Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0366 Transporter Info
Gene Name SLC44A4
Transporter Name Choline transporter-like protein 4
Gene ID
80736
UniProt ID
Q53GD3
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Testosterone co-treated with Calcitriol results in increased expression of SLC44A4 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Testosterone co-treated with Calcitriol results in increased expression of SLC44A4 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  1-Butanol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC44A4 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

  4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC44A4 mRNA [7]

Regulation Mechanism

 Transcription Factor Info

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in increased expression of SLC44A4 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  beta-lapachone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-lapachone results in decreased expression of SLC44A4 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A affects the methylation of SLC44A4 gene [13]

Regulation Mechanism

 Transcription Factor Info

  Cadmium Chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium Chloride results in increased expression of SLC44A4 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  CGP 52608

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CGP 52608 promotes the reaction RORA protein binds to SLC44A4 gene [15]

Regulation Mechanism

 Transcription Factor Info

  chloropicrin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 chloropicrin results in increased expression of SLC44A4 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  Deferoxamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Deferoxamine results in decreased expression of SLC44A4 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  erucylphospho-N,N,N-trimethylpropylammonium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 erucylphospho-N,N,N-trimethylpropylammonium results in increased expression of SLC44A4 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  Fonofos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fonofos results in increased methylation of SLC44A4 promoter [19]

Regulation Mechanism

 Transcription Factor Info

  Gasoline

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC44A4 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

  ICG 001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG 001 results in increased expression of SLC44A4 mRNA [7]

Regulation Mechanism

 Transcription Factor Info

  licochalcone B

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 licochalcone B results in increased expression of SLC44A4 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  Mustard Gas

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Mustard Gas results in increased expression of SLC44A4 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  Oxygen

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 HIF1A protein affects the reaction Oxygen deficiency results in decreased expression of SLC44A4 protein [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Oxygen deficiency results in decreased expression of SLC44A4 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Oxygen deficiency results in decreased expression of SLC44A4 protein [17]

Regulation Mechanism

 Transcription Factor Info

  Parathion

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Parathion results in increased methylation of SLC44A4 promoter [19]

Regulation Mechanism

 Transcription Factor Info

  Selenium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Selenium results in increased expression of SLC44A4 mRNA [5]

Regulation Mechanism

 Transcription Factor Info

  terbufos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 terbufos results in increased methylation of SLC44A4 promoter [19]

Regulation Mechanism

 Transcription Factor Info

  tert-Butylhydroperoxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 tert-Butylhydroperoxide affects the expression of SLC44A4 mRNA [2]

Regulation Mechanism

 Transcription Factor Info

  Vitamin K 3

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vitamin K 3 affects the expression of SLC44A4 mRNA [2]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Calcitriol

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Calcitriol increases the expression of SLC44A4 [1]

  Testosterone

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Testosterone increases the expression of SLC44A4 [1]

  Menadione

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Menadione affects the expression of SLC44A4 [2]

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the expression of SLC44A4 [3]

  Urethane

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Urethane inhibits the expression of SLC44A4 [4]

  Hydrogen Peroxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Hydrogen Peroxide affects the expression of SLC44A4 [2]

Patented Pharmaceutical Agent

  ICG-001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG-001 increases the expression of SLC44A4 [7]

Natural Product

  Selenium nanoparticles

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Selenium nanoparticles increases the expression of SLC44A4 [5]

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution affects the expression of SLC44A4 [8]

  Resveratrol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Plant Extracts co-treated with Resveratrol results in decreased expression of SLC44A4 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

Acute Toxic Substance

  Cadmium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium inhibits the expression of SLC44A4 [6]

  Chloropicrin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Chloropicrin increases the expression of SLC44A4 [9]
References
1 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
2 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
3 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
4 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
5 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
6 Using expression profiling to understand the effects of chronic cadmium exposure on MCF-7 breast cancer cells. PLoS One. 2013 Dec 20;8(12):e84646.
7 Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
8 Multi-omics analysis: Repeated exposure of a 3D bronchial tissue culture to whole-cigarette smoke. Toxicol In Vitro. 2019 Feb;54:251-262.
9 Molecular targets of chloropicrin in human airway epithelial cells. Toxicol In Vitro. 2017 Aug;42:247-254.
10 Transcriptional response to organic compounds from diverse gasoline and biogasoline fuel emissions in human lung cells. Toxicol In Vitro. 2018;48:329-341.
11 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
12 Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway. Chem Biol Interact. 2024;389:110866.
13 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
14 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
15 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
16 Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
17 Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1alpha-mediated transcriptional regulation of their transporters. J Biol Chem. 2022 Feb;298(2):101562.
18 Upregulation of cell cycle genes in head and neck cancer patients may be antagonized by erufosine's down regulation of cell cycle processes in OSCC cells. Oncotarget. 2018;9(5):5797-5810.
19 DNA methylation alterations in response to pesticide exposure in vitro. Environ Mol Mutagen. 2012;53(7):542-9.
20 Integrated miRNA and mRNA omics reveal the anti-cancerous mechanism of Licochalcone B on Human Hepatoma Cell HepG2. Food Chem Toxicol. 2021;150:112096.
21 Whole genome expression analysis in primary bronchial epithelial cells after exposure to sulphur mustard. Toxicol Lett. 2014;230(3):393-401.
22 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.

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