Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0471 Transporter Info
Gene Name	SLC7A5
Transporter Name	L-type amino acid transporter 1
Gene ID	8140
UniProt ID	Q01650

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Ethinyl Estradiol affects the expression of SLC7A5 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC7A5 mRNA			[93]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol results in increased expression of SLC7A5 mRNA			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin results in decreased expression of SLC7A5 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cyclosporine results in increased expression of SLC7A5 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cisplatin affects the expression of SLC7A5 mRNA			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cisplatin results in increased expression of SLC7A5 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tretinoin results in increased expression of SLC7A5 mRNA			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid results in increased methylation of SLC7A5 gene			[125]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of SLC7A5 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Coumestrol co-treated with Resveratrol results in increased expression of SLC7A5 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ESR1 promotes the reaction Genistein results in increased expression of SLC7A5 protein			[98]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC7A5 promoter			[81]
Regulation Mechanism				Transcription Factor Info
1-Butanol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC7A5 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
1-Methyl-3-isobutylxanthine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin results in decreased expression of SLC7A5 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
1-Methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium results in increased expression of SLC7A5 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
2,3-bis(3'-hydroxybenzyl)butyrolactone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of SLC7A5 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
3,4,5,3',4'-pentachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLC7A5 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC7A5 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of SLC7A5 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of SLC7A5 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC7A5 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC7A5 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of SLC7A5 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC7A5 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
Acetylglucosamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylglucosamine results in decreased expression of SLC7A5 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afimoxifene results in increased expression of SLC7A5 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
allyl 2,4,6-tribromophenyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	allyl 2,4,6-tribromophenyl ether results in increased expression of SLC7A5 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
AM 251	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AM 251 results in increased expression of SLC7A5 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC7A5 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite affects the expression of SLC7A5 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azoxystrobin affects the expression of SLC7A5 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
benz(a)anthracene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benz(a)anthracene results in increased expression of SLC7A5 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
beta-methylcholine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-methylcholine affects the expression of SLC7A5 mRNA			[82]
Regulation Mechanism				Transcription Factor Info
beta-Naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-Naphthoflavone results in increased expression of SLC7A5 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
bisphenol A	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC7A5 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A analog results in increased expression of SLC7A5 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in decreased expression of SLC7A5 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	bisphenol A results in increased expression of SLC7A5 mRNA			[84]
Regulation Mechanism				Transcription Factor Info
bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol B results in increased expression of SLC7A5 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F results in increased expression of SLC7A5 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
bisphenol S	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S affects the expression of SLC7A5 protein			[85]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol S results in increased expression of SLC7A5 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
bisphenol Z	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol Z results in increased expression of SLC7A5 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC7A5 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased expression of SLC7A5 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
Cannabidiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cannabidiol results in decreased expression of SLC7A5 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
chloroacetaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chloroacetaldehyde affects the expression of SLC7A5 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chloropicrin results in decreased expression of SLC7A5 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
chromium hexavalent ion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in decreased expression of SLC7A5 mRNA			[88]
Regulation Mechanism				Transcription Factor Info
chrysene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chrysene results in increased expression of SLC7A5 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC7A5 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
Colforsin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colforsin results in increased expression of SLC7A5 mRNA			[90]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Colforsin results in increased expression of SLC7A5 protein			[90]
Regulation Mechanism				Transcription Factor Info
Cycloheximide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin co-treated with Cycloheximide results in increased expression of SLC7A5 mRNA			[91]
Regulation Mechanism				Transcription Factor Info
Dactinomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dactinomycin inhibits the reaction Vehicle Emissions results in increased expression of SLC7A5 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein results in increased expression of SLC7A5 mRNA			[3]
Regulation Mechanism				Transcription Factor Info
deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	deguelin results in increased expression of SLC7A5 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in increased expression of SLC7A5 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of SLC7A5 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
eprenetapopt	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	eprenetapopt results in increased expression of SLC7A5 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	TP53 protein affects the reaction eprenetapopt results in increased expression of SLC7A5 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
Ethanol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with Ethanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC7A5 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
Etoposide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC7A5 protein affects the susceptibility to Etoposide			[94]
Regulation Mechanism				Transcription Factor Info
fenpyroximate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	fenpyroximate results in increased expression of SLC7A5 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FR900359 results in decreased phosphorylation of SLC7A5 protein			[95]
Regulation Mechanism				Transcription Factor Info
Furaldehyde	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC7A5 protein			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with Furaldehyde results in increased expression of SLC7A5 protein			[96]
Regulation Mechanism				Transcription Factor Info
Gabapentin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC7A5 protein results in increased import of Gabapentin			[97]
Regulation Mechanism				Transcription Factor Info
Gasoline	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC7A5 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Gasoline co-treated with Ethanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC7A5 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Gasoline results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC7A5 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in increased expression of SLC7A5 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
indeno(1,2,3-cd)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	indeno(1,2,3-cd)pyrene results in increased expression of SLC7A5 mRNA			[99]
Regulation Mechanism				Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin results in decreased expression of SLC7A5 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	K 7174 results in decreased expression of SLC7A5 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A5 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A5 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in increased expression of SLC7A5 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
Mestranol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mestranol results in increased expression of SLC7A5 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in increased expression of SLC7A5 mRNA			[101]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in decreased expression of SLC7A5 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
Mitoxantrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC7A5 protein affects the susceptibility to Mitoxantrone			[94]
Regulation Mechanism				Transcription Factor Info
nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nickel chloride results in increased expression of SLC7A5 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
nickel sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nickel sulfate results in increased expression of SLC7A5 mRNA			[103]
Regulation Mechanism				Transcription Factor Info
Nicotine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine results in increased expression of SLC7A5 mRNA			[14]
Regulation Mechanism				Transcription Factor Info
NSC668394	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC668394 results in increased expression of SLC7A5 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC7A5 mRNA			[104]
Regulation Mechanism				Transcription Factor Info
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PON1 gene polymorphism affects the susceptibility to O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of SLC7A5 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
o,p'-DDT	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	o,p'-DDT results in increased expression of SLC7A5 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
Oxazolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxazolone results in increased expression of SLC7A5 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
Oxygen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of SLC7A5 mRNA			[107]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Oxygen deficiency results in increased expression of SLC7A5 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in increased expression of SLC7A5 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in increased expression of SLC7A5 mRNA			[109]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens results in decreased expression of SLC7A5 mRNA			[110]
Regulation Mechanism				Transcription Factor Info
Phytoestrogens	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens results in decreased expression of SLC7A5 mRNA			[110]
Regulation Mechanism				Transcription Factor Info
picoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	picoxystrobin results in increased expression of SLC7A5 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pirinixic acid binds to and results in increased activity of PPARA protein which results in increased expression of SLC7A5 mRNA			[111]
Regulation Mechanism				Transcription Factor Info
potassium bromate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	potassium bromate results in increased expression of SLC7A5 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
pyrachlostrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrachlostrobin results in increased expression of SLC7A5 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
pyrimidifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrimidifen results in increased expression of SLC7A5 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
pyrogallol 1,3-dimethyl ether	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of SLC7A5 protein			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC7A5 protein			[96]
Regulation Mechanism				Transcription Factor Info
quinocetone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quinocetone results in decreased expression of SLC7A5 mRNA			[112]
Regulation Mechanism				Transcription Factor Info
Roscovitine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Roscovitine inhibits the reaction Vehicle Emissions results in increased expression of SLC7A5 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
rutecarpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rutecarpine results in increased expression of SLC7A5 mRNA			[113]
Regulation Mechanism				Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine results in increased expression of SLC7A5 mRNA			[114]
Regulation Mechanism				Transcription Factor Info
Selenium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selenium results in increased expression of SLC7A5 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of SLC7A5 mRNA			[115]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC7A5 mRNA			[116]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A5 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in increased expression of SLC7A5 mRNA			[117]
Regulation Mechanism				Transcription Factor Info
Sodium Chloride	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC7A5 protein			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with Furaldehyde results in increased expression of SLC7A5 protein			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of SLC7A5 protein			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC7A5 protein			[96]
Regulation Mechanism				Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite results in increased expression of SLC7A5 mRNA			[118]
Regulation Mechanism				Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide results in decreased expression of SLC7A5 mRNA			[2]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin affects the expression of SLC7A5 mRNA			[119]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin co-treated with AHR mRNA affects the expression of SLC7A5 mRNA			[120]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin co-treated with Cycloheximide results in increased expression of SLC7A5 mRNA			[91]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Tetrachlorodibenzodioxin results in increased expression of SLC7A5 mRNA			[121]
Regulation Mechanism				Transcription Factor Info
thifluzamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	thifluzamide results in increased expression of SLC7A5 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC7A5 mRNA			[116]
Regulation Mechanism				Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A5 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of SLC7A5 mRNA			[123]
Regulation Mechanism				Transcription Factor Info
tri-o-cresyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tri-o-cresyl phosphate results in increased expression of SLC7A5 mRNA			[124]
Regulation Mechanism				Transcription Factor Info
Tryptophan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tryptophan results in increased expression of SLC7A5 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
zinc chromate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in decreased expression of SLC7A5 mRNA			[88]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of SLC7A5 mRNA			[108]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Arginine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arginine inhibits the transportation of Gabapentin by SLC7A5			[1]
Affected Drug/Substrate	Gabapentin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-LAT1
L-tyrosine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-tyrosine inhibits the transportation of Gabapentin by SLC7A5			[1]
Affected Drug/Substrate	Gabapentin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-LAT1
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide inhibits the expression of SLC7A5			[2]
Bexarotene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bexarotene inhibits the expression of SLC7A5			[4]
Oxaliplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxaliplatin inhibits the expression of SLC7A5			[5]
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the expression of SLC7A5			[6]
Ethinyl Estradiol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol increases the expression of SLC7A5			[7]
Tamoxifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen inhibits the expression of SLC7A5			[8]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of SLC7A5			[9]
Isotretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isotretinoin inhibits the expression of SLC7A5			[10]
Bortezomib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bortezomib inhibits the expression of SLC7A5			[11]
Piroxicam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the expression of SLC7A5			[12]
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine affects the expression of SLC7A5			[13]
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine polacrilex increases the expression of SLC7A5			[14]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC7A5			[15]
Dexamethasone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone inhibits the expression of SLC7A5			[16]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC7A5			[17]
Cidofovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cidofovir increases the expression of SLC7A5			[18]
Fenofibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenofibrate increases the expression of SLC7A5			[18]
Ibuprofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen increases the expression of SLC7A5			[18]
Ifosfamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ifosfamide increases the expression of SLC7A5			[18]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of SLC7A5			[19]
Panobinostat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Panobinostat increases the expression of SLC7A5			[20]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC7A5			[21]
DT Modulation2	Acetaminophen results in increased expression of SLC7A5 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
Estrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estrone increases the expression of SLC7A5			[22]
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fulvestrant inhibits the expression of SLC7A5			[22]
Raloxifene Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride inhibits the expression of SLC7A5			[22]
Cisplatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of SLC7A5			[23]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC7A5			[24]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC7A5			[25]
Isoniazid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isoniazid inhibits the expression of SLC7A5			[26]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC7A5			[27]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Temozolomide increases the expression of SLC7A5			[28]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC7A5			[29]
Tretinoin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC7A5			[31]
Diethylstilbestrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylstilbestrol increases the expression of SLC7A5			[22]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC7A5			[26]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of SLC7A5			[18]
Drug Marketed but not Approved by US FDA
Daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daidzein increases the expression of SLC7A5			[3]
Clodronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clodronic Acid affects the expression of SLC7A5			[18]
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rotenone increases the expression of SLC7A5			[30]
Drug in Phase 3 Trial
Fenretinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenretinide increases the expression of SLC7A5			[33]
Afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Afimoxifene increases the expression of SLC7A5			[40]
Drug in Phase 2 Trial
MS-275	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of SLC7A5			[20]
Bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol B increases the expression of SLC7A5			[55]
Genistein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLC7A5			[22]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC7A5			[61]
Drug in Phase 1 Trial
Dinitrochlorobenzene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dinitrochlorobenzene increases the expression of SLC7A5			[36]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin increases the expression of SLC7A5			[41]
L-tryptophan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-tryptophan increases the expression of SLC7A5			[57]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC7A5			[59]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC7A5			[20]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC7A5			[43]
Investigative Drug
L-leucine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-leucine inhibits the transportation of Gabapentin by SLC7A5			[1]
Affected Drug/Substrate	Gabapentin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-LAT1
L-phenylalanine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-phenylalanine inhibits the transportation of Gabapentin by SLC7A5			[1]
Affected Drug/Substrate	Gabapentin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-LAT1
Coumestrol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol increases the expression of SLC7A5			[37]
Beta-naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beta-naphthoflavone increases the expression of SLC7A5			[39]
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of SLC7A5			[20]
Patented Pharmaceutical Agent
AM-251	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AM-251 increases the expression of SLC7A5			[34]
K-7174	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	K-7174 inhibits the expression of SLC7A5			[45]
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG-001 increases the expression of SLC7A5			[48]
NSC-668394	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC-668394 increases the expression of SLC7A5			[51]
Natural Product
Selenium nanoparticles	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selenium nanoparticles increases the expression of SLC7A5			[38]
Thapsigargin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thapsigargin increases the expression of SLC7A5			[42]
Cholesterol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cholesterol increases the expression of SLC7A5			[49]
Deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deguelin increases the expression of SLC7A5			[30]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC7A5			[60]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of SLC7A5			[62]
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with Resveratrol results in increased expression of SLC7A5 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of SLC7A5			[32]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Human breast cancer cells (MDA-MB-231); human breast cancer cells (MDA-MB-231)
2,3-dibromopropyl-2,4,6-tribromophenyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,3-dibromopropyl-2,4,6-tribromophenyl ether increases the expression of SLC7A5			[47]
Bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol F increases the expression of SLC7A5			[58]
Mercury	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC7A5 gene SNP affects the susceptibility to and affects the abundance of Mercury			[100]
Regulation Mechanism				Transcription Factor Info
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC7A5			[54]
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLC7A5 intron			[74]
Regulation Mechanism				Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in decreased methylation of SLC7A5 intron			[74]
Regulation Mechanism				Transcription Factor Info
ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ochratoxin A results in increased expression of SLC7A5 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in increased expression of SLC7A5 mRNA			[126]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel chloride increases the expression of SLC7A5			[35]
Chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloropicrin inhibits the expression of SLC7A5			[50]
Ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ochratoxin A increases the expression of SLC7A5			[26]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrylamide increases the expression of SLC7A5			[56]
Antimycin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Antimycin A increases the expression of SLC7A5			[30]
Carcinogen
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate inhibits the expression of SLC7A5			[44]
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC7A5			[54]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC7A5 gene			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A5 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
Benzene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzene results in increased expression of SLC7A5 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel results in increased expression of SLC7A5 mRNA			[102]
Regulation Mechanism				Transcription Factor Info
Fungicide
Azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azoxystrobin affects the expression of SLC7A5			[30]
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dicrotophos increases the expression of SLC7A5			[52]
Health and Environmental Toxicant
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium increases the expression of SLC7A5			[46]
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate increases the expression of SLC7A5			[53]
Herbicide
Atrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atrazine inhibits the expression of SLC7A5			[42]

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120	Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes. Toxicol In Vitro. 2010;24(6):1775-81.
121	Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression. Toxicol Lett. 2001 Jul 6;122(3):189-203.
122	Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
123	From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
124	Organophosphate ester tri-o-cresyl phosphate interacts with estrogen receptor in MCF-7 breast cancer cells promoting cancer growth. Toxicol Appl Pharmacol. 2020;395:114977.
125	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
126	Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.

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