Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0394 Transporter Info
Gene Name SLC52A2
Transporter Name Riboflavin transporter 3
Gene ID
79581
UniProt ID
Q9HAB3
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Valproic Acid results in increased methylation of SLC52A2 gene [24]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Estradiol affects the expression of SLC52A2 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC52A2 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  Acrolein

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC52A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC52A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  alpha-pinene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC52A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC52A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  beta-lapachone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-lapachone results in increased expression of SLC52A2 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  beta-methylcholine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-methylcholine affects the expression of SLC52A2 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A affects the expression of SLC52A2 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 bisphenol A results in decreased expression of SLC52A2 mRNA [7]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 bisphenol A results in decreased methylation of SLC52A2 gene [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 bisphenol A results in increased expression of SLC52A2 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  Cadmium Chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC52A2 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  Dactinomycin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dactinomycin co-treated with nutlin 3 results in increased expression of SLC52A2 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  di-n-butylphosphoric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 di-n-butylphosphoric acid affects the expression of SLC52A2 mRNA [19]

Regulation Mechanism

 Transcription Factor Info

  methacrylaldehyde

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC52A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC52A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  Methotrexate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC52A2 protein affects the susceptibility to Methotrexate [21]

Regulation Mechanism

 Transcription Factor Info

  nutlin 3

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dactinomycin co-treated with nutlin 3 results in increased expression of SLC52A2 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  Okadaic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Okadaic Acid results in increased expression of SLC52A2 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

  Ozone

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC52A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC52A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Volatile Organic Compounds co-treated with Ozone affects the expression of SLC52A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine increases the expression of SLC52A2 [1]

  Valproic Acid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid increases the expression of SLC52A2 [2]

  Acetaminophen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acetaminophen increases the expression of SLC52A2 [3]

  Estradiol

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol increases the expression of SLC52A2 [4]

  Temozolomide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Temozolomide increases the expression of SLC52A2 [5]

Drug in Phase 2 Trial

  Bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol A inhibits the expression of SLC52A2 [7]

Investigative Drug

  4-Cyclohexyl-4-hydroxy-but-2-enoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-Cyclohexyl-4-hydroxy-but-2-enoic acid inhibits the activity of SLC52A2 [10]

  4-Hydroxy-3-methyl-but-2-enoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-Hydroxy-3-methyl-but-2-enoic acid inhibits the activity of SLC52A2 [10]

  4-Hydroxy-3-methyl-butyric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-Hydroxy-3-methyl-butyric acid inhibits the activity of SLC52A2 [10]

  4-Hydroxy-4-phenyl-but-2-enoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-Hydroxy-4-phenyl-but-2-enoic acid inhibits the activity of SLC52A2 [10]

  4-Hydroxy-4-phenyl-butyric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-Hydroxy-4-phenyl-butyric acid inhibits the activity of SLC52A2 [10]

  4-Hydroxy-but-2-enoate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-Hydroxy-but-2-enoate inhibits the activity of SLC52A2 [10]

  4-Hydroxy-pent-2-enoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-Hydroxy-pent-2-enoic acid inhibits the activity of SLC52A2 [10]

  5-Hydroxy-pentanoate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 5-Hydroxy-pentanoate inhibits the activity of SLC52A2 [10]

  4-Hydroxy-pentanoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-Hydroxy-pentanoic acid inhibits the activity of SLC52A2 [10]

Natural Product

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution increases the expression of SLC52A2 [9]

  Resveratrol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Plant Extracts co-treated with Resveratrol results in decreased expression of SLC52A2 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

Mycotoxins

  Aflatoxin B1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 increases the expression of SLC52A2 [6]

Carcinogen

  Benzo(a)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene increases the expression of SLC52A2 [8]

  Cadmium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC52A2 mRNA [17]

Regulation Mechanism

 Transcription Factor Info
References
1 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
2 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
3 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
4 17 beta-Estradiol Activates HSF1 via MAPK Signaling in ER alpha-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533.
5 Temozolomide induces activation of Wnt/beta-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278.
6 Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):176-87.
7 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
8 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
9 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
10 Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7.
11 Temporal gene expression changes induced by a low concentration of benzo[a]pyrene diol epoxide in a normal human cell line. Mutat Res. 2010;684(1-2):74-80.
12 Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes. Commun Biol. 2020;3(1):392.
13 Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway. Chem Biol Interact. 2024;389:110866.
14 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352.
15 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134.
16 Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
17 Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes. Toxicology. 2022;470:153153.
18 Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes. Chem Biol Interact. 2024;392:110946.
19 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
20 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711.
21 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006;118(7):1699-712.
22 A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
23 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.
24 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

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