese which results in increased expression of SLCO4A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLCO4A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in decreased expression of SLCO4A1 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
Mitoxantrone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLCO4A1 protein affects the susceptibility to Mitoxantrone		[49]
Regulation Mechanism			Transcription Factor Info
monomethylarsonous acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	monomethylarsonous acid results in increased expression of SLCO4A1 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
MRK 003	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MRK 003 results in increased expression of SLCO4A1 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
nickel sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nickel sulfate results in increased expression of SLCO4A1 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLCO4A1 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of SLCO4A1 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pentanal results in increased expression of SLCO4A1 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in decreased expression of SLCO4A1 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) results in increased expression of SLCO4A1 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
propionaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	propionaldehyde results in increased expression of SLCO4A1 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of SLCO4A1 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Silicon Dioxide results in increased expression of SLCO4A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLCO4A1 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLCO4A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLCO4A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium arsenite results in increased expression of SLCO4A1 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in increased expression of SLCO4A1 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
Vanadates	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vanadates results in decreased expression of SLCO4A1 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
Vanadium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vanadium results in decreased expression of SLCO4A1 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
withaferin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	withaferin A results in increased expression of SLCO4A1 mRNA		[60]
Regulation Mechanism			Transcription Factor Info

References
1	Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
2	Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
3	Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
4	Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
5	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
6	Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975.
7	Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259.
8	Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423.
9	Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
10	The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res. 2010 Dec 15;16(24):6060-70.
11	Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
12	Heavy metal influence on BDE-47 uptake in the human KERTr keratinocyte cell line. Environ Toxicol. 2014 Mar;29(3):354-61.
13	Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
14	A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS One. 2013 Sep 27;8(9):e75568.
15	Diuron metabolites and urothelial cytotoxicity: in vivo, in vitro and molecular approaches. Toxicology. 2013 Dec 15;314(2-3):238-46.
16	From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
17	Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
18	Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
19	Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
20	A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
21	Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. J Immunol. 2017 Feb 1;198(3):1308-1319.
22	Molecular mechanisms of discrotophos-induced toxicity in HepG2 cells: The role of CSA in oxidative stress. Food Chem Toxicol. 2017 May;103:253-260.
23	Transcriptome analysis of airborne PM2.5-induced detrimental effects on human keratinocytes. Toxicol Lett. 2017 May 5;273:26-35.
24	Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures. Food Chem Toxicol. 2019 Mar;125:252-270.
25	Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
26	An adverse outcome pathway-based approach to assess steatotic mixture effects of hepatotoxic pesticides in vitro. Food Chem Toxicol. 2020 May;139:111283.
27	Acrylamide exposure represses neuronal differentiation, induces cell apoptosis and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids. Food Chem Toxicol. 2020 Oct;144:111643.
28	Dynamic alteration in miRNA and mRNA expression profiles at different stages of chronic arsenic exposure-induced carcinogenesis in a human cell culture model of skin cancer. Arch Toxicol. 2021 Jul;95(7):2351-2365.
29	The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1226). Nucleic Acids Res. 2015 Oct 12. pii: gkv1037.
30	Identification and characterization of 3-iodothyronamine intracellular transport. Endocrinology. 2009 Apr;150(4):1991-9.
31	Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
32	Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line. Genomics. 2009;93(4):332-42.
33	Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
34	Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
35	Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells. Toxicol Sci. 2025;203(2):216-226.
36	Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet. 2015;24(5):1374-89.
37	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
38	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
39	DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
40	Evaluation of Cd-induced cytotoxicity in primary human keratinocytes. Hum Exp Toxicol. 2024;43:9603271231224458.
41	Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022;449:116110.
42	Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array. BMC Genomics. 2009;10:126.
43	High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
44	Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
45	Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro. Environ Toxicol Pharmacol. 2012;34(3):959-68.
46	Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells. Respir Res. 2018 Aug 30;19(1):160.
47	Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023;15(2).
48	Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
49	Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006;118(7):1699-712.
50	Transcriptional Modulation of the ERK1/2 MAPK and NF-B Pathways in Human Urothelial Cells After Trivalent Arsenical Exposure: Implications for Urinary Bladder Cancer. J Can Res Updates. 2012;1:57-68.
51	Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics. 2012 Aug;4(8):784-93.
52	A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
53	Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization. J Am Coll Cardiol. 2015;66(18):2005-2015.
54	Perfluoroalkyl substances (PFASs) decrease the expression of recombination-activating genes (RAG1 and RAG2) in human B lymphoma Namalwa cells. Arch Toxicol. 2022;97(2):457-68.
55	One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.
56	High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
57	Cell cycle pathway dysregulation in human keratinocytes during chronic exposure to low arsenite. Toxicol Appl Pharmacol. 2017 Sep 15;331:130-134.
58	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
59	Endothelial effects of emission source particles: acute toxic response gene expression profiles. Toxicol In Vitro. 2009 Feb;23(1):67-77.
60	Withaferin A mitigates metastatic traits in human oral squamous cell carcinoma caused by aberrant claudin-1 expression. Cell Biol Toxicol. 2022;38(1):147-165.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Exogenous Modulation

Visitor Map

Correspondence