Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0464 Transporter Info
Gene Name	SLC7A11
Transporter Name	Cystine/glutamate transporter
Gene ID	23657
UniProt ID	Q9UPY5

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Approved Drug
Ibuprofen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ibuprofen inhibits the expression of SLC7A11		[1]
Regulation Mechanism	via the inhibition of Nuclear factor erythroid 2-related factor 2 (NFE2L2)		Transcription Factor Info
Cell System	Human glioblastoma cells
Flutamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Flutamide inhibits the expression of SLC7A11		[2]
Regulation Mechanism	via the inhibition of Androgen receptor (AR)		Transcription Factor Info
Cell System	Sprague-Dawley pregnant rats
Aspirin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aspirin inhibits the expression of SLC7A11		[3]
Regulation Mechanism	via the inhibition of Transcription factor p65 (RELA)		Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Entacapone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Entacapone increases the expression of SLC7A11		[4]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)		Transcription Factor Info
Cell System	C57BL/6 mice
Estrone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estrone increases the expression of SLC7A11		[5]
Bicalutamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bicalutamide increases the expression of SLC7A11		[6]
Zinc Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc Acetate increases the expression of SLC7A11		[7]
Raloxifene Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride increases the expression of SLC7A11		[8]
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Indomethacin increases the expression of SLC7A11		[9]
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Progesterone increases the expression of SLC7A11		[10]
Hydrogen Peroxide	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide inhibits the expression of SLC7A11		[11]
Phenobarbital	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenobarbital increases the expression of SLC7A11		[12]
Azathioprine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Azathioprine inhibits the expression of SLC7A11		[13]
Methotrexate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the expression of SLC7A11		[13]
Methylprednisolone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methylprednisolone inhibits the expression of SLC7A11		[13]
Piroxicam	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the expression of SLC7A11		[13]
Prednisolone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Prednisolone inhibits the expression of SLC7A11		[13]
Sulfasalazine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sulfasalazine inhibits the activity of SLC7A11		[14]
Ethinyl Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol affects the expression of SLC7A11		[15]
Copper Sulfate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC7A11		[16]
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vincristine increases the expression of SLC7A11		[17]
Cyclophosphamide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclophosphamide inhibits the expression of SLC7A11		[18]
Fluoxetine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fluoxetine increases the expression of SLC7A11		[18]
Mycophenolic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mycophenolic Acid inhibits the expression of SLC7A11		[18]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of SLC7A11		[19]
Diethylstilbestrol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diethylstilbestrol inhibits the expression of SLC7A11		[20]
Mitomycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mitomycin inhibits the expression of SLC7A11		[20]
Vitamin C	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin C increases the expression of SLC7A11		[20]
Panobinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Panobinostat increases the expression of SLC7A11		[21]
Belinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Belinostat inhibits the expression of SLC7A11		[22]
Arsenic	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic increases the expression of SLC7A11		[23]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane increases the expression of SLC7A11		[24]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC7A11		[25]
Doxorubicin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC7A11		[26]
Hydroquinone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydroquinone increases the expression of SLC7A11		[27]
Cannabidiol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cannabidiol increases the expression of SLC7A11		[28]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC7A11		[29]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Temozolomide increases the expression of SLC7A11		[30]
Acyclovir	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acyclovir increases the expression of SLC7A11		[31]
Amikacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Amikacin inhibits the expression of SLC7A11		[31]
Aminosalicylic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aminosalicylic acid increases the expression of SLC7A11		[31]
Biperiden	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Biperiden increases the expression of SLC7A11		[31]
Bromfenac	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bromfenac inhibits the expression of SLC7A11		[31]
Diphenhydramine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diphenhydramine inhibits the expression of SLC7A11		[31]
Ethambutol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethambutol increases the expression of SLC7A11		[31]
Fexofenadine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fexofenadine inhibits the expression of SLC7A11		[31]
Fludrocortisone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fludrocortisone inhibits the expression of SLC7A11		[31]
Isoproterenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isoproterenol increases the expression of SLC7A11		[31]
Ketoconazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ketoconazole increases the expression of SLC7A11		[31]
Levofloxacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Levofloxacin increases the expression of SLC7A11		[31]
Liothyronine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Liothyronine increases the expression of SLC7A11		[31]
Mebendazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mebendazole increases the expression of SLC7A11		[31]
Oseltamivir	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oseltamivir inhibits the expression of SLC7A11		[31]
Penbutolol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Penbutolol increases the expression of SLC7A11		[31]
Pioglitazone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pioglitazone increases the expression of SLC7A11		[31]
Protriptyline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Protriptyline inhibits the expression of SLC7A11		[31]
Tolcapone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tolcapone inhibits the expression of SLC7A11		[31]
Trazodone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trazodone increases the expression of SLC7A11		[31]
Trihexyphenidyl	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trihexyphenidyl increases the expression of SLC7A11		[31]
Troglitazone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Troglitazone increases the expression of SLC7A11		[31]
Valproic Acid	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC7A11		[31]
Zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zafirlukast inhibits the expression of SLC7A11		[31]
Celecoxib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Celecoxib increases the expression of SLC7A11		[32]
Amiodarone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Amiodarone increases the expression of SLC7A11		[33]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Menadione increases the expression of SLC7A11		[34]
Estradiol	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of SLC7A11		[35]
Arsenic Trioxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC7A11		[36]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of SLC7A11		[37]
Diclofenac	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the expression of SLC7A11		[32]
Acetaminophen	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of SLC7A11		[38]
DT Modulation2	Acetaminophen affects the expression of SLC7A11 mRNA		[109]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of SLC7A11 mRNA		[110]
Regulation Mechanism			Transcription Factor Info
Ampicillin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ampicillin inhibits the expression of SLC7A11		[20]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC7A11		[39]
Lindane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lindane increases the expression of SLC7A11		[20]
Cisplatin	17 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of SLC7A11		[32]
Vorinostat	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vorinostat inhibits the activity of SLC7A11		[40]
Drug Marketed but not Approved by US FDA
Estriol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estriol increases the expression of SLC7A11		[5]
Demecolcine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Demecolcine increases the expression of SLC7A11		[17]
Lumiracoxib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lumiracoxib increases the expression of SLC7A11		[31]
Drug in Phase 2/3 Trial
Phenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenol increases the expression of SLC7A11		[20]
Drug in Phase 3 Trial
Tetrathiomolybdate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrathiomolybdate increases the expression of SLC7A11		[41]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)		Transcription Factor Info
Cell System	Human umbilical vein endothelial cells (CRL-1730)
Curcumin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Curcumin increases the expression of SLC7A11		[48]
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sulforafan increases the expression of SLC7A11		[87]
Drug in Phase 2 Trial
Motexafin gadolinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Motexafin gadolinium increases the expression of SLC7A11		[7]
Genistein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Genistein inhibits the expression of SLC7A11		[42]
STA-4783	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	STA-4783 increases the expression of SLC7A11		[49]
Trichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichloroethylene increases the expression of SLC7A11		[50]
MeIQx	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MeIQx increases the expression of SLC7A11		[51]
MS-275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of SLC7A11		[21]
Bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol B increases the expression of SLC7A11		[69]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC7A11		[76]
Drug in Phase 1 Trial
Gold Sodium Thiomalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gold Sodium Thiomalate inhibits the expression of SLC7A11		[13]
Racecadotril	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Racecadotril increases the expression of SLC7A11		[59]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC7A11		[71]
Tetradecanoylphorbol Acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetradecanoylphorbol Acetate increases the expression of SLC7A11		[20]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin increases the expression of SLC7A11		[20]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC7A11		[21]
Drug in Preclinical Test
Tripterine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tripterine increases the expression of SLC7A11		[44]
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC7A11		[81]
Investigative Drug
Arachidonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arachidonic acid increases the expression of SLC7A11		[43]
Coumestrol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol inhibits the expression of SLC7A11		[35]
Mono-(2-ethylhexyl)phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mono-(2-ethylhexyl)phthalate increases the expression of SLC7A11		[18]
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of SLC7A11		[21]
Farnesol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Farnesol increases the expression of SLC7A11		[65]
Patulin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Patulin increases the expression of SLC7A11		[74]
Patented Pharmaceutical Agent
Vanillin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vanillin increases the expression of SLC7A11		[45]
K-7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K-7174 increases the expression of SLC7A11		[56]
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG-001 increases the expression of SLC7A11		[61]
NSC-668394	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC-668394 increases the expression of SLC7A11		[62]
Erastin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Erastin inhibits the expression of SLC7A11		[73]
Eugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Eugenol increases the expression of SLC7A11		[65]
Drug Withdrawn
Ticrynafen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ticrynafen increases the expression of SLC7A11		[31]
Natural Product
Gedunin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gedunin increases the expression of SLC7A11		[44]
DT Modulation1	Curcumin inhibits the reaction Firemaster BP-6 results in decreased expression of SLC7A11 protein		[148]
Regulation Mechanism			Transcription Factor Info
Bilirubin	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bilirubin increases the expression of SLC7A11		[54]
Thapsigargin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thapsigargin increases the expression of SLC7A11		[64]
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyleugenol increases the expression of SLC7A11		[68]
Shogaol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Shogaol inhibits the expression of SLC7A11		[75]
Cinnamic aldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cinnamic aldehyde increases the expression of SLC7A11		[65]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of SLC7A11		[79]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC7A11		[80]
Resveratrol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Resveratrol inhibits the reaction deoxynivalenol results in decreased expression of SLC7A11 protein		[154]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Resveratrol results in increased expression of SLC7A11 mRNA		[154]
Regulation Mechanism			Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC7A11		[53]
Resorcinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Resorcinol inhibits the expression of SLC7A11		[20]
Diazinon	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diazinon increases the expression of SLC7A11		[20]
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A increases the expression of SLC7A11		[84]
Lead	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lead results in increased expression of SLC7A11 mRNA		[176]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLC7A11		[53]
DT Modulation2	Aflatoxin B1 affects the expression of SLC7A11 protein		[112]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in decreased methylation of SLC7A11 gene		[113]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Aflatoxin B1 results in increased expression of SLC7A11 mRNA		[114]
Regulation Mechanism			Transcription Factor Info
Deoxynivalenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Deoxynivalenol inhibits the expression of SLC7A11		[67]
DT Modulation1	Patulin promotes the reaction BECN1 protein modified form binds to SLC7A11 protein		[74]
Regulation Mechanism			Transcription Factor Info
ochratoxin A	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine promotes the reaction ochratoxin A results in decreased expression of SLC7A11 protein		[88]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ferrostatin-1 inhibits the reaction ochratoxin A results in decreased expression of SLC7A11 protein		[88]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ochratoxin A affects the expression of SLC7A11 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	ochratoxin A results in decreased expression of SLC7A11 protein		[88]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	tetrahydro-N, N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride inhibits the reaction ochratoxin A results in decreased expression of SLC7A11 protein		[88]
Regulation Mechanism			Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in increased expression of SLC7A11 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel chloride increases the expression of SLC7A11		[47]
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Formaldehyde increases the expression of SLC7A11		[17]
Ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ochratoxin A affects the expression of SLC7A11		[55]
1,6-hexamethylene diisocyanate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1,6-hexamethylene diisocyanate increases the expression of SLC7A11		[57]
Acrolein	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein increases the expression of SLC7A11		[57]
Chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chloropicrin increases the expression of SLC7A11		[57]
Cadmium	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the expression of SLC7A11		[58]
Chlorpyrifos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos increases the expression of SLC7A11		[59]
2-methyl-4-isothiazolin-3-one	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-methyl-4-isothiazolin-3-one increases the expression of SLC7A11		[65]
Paraquat	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paraquat increases the expression of SLC7A11		[72]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide increases the expression of SLC7A11		[82]
Enniatins	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Enniatins increases the expression of SLC7A11		[86]
Carcinogen
DT Modulation1	Arsenic affects the methylation of SLC7A11 gene		[120]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Arsenic results in decreased expression of SLC7A11 mRNA		[121]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A11 mRNA		[122]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC7A11 mRNA		[122]
Regulation Mechanism			Transcription Factor Info
Polychlorinated Biphenyls	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated Biphenyls inhibits the expression of SLC7A11		[42]
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate increases the expression of SLC7A11		[17]
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC7A11		[18]
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC7A11 mRNA		[133]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium results in increased expression of SLC7A11 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
2-amino-3-methylimidazo(4,5-f)quinoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-amino-3-methylimidazo(4,5-f)quinoline increases the expression of SLC7A11		[20]
Dimethyl nitrosamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dimethyl nitrosamine increases the expression of SLC7A11		[20]
Benzene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzene results in increased expression of SLC7A11 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel results in increased expression of SLC7A11 mRNA		[182]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Cypermethrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cypermethrin increases the expression of SLC7A11		[59]
Coumaphos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumaphos increases the expression of SLC7A11		[20]
DDT	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	DDT results in increased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
Health and Environmental Toxicant
Zymosan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zymosan increases the expression of SLC7A11		[46]
Dichloromethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dichloromethane increases the expression of SLC7A11		[50]
Ethyl benzene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl benzene increases the expression of SLC7A11		[50]
7-aminocephalosporanic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7-aminocephalosporanic acid increases the expression of SLC7A11		[57]
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram increases the expression of SLC7A11		[57]
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of SLC7A11		[60]
Azaspiracid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Azaspiracid increases the expression of SLC7A11		[63]
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate increases the expression of SLC7A11		[66]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid increases the expression of SLC7A11		[70]
Glycidamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycidamide increases the expression of SLC7A11		[77]
Toluene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Toluene increases the expression of SLC7A11		[78]
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium increases the expression of SLC7A11		[83]
Endosulfan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Endosulfan co-treated with Tetrachlorodibenzodioxin results in increased expression of SLC7A11 mRNA		[161]
Regulation Mechanism			Transcription Factor Info
Herbicide
Diquat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diquat increases the expression of SLC7A11		[52]
DT Modulation1	alpha-Tocopherol co-treated with Paraquat results in increased expression of SLC7A11 mRNA		[116]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	alpha-Tocopherol co-treated with Paraquat results in increased expression of SLC7A11 protein		[116]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NFE2L2 protein inhibits the reaction Paraquat results in decreased expression of SLC7A11 protein		[186]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Paraquat results in decreased expression of SLC7A11 protein		[186]
Regulation Mechanism			Transcription Factor Info
Nanoparticle
Silver nanoparticle	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver nanoparticle increases the expression of SLC7A11		[85]
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of SLC7A11 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
Chemical Compound
DT Modulation1	Zinc Acetate co-treated with motexafin gadolinium affects the expression of SLC7A11 mRNA		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione which results in decreased susceptibility to Hydrogen Peroxide		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Hydrogen Peroxide affects the expression of SLC7A11 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Hydrogen Peroxide results in increased expression of SLC7A11 mRNA		[172]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Azathioprine results in increased expression of SLC7A11 mRNA		[125]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Prednisolone results in increased expression of SLC7A11 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Sulfasalazine results in decreased activity of SLC7A11 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Copper Sulfate results in increased expression of SLC7A11 mRNA		[146]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cyclophosphamide affects the expression of SLC7A11 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Diethylstilbestrol results in increased expression of SLC7A11 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	SLC7A11 protein affects the susceptibility to Doxorubicin		[149]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cannabidiol results in decreased expression of SLC7A11 protein		[136]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC7A11 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Valproic Acid results in increased expression of SLC7A11 mRNA		[178]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol affects the expression of SLC7A11 mRNA		[165]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC7A11 mRNA		[166]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Estradiol results in increased expression of SLC7A11 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	SLC7A11 protein results in decreased susceptibility to Arsenic Trioxide		[123]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Diclofenac results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cisplatin results in decreased susceptibility to Cisplatin which results in increased expression of SLC7A11 mRNA		[137]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cisplatin results in increased expression of SLC7A11 mRNA		[138]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cisplatin results in increased sumoylation of SLC7A11 protein		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	gap 27 peptide inhibits the reaction Cisplatin results in decreased expression of SLC7A11 protein		[73]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	GJA1 protein affects the reaction Cisplatin results in decreased expression of SLC7A11 protein		[73]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	MIR375 promotes the reaction Cisplatin results in decreased expression of SLC7A11 mRNA		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	MIR375 promotes the reaction Cisplatin results in decreased expression of SLC7A11 protein		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	PIAS4 protein results in increased sumoylation of SLC7A11 protein which results in decreased susceptibility to Cisplatin		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	Ropivacaine promotes the reaction Cisplatin results in decreased expression of SLC7A11 protein		[140]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	Ropivacaine results in increased susceptibility to Cisplatin which results in decreased expression of SLC7A11 protein		[140]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	SIRT1 protein affects the reaction Ropivacaine results in increased susceptibility to Cisplatin which results in decreased expression of SLC7A11 protein		[140]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	SLC7A11 protein affects the susceptibility to Cisplatin		[141]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	SLC7A11 protein inhibits the reaction Cisplatin results in increased activity of CASP3 protein		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	SLC7A11 protein results in decreased susceptibility to Cisplatin		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	tanshinone II A sodium sulfonate inhibits the reaction PIAS4 protein results in increased sumoylation of SLC7A11 protein which results in decreased susceptibility to Cisplatin		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation16	tanshinone II A sodium sulfonate inhibits the reaction SLC7A11 protein results in decreased susceptibility to Cisplatin		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Vorinostat results in increased expression of SLC7A11 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SLC7A11 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione which results in decreased susceptibility to Hydrogen Peroxide		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC7A11 mRNA		[111]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC7A11 mRNA		[111]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the expression of SLC7A11 mRNA		[112]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased expression of SLC7A11 mRNA		[127]
Regulation Mechanism			Transcription Factor Info
Ethyl acrylate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl acrylate inhibits the expression of SLC7A11		[20]
Para-anisidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Para-anisidine increases the expression of SLC7A11		[20]
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine promotes the reaction ochratoxin A results in decreased expression of SLC7A11 protein		[88]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine results in decreased expression of SLC7A11 protein		[88]
Regulation Mechanism			Transcription Factor Info
1,2-diamino-4-nitrobenzene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1,2-diamino-4-nitrobenzene results in increased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
1,2-dihydroxynaphthalene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 mRNA		[89]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 protein		[89]
Regulation Mechanism			Transcription Factor Info
1,3-dichloro-2-propanol	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein		[90]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Dimethyl Fumarate inhibits the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein		[90]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Thiazoles binds to indoline promotes the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein		[90]
Regulation Mechanism			Transcription Factor Info
1-Methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium results in increased expression of SLC7A11 mRNA		[91]
Regulation Mechanism			Transcription Factor Info
1-nitropyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-nitropyrene results in decreased expression of SLC7A11 protein		[92]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	CYP1B1 protein promotes the reaction 1-nitropyrene results in decreased expression of SLC7A11 protein		[92]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ferrostatin-1 inhibits the reaction 1-nitropyrene results in decreased expression of SLC7A11 protein		[92]
Regulation Mechanism			Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of SLC7A11 mRNA		[93]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC7A11 mRNA		[94]
Regulation Mechanism			Transcription Factor Info
2,3-bis(3'-hydroxybenzyl)butyrolactone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SLC7A11 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SLC7A11 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
2,3-dichloro-1-propanol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,3-dichloro-1-propanol results in increased expression of SLC7A11 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
2,4,5,2',4',5'-hexachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SLC7A11 mRNA		[95]
Regulation Mechanism			Transcription Factor Info
25-hydroxycholesterol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	25-hydroxycholesterol results in decreased expression of SLC7A11 protein		[96]
Regulation Mechanism			Transcription Factor Info
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of SLC7A11 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
2-amino-4-methylphenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC7A11 gene SNP affects the susceptibility to 2-amino-4-methylphenol		[97]
Regulation Mechanism			Transcription Factor Info
2-chloromethylpyridine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-chloromethylpyridine results in increased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
2-Propanol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-Propanol results in increased expression of SLC7A11 mRNA		[98]
Regulation Mechanism			Transcription Factor Info
2-tert-butylhydroquinone	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-tert-butylhydroquinone inhibits the reaction Matrines results in decreased expression of SLC7A11 mRNA		[99]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	2-tert-butylhydroquinone inhibits the reaction Matrines results in decreased expression of SLC7A11 protein		[99]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	2-tert-butylhydroquinone results in increased expression of SLC7A11 mRNA		[99]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	2-tert-butylhydroquinone results in increased expression of SLC7A11 protein		[99]
Regulation Mechanism			Transcription Factor Info
2-xylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-xylene results in increased expression of SLC7A11 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
3,4,3',4'-tetrachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	3,4,3',4'-tetrachlorobiphenyl affects the expression of SLC7A11 mRNA		[100]
Regulation Mechanism			Transcription Factor Info
3,4,5,3',4'-pentachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLC7A11 mRNA		[101]
Regulation Mechanism			Transcription Factor Info
3-methyladenine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	3-methyladenine inhibits the reaction Nanotubes, Carbon results in decreased expression of SLC7A11 protein		[102]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	8 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
4-anisidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-anisidine results in increased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
4-carboxyphenylglycine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-carboxyphenylglycine results in decreased activity of SLC7A11 protein		[14]
Regulation Mechanism			Transcription Factor Info
4-hydroxy-2-nonenal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	BGN mRNA alternative form binds to OTUB1 protein which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein which results in decreased abundance of 4-hydroxy-2-nonenal		[103]
Regulation Mechanism			Transcription Factor Info
4-phenylbutyric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-phenylbutyric acid inhibits the reaction Particulate Matter results in decreased expression of SLC7A11 protein		[104]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SLC7A11 protein		[105]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC7A11 mRNA		[106]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Deferoxamine affects the reaction 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SLC7A11 protein		[105]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	ferrostatin-1 affects the reaction 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SLC7A11 protein		[105]
Regulation Mechanism			Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of SLC7A11 mRNA		[107]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC7A11 mRNA		[108]
Regulation Mechanism			Transcription Factor Info
Acetylcysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction elesclomol results in increased expression of SLC7A11 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
alpha phellandrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	alpha phellandrene results in decreased expression of SLC7A11 mRNA		[115]
Regulation Mechanism			Transcription Factor Info
alpha-pinene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC7A11 mRNA		[111]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC7A11 mRNA		[111]
Regulation Mechanism			Transcription Factor Info
alpha-Tocopherol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	alpha-Tocopherol co-treated with Paraquat results in increased expression of SLC7A11 mRNA		[116]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	alpha-Tocopherol co-treated with Paraquat results in increased expression of SLC7A11 protein		[116]
Regulation Mechanism			Transcription Factor Info
alpidem	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	alpidem results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
aluminum citrate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aluminum citrate results in decreased expression of SLC7A11 mRNA		[117]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	aluminum citrate results in decreased expression of SLC7A11 protein		[117]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	SLC7A11 protein results in increased uptake of aluminum citrate		[117]
Regulation Mechanism			Transcription Factor Info
Aminosalicylic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aminosalicylic Acid results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
ammonium hexachloroplatinate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ammonium hexachloroplatinate results in increased expression of SLC7A11 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
Amoxicillin-Potassium Clavulanate Combination	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Amoxicillin-Potassium Clavulanate Combination results in increased expression of SLC7A11 mRNA		[87]
Regulation Mechanism			Transcription Factor Info
Arachidonic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arachidonic Acid results in increased expression of SLC7A11 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
arenobufagin	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	AEBP1 protein inhibits the reaction MIR149 mRNA promotes the reaction arenobufagin results in decreased expression of SLC7A11 protein		[118]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	arenobufagin results in decreased expression of SLC7A11 protein		[118]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	MIR149 mRNA promotes the reaction arenobufagin results in decreased expression of SLC7A11 protein		[118]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC7A11 mRNA		[119]
Regulation Mechanism			Transcription Factor Info
Arsenicals	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenicals results in increased expression of SLC7A11 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite affects the expression of SLC7A11 mRNA		[124]
Regulation Mechanism			Transcription Factor Info
Ascorbic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ascorbic Acid results in increased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
azaspiracid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	azaspiracid results in increased expression of SLC7A11 mRNA		[63]
Regulation Mechanism			Transcription Factor Info
baicalein	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	baicalein inhibits the reaction Polymyxin B results in decreased expression of SLC7A11 protein		[126]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SIRT1 protein promotes the reaction baicalein inhibits the reaction Polymyxin B results in decreased expression of SLC7A11 protein		[126]
Regulation Mechanism			Transcription Factor Info
belinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	belinostat results in decreased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Benzethonium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzethonium results in increased expression of SLC7A11 mRNA		[98]
Regulation Mechanism			Transcription Factor Info
benzidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzidine results in increased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
beryllium sulfate	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beryllium sulfate results in decreased expression of SLC7A11 mRNA		[128]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Deferoxamine inhibits the reaction beryllium sulfate results in decreased expression of SLC7A11 mRNA		[128]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NCOA4 protein affects the reaction beryllium sulfate results in decreased expression of SLC7A11 mRNA		[128]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium bisulfide results in increased abundance of Hydrogen Sulfide inhibits the reaction beryllium sulfate results in decreased expression of SLC7A11 mRNA		[128]
Regulation Mechanism			Transcription Factor Info
beta-lapachone	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-lapachone results in decreased expression of SLC7A11 protein		[129]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	beta-lapachone results in increased expression of SLC7A11 mRNA		[129]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ferrostatin-1 inhibits the reaction beta-lapachone results in decreased expression of SLC7A11 protein		[129]
Regulation Mechanism			Transcription Factor Info
bicalutamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bicalutamide results in increased expression of SLC7A11 mRNA		[6]
Regulation Mechanism			Transcription Factor Info
bisphenol A	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC7A11 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A analog results in increased expression of SLC7A11 mRNA		[69]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	bisphenol A results in decreased expression of SLC7A11 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	bisphenol A results in decreased expression of SLC7A11 protein		[130]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	bisphenol A results in increased expression of SLC7A11 mRNA		[131]
Regulation Mechanism			Transcription Factor Info
bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol B results in increased expression of SLC7A11 mRNA		[69]
Regulation Mechanism			Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in increased methylation of SLC7A11 gene		[132]
Regulation Mechanism			Transcription Factor Info
bisphenol Z	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol Z results in increased expression of SLC7A11 mRNA		[69]
Regulation Mechanism			Transcription Factor Info
bis(tri-n-butyltin)oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bis(tri-n-butyltin)oxide results in decreased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
bromfenac	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bromfenac results in decreased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in decreased expression of SLC7A11 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC7A11 mRNA		[134]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC7A11 mRNA		[133]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased expression of SLC7A11 mRNA		[135]
Regulation Mechanism			Transcription Factor Info
captax	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	captax results in increased expression of SLC7A11 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
carbetapentane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	carbetapentane results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
celastrol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	celastrol results in increased expression of SLC7A11 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC7A11 protein results in decreased susceptibility to celastrol		[14]
Regulation Mechanism			Transcription Factor Info
Cetylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cetylpyridinium results in increased expression of SLC7A11 mRNA		[98]
Regulation Mechanism			Transcription Factor Info
Chenodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of SLC7A11 mRNA		[110]
Regulation Mechanism			Transcription Factor Info
chlorantranilipole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chlorantranilipole results in increased expression of SLC7A11 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
chloroacetaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chloroacetaldehyde results in increased expression of SLC7A11 mRNA		[135]
Regulation Mechanism			Transcription Factor Info
chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chloropicrin results in increased expression of SLC7A11 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
Chloroquine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chloroquine inhibits the reaction Particulate Matter results in decreased expression of SLC7A11 protein		[104]
Regulation Mechanism			Transcription Factor Info
chloroquine diphosphate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chloroquine diphosphate results in decreased expression of SLC7A11 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	chloroquine diphosphate results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
cinnamaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cinnamaldehyde results in increased expression of SLC7A11 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Clavulanic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Clavulanic Acid results in decreased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Clavulanic Acid results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased abundance of Oxygen which results in increased expression of SLC7A11 mRNA		[142]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	cobaltous chloride results in decreased abundance of Oxygen which results in increased expression of SLC7A11 protein		[142]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	cobaltous chloride results in increased expression of SLC7A11 mRNA		[143]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	KDM4A protein affects the reaction cobaltous chloride results in decreased abundance of Oxygen which results in increased expression of SLC7A11 mRNA		[142]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	KDM4A protein affects the reaction cobaltous chloride results in decreased abundance of Oxygen which results in increased expression of SLC7A11 protein		[142]
Regulation Mechanism			Transcription Factor Info
Copper	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chelating Agents binds to Copper which results in increased expression of SLC7A11 mRNA		[144]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NSC 689534 binds to Copper which results in increased expression of SLC7A11 mRNA		[145]
Regulation Mechanism			Transcription Factor Info
corosolic acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	corosolic acid results in increased expression of SLC7A11 mRNA		[147]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	corosolic acid results in increased expression of SLC7A11 protein		[147]
Regulation Mechanism			Transcription Factor Info
cresidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cresidine results in decreased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric chloride results in increased expression of SLC7A11 mRNA		[95]
Regulation Mechanism			Transcription Factor Info
cypermethrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cypermethrin results in increased expression of SLC7A11 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
Cystine	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione which results in decreased susceptibility to Hydrogen Peroxide		[54]
Regulation Mechanism			Transcription Factor Info
Dactinomycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dactinomycin results in decreased expression of SLC7A11 protein		[149]
Regulation Mechanism			Transcription Factor Info
Deferoxamine	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Deferoxamine affects the reaction 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SLC7A11 protein		[105]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Deferoxamine inhibits the reaction beryllium sulfate results in decreased expression of SLC7A11 mRNA		[128]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Deferoxamine inhibits the reaction Firemaster BP-6 results in decreased expression of SLC7A11 protein		[148]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Deferoxamine results in decreased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Dehydroepiandrosterone	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dehydroepiandrosterone results in decreased expression of SLC7A11 mRNA		[150]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Dehydroepiandrosterone results in decreased expression of SLC7A11 protein		[150]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	nuciferine inhibits the reaction Dehydroepiandrosterone results in decreased expression of SLC7A11 mRNA		[150]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	nuciferine inhibits the reaction Dehydroepiandrosterone results in decreased expression of SLC7A11 protein		[150]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	SOX2 protein promotes the reaction nuciferine inhibits the reaction Dehydroepiandrosterone results in decreased expression of SLC7A11 protein		[150]
Regulation Mechanism			Transcription Factor Info
Deoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of SLC7A11 mRNA		[110]
Regulation Mechanism			Transcription Factor Info
Deoxyglucose	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Deoxyglucose results in decreased expression of SLC7A11 protein		[151]
Regulation Mechanism			Transcription Factor Info
deoxynivalenol	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	deoxynivalenol results in decreased expression of SLC7A11 mRNA		[67]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	deoxynivalenol results in decreased expression of SLC7A11 protein		[152]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NNMT protein promotes the reaction deoxynivalenol results in decreased expression of SLC7A11 protein		[153]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Resveratrol inhibits the reaction deoxynivalenol results in decreased expression of SLC7A11 protein		[154]
Regulation Mechanism			Transcription Factor Info
dibutyldichlorotin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dibutyldichlorotin results in increased expression of SLC7A11 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Dichlorodiphenyl Dichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene results in decreased expression of SLC7A11 mRNA		[95]
Regulation Mechanism			Transcription Factor Info
didecyldimethylammonium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	didecyldimethylammonium results in increased expression of SLC7A11 mRNA		[155]
Regulation Mechanism			Transcription Factor Info
diethyl malate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	diethyl malate results in increased expression of SLC7A11 mRNA		[156]
Regulation Mechanism			Transcription Factor Info
diethyl maleate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	diethyl maleate results in increased expression of SLC7A11 mRNA		[157]
Regulation Mechanism			Transcription Factor Info
dimethylarsinous acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dimethylarsinous acid results in increased expression of SLC7A11 mRNA		[158]
Regulation Mechanism			Transcription Factor Info
Dimethyl Fumarate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dimethyl Fumarate inhibits the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein		[90]
Regulation Mechanism			Transcription Factor Info
Dimethylnitrosamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dimethylnitrosamine results in increased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
Diuron	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diuron results in decreased expression of SLC7A11 mRNA		[159]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	9 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dorsomorphin inhibits the reaction SIRT3 protein results in decreased expression of SLC7A11 protein		[160]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
elesclomol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction elesclomol results in increased expression of SLC7A11 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	elesclomol results in increased expression of SLC7A11 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
enniatins	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	enniatins results in increased expression of SLC7A11 mRNA		[162]
Regulation Mechanism			Transcription Factor Info
entacapone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entacapone results in decreased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of SLC7A11 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Epichlorohydrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Epichlorohydrin results in increased expression of SLC7A11 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
erastin	11 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction erastin results in increased expression of SLC7A11 protein		[163]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction indol-3-yl pyruvic acid co-treated with erastin results in increased expression of SLC7A11 protein		[163]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	AHR protein affects the reaction erastin results in increased expression of SLC7A11 mRNA		[163]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	AHR protein affects the reaction erastin results in increased expression of SLC7A11 protein		[163]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	AHR protein affects the reaction indol-3-yl pyruvic acid co-treated with erastin results in increased expression of SLC7A11 protein		[163]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	erastin results in decreased expression of SLC7A11 protein		[73]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	erastin results in increased expression of SLC7A11 mRNA		[163]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	erastin results in increased expression of SLC7A11 protein		[163]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	gap 27 peptide inhibits the reaction erastin results in decreased expression of SLC7A11 protein		[73]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	GJA1 protein affects the reaction erastin results in decreased expression of SLC7A11 protein		[73]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	indol-3-yl pyruvic acid co-treated with erastin results in increased expression of SLC7A11 protein		[163]
Regulation Mechanism			Transcription Factor Info
eriodictyol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	eriodictyol results in decreased expression of SLC7A11 protein		[164]
Regulation Mechanism			Transcription Factor Info
Ethanol	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CYP2E1 protein affects the susceptibility to Ethanol which affects the expression of SLC7A11 protein		[167]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Ethanol results in increased expression of SLC7A11 mRNA		[98]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	FXN protein affects the reaction CYP2E1 protein affects the susceptibility to Ethanol which affects the expression of SLC7A11 protein		[167]
Regulation Mechanism			Transcription Factor Info
ethyl acrylate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ethyl acrylate results in decreased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
ethylbenzene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ethylbenzene results in increased expression of SLC7A11 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
Etoposide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC7A11 protein affects the susceptibility to Etoposide		[149]
Regulation Mechanism			Transcription Factor Info
ferrostatin-1	9 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ferrostatin-1 affects the reaction 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SLC7A11 protein		[105]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ferrostatin-1 inhibits the reaction 1-nitropyrene results in decreased expression of SLC7A11 protein		[92]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ferrostatin-1 inhibits the reaction beta-lapachone results in decreased expression of SLC7A11 protein		[129]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	ferrostatin-1 inhibits the reaction Firemaster BP-6 results in decreased expression of SLC7A11 protein		[148]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	ferrostatin-1 inhibits the reaction isobavachalcone results in decreased expression of SLC7A11 mRNA		[168]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	ferrostatin-1 inhibits the reaction lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein		[169]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	ferrostatin-1 inhibits the reaction Nanotubes, Carbon results in decreased expression of SLC7A11 protein		[102]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	ferrostatin-1 inhibits the reaction ochratoxin A results in decreased expression of SLC7A11 protein		[88]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	ferrostatin-1 results in increased expression of SLC7A11 protein		[88]
Regulation Mechanism			Transcription Factor Info
fexofenadine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	fexofenadine results in decreased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Firemaster BP-6	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Curcumin inhibits the reaction Firemaster BP-6 results in decreased expression of SLC7A11 protein		[148]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Deferoxamine inhibits the reaction Firemaster BP-6 results in decreased expression of SLC7A11 protein		[148]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ferrostatin-1 inhibits the reaction Firemaster BP-6 results in decreased expression of SLC7A11 protein		[148]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Firemaster BP-6 results in decreased expression of SLC7A11 protein		[148]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	KEAP1 protein affects the reaction Firemaster BP-6 results in decreased expression of SLC7A11 protein		[148]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in decreased phosphorylation of SLC7A11 protein		[170]
Regulation Mechanism			Transcription Factor Info
gedunin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	gedunin results in increased expression of SLC7A11 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
Glutathione	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	BGN mRNA alternative form binds to OTUB1 protein which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein which results in increased chemical synthesis of Glutathione		[103]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione which results in decreased susceptibility to Hydrogen Peroxide		[54]
Regulation Mechanism			Transcription Factor Info
glycidamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	glycidamide results in increased expression of SLC7A11 mRNA		[171]
Regulation Mechanism			Transcription Factor Info
Glycochenodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of SLC7A11 mRNA		[110]
Regulation Mechanism			Transcription Factor Info
Glycocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of SLC7A11 mRNA		[110]
Regulation Mechanism			Transcription Factor Info
Glycodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of SLC7A11 mRNA		[110]
Regulation Mechanism			Transcription Factor Info
Hexachlorocyclohexane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hexachlorocyclohexane results in increased expression of SLC7A11 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Hydrogen Sulfide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium bisulfide results in increased abundance of Hydrogen Sulfide inhibits the reaction beryllium sulfate results in decreased expression of SLC7A11 mRNA		[128]
Regulation Mechanism			Transcription Factor Info
hydroquinone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	hydroquinone results in increased expression of SLC7A11 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
hydroxyhydroquinone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	hydroxyhydroquinone results in increased expression of SLC7A11 mRNA		[173]
Regulation Mechanism			Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in increased expression of SLC7A11 mRNA		[61]
Regulation Mechanism			Transcription Factor Info
indeno(1,2,3-cd)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	indeno(1,2,3-cd)pyrene results in increased expression of SLC7A11 mRNA		[174]
Regulation Mechanism			Transcription Factor Info
indol-3-yl pyruvic acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction indol-3-yl pyruvic acid co-treated with erastin results in increased expression of SLC7A11 protein		[163]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	AHR protein affects the reaction indol-3-yl pyruvic acid co-treated with erastin results in increased expression of SLC7A11 protein		[163]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	indol-3-yl pyruvic acid co-treated with erastin results in increased expression of SLC7A11 protein		[163]
Regulation Mechanism			Transcription Factor Info
indoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiazoles binds to indoline promotes the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein		[90]
Regulation Mechanism			Transcription Factor Info
isobavachalcone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ferrostatin-1 inhibits the reaction isobavachalcone results in decreased expression of SLC7A11 mRNA		[168]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	isobavachalcone results in decreased expression of SLC7A11 mRNA		[168]
Regulation Mechanism			Transcription Factor Info
Isoniazid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isoniazid results in increased expression of SLC7A11 mRNA		[175]
Regulation Mechanism			Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K 7174 results in increased expression of SLC7A11 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
lead acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	lead acetate results in increased expression of SLC7A11 mRNA		[177]
Regulation Mechanism			Transcription Factor Info
lumiracoxib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	lumiracoxib results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Maleic Anhydrides	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Maleic Anhydrides results in increased expression of SLC7A11 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
Malondialdehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	BGN mRNA alternative form binds to OTUB1 protein which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein which results in decreased abundance of Malondialdehyde		[103]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A11 mRNA		[122]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A11 mRNA		[122]
Regulation Mechanism			Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in increased expression of SLC7A11 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Mercuric Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mercuric Chloride results in increased expression of SLC7A11 mRNA		[95]
Regulation Mechanism			Transcription Factor Info
methacrylaldehyde	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC7A11 mRNA		[111]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC7A11 mRNA		[111]
Regulation Mechanism			Transcription Factor Info
Methylenebis(chloroaniline)	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methylenebis(chloroaniline) results in increased expression of SLC7A11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
Methylene Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methylene Chloride results in increased expression of SLC7A11 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in increased expression of SLC7A11 mRNA		[68]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in increased expression of SLC7A11 mRNA		[178]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC7A11 gene SNP affects the susceptibility to methylmercuric chloride		[97]
Regulation Mechanism			Transcription Factor Info
mono-(2-ethylhexyl)phthalate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mono-(2-ethylhexyl)phthalate results in decreased expression of SLC7A11 protein		[179]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	mono-(2-ethylhexyl)phthalate results in increased expression of SLC7A11 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	RSL3 compound promotes the reaction mono-(2-ethylhexyl)phthalate results in decreased expression of SLC7A11 protein		[179]
Regulation Mechanism			Transcription Factor Info
monomethylarsonous acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	monomethylarsonous acid results in increased expression of SLC7A11 mRNA		[158]
Regulation Mechanism			Transcription Factor Info
motexafin gadolinium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	motexafin gadolinium results in increased expression of SLC7A11 mRNA		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Zinc Acetate co-treated with motexafin gadolinium affects the expression of SLC7A11 mRNA		[7]
Regulation Mechanism			Transcription Factor Info
Naphthoquinones	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Naphthoquinones results in increased expression of SLC7A11 mRNA		[180]
Regulation Mechanism			Transcription Factor Info
neo-gambogic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	neo-gambogic acid results in decreased expression of SLC7A11 protein		[181]
Regulation Mechanism			Transcription Factor Info
Nevirapine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nevirapine results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nickel chloride results in increased expression of SLC7A11 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
nickel sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nickel sulfate results in increased expression of SLC7A11 mRNA		[183]
Regulation Mechanism			Transcription Factor Info
N-methyl-4-aminophenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC7A11 gene SNP affects the susceptibility to N-methyl-4-aminophenol		[97]
Regulation Mechanism			Transcription Factor Info
N-Nitrosopyrrolidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N-Nitrosopyrrolidine results in increased expression of SLC7A11 mRNA		[68]
Regulation Mechanism			Transcription Factor Info
NSC668394	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC668394 results in increased expression of SLC7A11 mRNA		[62]
Regulation Mechanism			Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in increased expression of SLC7A11 mRNA		[145]
Regulation Mechanism			Transcription Factor Info
nuciferine	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nuciferine inhibits the reaction Dehydroepiandrosterone results in decreased expression of SLC7A11 mRNA		[150]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	nuciferine inhibits the reaction Dehydroepiandrosterone results in decreased expression of SLC7A11 protein		[150]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	SOX2 protein promotes the reaction nuciferine inhibits the reaction Dehydroepiandrosterone results in decreased expression of SLC7A11 protein		[150]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC7A11 mRNA		[184]
Regulation Mechanism			Transcription Factor Info
Oxygen	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased abundance of Oxygen which results in increased expression of SLC7A11 mRNA		[142]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	cobaltous chloride results in decreased abundance of Oxygen which results in increased expression of SLC7A11 protein		[142]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	KDM4A protein affects the reaction cobaltous chloride results in decreased abundance of Oxygen which results in increased expression of SLC7A11 mRNA		[142]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	KDM4A protein affects the reaction cobaltous chloride results in decreased abundance of Oxygen which results in increased expression of SLC7A11 protein		[142]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Oxygen deficiency results in decreased expression of SLC7A11 mRNA		[135]
Regulation Mechanism			Transcription Factor Info
Ozone	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC7A11 mRNA		[111]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC7A11 mRNA		[111]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Ozone results in increased expression of SLC7A11 mRNA		[185]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Volatile Organic Compounds co-treated with Ozone results in decreased expression of SLC7A11 mRNA		[111]
Regulation Mechanism			Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in increased expression of SLC7A11 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
PCI 5002	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC7A11 mRNA		[187]
Regulation Mechanism			Transcription Factor Info
pentabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pentabromodiphenyl ether analog results in increased expression of SLC7A11 mRNA		[93]
Regulation Mechanism			Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in increased expression of SLC7A11 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in increased expression of SLC7A11 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
pinostrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pinostrobin results in increased expression of SLC7A11 mRNA		[188]
Regulation Mechanism			Transcription Factor Info
potassium bromate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium bromate results in increased expression of SLC7A11 mRNA		[189]
Regulation Mechanism			Transcription Factor Info
Procyclidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Procyclidine results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
prothioconazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	prothioconazole results in increased expression of SLC7A11 mRNA		[190]
Regulation Mechanism			Transcription Factor Info
racecadotril	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	racecadotril results in increased expression of SLC7A11 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
resorcinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	resorcinol results in decreased expression of SLC7A11 mRNA		[125]
Regulation Mechanism			Transcription Factor Info
Ropivacaine	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ropivacaine promotes the reaction Cisplatin results in decreased expression of SLC7A11 protein		[140]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Ropivacaine results in decreased expression of SLC7A11 protein		[191]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Ropivacaine results in increased susceptibility to Cisplatin which results in decreased expression of SLC7A11 protein		[140]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	SIRT1 protein affects the reaction Ropivacaine results in increased susceptibility to Cisplatin which results in decreased expression of SLC7A11 protein		[140]
Regulation Mechanism			Transcription Factor Info
rutecarpine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	rutecarpine results in increased expression of SLC7A11 mRNA		[192]
Regulation Mechanism			Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides results in increased expression of SLC7A11 mRNA		[193]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	S-(1,2-dichlorovinyl)cysteine promotes the reaction Lipopolysaccharides results in increased expression of SLC7A11 mRNA		[193]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	S-(1,2-dichlorovinyl)cysteine results in increased expression of SLC7A11 mRNA		[194]
Regulation Mechanism			Transcription Factor Info
Selenium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC7A11 mRNA results in increased import of Selenium		[195]
Regulation Mechanism			Transcription Factor Info
shikonin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATF3 protein promotes the reaction shikonin results in decreased expression of SLC7A11 protein		[196]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	shikonin results in decreased expression of SLC7A11 protein		[196]
Regulation Mechanism			Transcription Factor Info
shogaol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	shogaol results in decreased expression of SLC7A11 mRNA		[75]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	shogaol results in decreased expression of SLC7A11 protein		[75]
Regulation Mechanism			Transcription Factor Info
Silver	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver results in increased expression of SLC7A11 mRNA		[197]
Regulation Mechanism			Transcription Factor Info
sinpeinine A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sinpeinine A results in decreased expression of SLC7A11 mRNA		[198]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sinpeinine A results in decreased expression of SLC7A11 protein		[198]
Regulation Mechanism			Transcription Factor Info
Sirolimus	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sirolimus inhibits the reaction Nanotubes, Carbon results in decreased expression of SLC7A11 protein		[102]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sirolimus inhibits the reaction SIRT3 protein results in decreased expression of SLC7A11 protein		[160]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of SLC7A11 gene		[199]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in decreased expression of SLC7A11 mRNA		[71]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A11 mRNA		[122]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC7A11 mRNA		[122]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	sodium arsenite results in increased expression of SLC7A11 mRNA		[200]
Regulation Mechanism			Transcription Factor Info
sodium bisulfide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium bisulfide results in increased abundance of Hydrogen Sulfide inhibits the reaction beryllium sulfate results in decreased expression of SLC7A11 mRNA		[128]
Regulation Mechanism			Transcription Factor Info
Sodium Dodecyl Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Dodecyl Sulfate results in increased expression of SLC7A11 mRNA		[65]
Regulation Mechanism			Transcription Factor Info
Sodium Fluoride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Fluoride results in decreased expression of SLC7A11 mRNA		[201]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium Fluoride results in decreased expression of SLC7A11 protein		[201]
Regulation Mechanism			Transcription Factor Info
Sodium Hypochlorite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Hypochlorite results in increased expression of SLC7A11 mRNA		[98]
Regulation Mechanism			Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite results in increased expression of SLC7A11 mRNA		[202]
Regulation Mechanism			Transcription Factor Info
solasodine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	solasodine results in decreased expression of SLC7A11 protein		[203]
Regulation Mechanism			Transcription Factor Info
Sorafenib	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC7A11 protein affects the reaction SNHG1 protein results in decreased susceptibility to Sorafenib		[151]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sorafenib promotes the reaction arsenic disulfide results in decreased expression of SLC7A11 protein		[204]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Sorafenib results in decreased expression of SLC7A11 protein		[204]
Regulation Mechanism			Transcription Factor Info
Succimer	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Succimer co-treated with Magnetite Nanoparticles results in increased expression of SLC7A11 mRNA		[205]
Regulation Mechanism			Transcription Factor Info
sulforaphane	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SIRT3 protein promotes the reaction sulforaphane results in decreased expression of SLC7A11 protein		[160]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sulforaphane results in decreased expression of SLC7A11 protein		[160]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sulforaphane results in increased expression of SLC7A11 mRNA		[206]
Regulation Mechanism			Transcription Factor Info
tanshinone II A sodium sulfonate	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tanshinone II A sodium sulfonate affects the expression of SLC7A11 mRNA		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	tanshinone II A sodium sulfonate inhibits the reaction PIAS4 protein results in increased sumoylation of SLC7A11 protein which results in decreased susceptibility to Cisplatin		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	tanshinone II A sodium sulfonate inhibits the reaction SLC7A11 protein results in decreased susceptibility to Cisplatin		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	tanshinone II A sodium sulfonate results in decreased expression of SLC7A11 mRNA		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	tanshinone II A sodium sulfonate results in decreased expression of SLC7A11 protein		[139]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	tanshinone II A sodium sulfonate results in increased expression of SLC7A11 protein		[139]
Regulation Mechanism			Transcription Factor Info
tempol	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NFE2L2 protein affects the reaction tempol inhibits the reaction lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein		[169]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	tempol inhibits the reaction lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein		[169]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	tempol promotes the reaction NFE2L2 protein inhibits the reaction lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein		[169]
Regulation Mechanism			Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide results in increased expression of SLC7A11 mRNA		[172]
Regulation Mechanism			Transcription Factor Info
tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A results in increased expression of SLC7A11 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Endosulfan co-treated with Tetrachlorodibenzodioxin results in increased expression of SLC7A11 mRNA		[161]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin affects the expression of SLC7A11 mRNA		[112]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin results in decreased expression of SLC7A11 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Tetrachlorodibenzodioxin results in increased expression of SLC7A11 mRNA		[161]
Regulation Mechanism			Transcription Factor Info
tetrathiomolybdate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tetrathiomolybdate analog results in increased expression of SLC7A11 mRNA		[207]
Regulation Mechanism			Transcription Factor Info
Thiazoles	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiazoles binds to indoline promotes the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein		[90]
Regulation Mechanism			Transcription Factor Info
triacsin C	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triacsin C results in increased expression of SLC7A11 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A11 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of SLC7A11 mRNA		[208]
Regulation Mechanism			Transcription Factor Info
Triiodothyronine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Triiodothyronine results in increased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
tri-o-cresyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tri-o-cresyl phosphate results in increased expression of SLC7A11 mRNA		[209]
Regulation Mechanism			Transcription Factor Info
tris(2-butoxyethyl) phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(2-butoxyethyl) phosphate affects the expression of SLC7A11 mRNA		[210]
Regulation Mechanism			Transcription Factor Info
valtrate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC7A11 protein inhibits the reaction valtrate results in decreased expression of GPX4 protein		[211]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	valtrate results in decreased expression of SLC7A11 protein		[211]
Regulation Mechanism			Transcription Factor Info
vanillin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	vanillin results in increased expression of SLC7A11 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 results in increased expression of SLC7A11 mRNA		[172]
Regulation Mechanism			Transcription Factor Info
zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zafirlukast results in decreased expression of SLC7A11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Zinc	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC7A11 mRNA		[187]
Regulation Mechanism			Transcription Factor Info
Ziram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ziram results in increased expression of SLC7A11 mRNA		[83]
Regulation Mechanism			Transcription Factor Info

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