Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0352 Transporter Info
Gene Name	SLC3A2
Transporter Name	Lymphocyte activation antigen 4F2
Gene ID	6520
UniProt ID	P08195

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Approved Drug
Sulindac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulindac increases the expression of SLC3A2			[1]
Fluorouracil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluorouracil increases the expression of SLC3A2			[2]
Tamoxifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen increases the expression of SLC3A2			[3]
Bicalutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bicalutamide increases the expression of SLC3A2			[4]
Zinc Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zinc Acetate increases the expression of SLC3A2			[5]
Raloxifene Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride increases the expression of SLC3A2			[6]
Indomethacin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin increases the expression of SLC3A2			[7]
Ethinyl Estradiol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol increases the expression of SLC3A2			[8]
Phenobarbital	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital increases the expression of SLC3A2			[9]
Troglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troglitazone increases the expression of SLC3A2			[10]
Diethylstilbestrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylstilbestrol increases the expression of SLC3A2			[11]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of SLC3A2			[12]
Amiodarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amiodarone increases the expression of SLC3A2			[13]
Arsenic	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic increases the expression of SLC3A2			[14]
Piroxicam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the expression of SLC3A2			[16]
Azathioprine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azathioprine increases the expression of SLC3A2			[17]
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine affects the expression of SLC3A2			[18]
Zidovudine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC3A2			[19]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC3A2			[20]
Cyclophosphamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclophosphamide inhibits the expression of SLC3A2			[20]
Lindane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lindane increases the expression of SLC3A2			[20]
Dexamethasone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone inhibits the expression of SLC3A2			[21]
Cidofovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cidofovir increases the expression of SLC3A2			[22]
Fenofibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenofibrate increases the expression of SLC3A2			[22]
Ibuprofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen increases the expression of SLC3A2			[22]
Ifosfamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ifosfamide increases the expression of SLC3A2			[22]
Rosiglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone increases the expression of SLC3A2			[22]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of SLC3A2			[23]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC3A2			[24]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of SLC3A2			[25]
Dronabinol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dronabinol inhibits the expression of SLC3A2			[26]
Bosentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bosentan increases the expression of SLC3A2			[27]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC3A2			[28]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Temozolomide increases the expression of SLC3A2			[29]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC3A2			[30]
Celecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib increases the expression of SLC3A2			[32]
Clozapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clozapine increases the expression of SLC3A2			[33]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of SLC3A2			[34]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC3A2			[35]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC3A2			[36]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of SLC3A2			[22]
Cisplatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of SLC3A2			[37]
Regulation Mechanism	via enhancement of Zinc finger E-box-binding homeobox 1 (ZEB1)			Transcription Factor Info
Affected Drug/Substrate	Cisplatin	Modulation Type	Inhibition
Cell System	Human ovarian serous cystadenocarcinoma cells (SK-OV-3)
Drug Marketed but not Approved by US FDA
Gamolenic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gamolenic acid increases the expression of SLC3A2			[15]
Clodronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clodronic Acid affects the expression of SLC3A2			[22]
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rotenone inhibits the expression of SLC3A2			[31]
Drug in Phase 3 Trial
Fenretinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenretinide increases the expression of SLC3A2			[40]
Curcumin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Curcumin increases the expression of SLC3A2			[42]
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulforafan inhibits the expression of SLC3A2			[70]
Drug in Phase 2 Trial
Sulindac sulfide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulindac sulfide increases the expression of SLC3A2			[39]
Motexafin gadolinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Motexafin gadolinium increases the expression of SLC3A2			[5]
MS-275	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of SLC3A2			[56]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC3A2			[64]
Bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol B increases the expression of SLC3A2			[69]
Andrographolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Andrographolide inhibits the expression of SLC3A2			[70]
Genistein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLC3A2			[71]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin increases the expression of SLC3A2			[46]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC3A2			[61]
Drug in Preclinical Test
Tripterine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tripterine increases the expression of SLC3A2			[41]
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC3A2			[48]
Investigative Drug
Beta-naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beta-naphthoflavone increases the expression of SLC3A2			[45]
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of SLC3A2			[56]
NSC-305787	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC-305787 increases the expression of SLC3A2			[58]
Patented Pharmaceutical Agent
K-7174	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	K-7174 increases the expression of SLC3A2			[50]
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG-001 increases the expression of SLC3A2			[55]
NSC-668394	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC-668394 increases the expression of SLC3A2			[58]
GSK-J4	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK-J4 increases the expression of SLC3A2			[62]
Natural Product
Gedunin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gedunin increases the expression of SLC3A2			[41]
Coal Ash	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coal Ash increases the expression of SLC3A2			[43]
Selenium nanoparticles	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selenium nanoparticles increases the expression of SLC3A2			[44]
Bilirubin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bilirubin increases the expression of SLC3A2			[47]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of SLC3A2			[63]
Methylparaben	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methylparaben increases the expression of SLC3A2			[65]
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyleugenol increases the expression of SLC3A2			[66]
Deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deguelin increases the expression of SLC3A2			[31]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC3A2			[72]
Thapsigargin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thapsigargin increases the expression of SLC3A2			[73]
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant Extracts co-treated with Resveratrol results in increased expression of SLC3A2 mRNA			[132]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol F increases the expression of SLC3A2			[69]
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of SLC3A2			[57]
Mercury	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC3A2 protein affects the import of Mercury			[102]
Regulation Mechanism				Transcription Factor Info
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC3A2			[59]
DT Modulation2	Aflatoxin B1 results in increased methylation of SLC3A2 gene			[59]
Regulation Mechanism				Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in increased expression of SLC3A2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formaldehyde increases the expression of SLC3A2			[49]
Cadmium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium increases the expression of SLC3A2			[51]
Cycloheximide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cycloheximide increases the expression of SLC3A2			[57]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrylamide increases the expression of SLC3A2			[68]
Antimycin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Antimycin A increases the expression of SLC3A2			[31]
Paraquat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paraquat increases the expression of SLC3A2			[74]
Carcinogen
DT Modulation1	Arsenic results in decreased ubiquitination of SLC3A2 protein			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC3A2 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC3A2 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate increases the expression of SLC3A2			[49]
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC3A2			[20]
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC3A2 mRNA			[98]
Regulation Mechanism				Transcription Factor Info
Fungicide
Azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azoxystrobin inhibits the expression of SLC3A2			[31]
Health and Environmental Toxicant
Lithium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lithium Chloride increases the expression of SLC3A2			[38]
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium increases the expression of SLC3A2			[52]
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate increases the expression of SLC3A2			[54]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid increases the expression of SLC3A2			[67]
Nanoparticle
Silver nanoparticle	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silver nanoparticle increases the expression of SLC3A2			[53]
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of SLC3A2 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
Chemical Compound
DT Modulation1	SLC3A2 protein affects the susceptibility to Fluorouracil			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Zinc Acetate co-treated with motexafin gadolinium affects the expression of SLC3A2 mRNA			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of SLC3A2 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ethinyl Estradiol affects the expression of SLC3A2 mRNA			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenobarbital affects the expression of SLC3A2 mRNA			[130]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Zidovudine co-treated with Lamivudine results in increased expression of SLC3A2 mRNA			[120]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of SLC3A2 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dronabinol affects the expression of SLC3A2 mRNA			[110]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	EGF protein promotes the reaction Estradiol results in increased expression of SLC3A2 mRNA			[111]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC3A2 mRNA			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Hydralazine co-treated with Valproic Acid results in increased expression of SLC3A2 mRNA			[117]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC3A2 mRNA			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cisplatin affects the expression of SLC3A2 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cisplatin co-treated with jinfukang results in decreased expression of SLC3A2 mRNA			[100]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione which results in decreased susceptibility to Hydrogen Peroxide			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in increased expression of SLC3A2 mRNA			[91]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
Tungsten	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tungsten increases the expression of SLC3A2			[60]
DT Modulation1	ESR1 promotes the reaction Genistein results in increased expression of SLC3A2 protein			[115]
Regulation Mechanism				Transcription Factor Info
1-Butanol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC3A2 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
1-Methyl-3-isobutylxanthine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of SLC3A2 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
1-Methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium results in increased expression of SLC3A2 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of SLC3A2 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
2,5,2',5'-tetrachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,5,2',5'-tetrachlorobiphenyl results in increased expression of SLC3A2 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC3A2 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC3A2 protein			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of SLC3A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of SLC3A2 mRNA			[81]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in increased expression of SLC3A2 mRNA			[82]
Regulation Mechanism				Transcription Factor Info
Acrolein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC3A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC3A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in increased expression of SLC3A2 mRNA			[84]
Regulation Mechanism				Transcription Factor Info
alpha-pinene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC3A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC3A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
andrographolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	andrographolide results in decreased expression of SLC3A2 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in increased expression of SLC3A2 mRNA			[85]
Regulation Mechanism				Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite affects the expression of SLC3A2 mRNA			[88]
Regulation Mechanism				Transcription Factor Info
Asbestos, Serpentine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asbestos, Serpentine results in increased expression of SLC3A2 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azoxystrobin results in decreased expression of SLC3A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
bardoxolone methyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bardoxolone methyl results in decreased expression of SLC3A2 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
beauvericin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beauvericin co-treated with enniatins results in increased expression of SLC3A2 protein			[90]
Regulation Mechanism				Transcription Factor Info
benz(a)anthracene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benz(a)anthracene results in increased expression of SLC3A2 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
Benztropine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cuprizone co-treated with Benztropine results in increased expression of SLC3A2 protein			[92]
Regulation Mechanism				Transcription Factor Info
beta-lapachone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-lapachone affects the expression of SLC3A2 mRNA			[93]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	beta-lapachone results in decreased expression of SLC3A2 protein			[93]
Regulation Mechanism				Transcription Factor Info
beta-Naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-Naphthoflavone results in increased expression of SLC3A2 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
bicalutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bicalutamide results in increased expression of SLC3A2 mRNA			[4]
Regulation Mechanism				Transcription Factor Info
bisphenol A	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC3A2 mRNA			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A affects the methylation of SLC3A2 gene			[95]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A co-treated with Fulvestrant results in decreased methylation of SLC3A2 gene			[95]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	bisphenol A results in decreased expression of SLC3A2 protein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	bisphenol A results in increased expression of SLC3A2 mRNA			[96]
Regulation Mechanism				Transcription Factor Info
bisphenol AF	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol AF results in increased expression of SLC3A2 protein			[69]
Regulation Mechanism				Transcription Factor Info
bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol B results in increased expression of SLC3A2 protein			[69]
Regulation Mechanism				Transcription Factor Info
bisphenol F	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F results in increased expression of SLC3A2 protein			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of SLC3A2 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
boron nitride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	boron nitride results in increased expression of SLC3A2 mRNA			[97]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC3A2 mRNA			[99]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC3A2 mRNA			[98]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased expression of SLC3A2 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
Cannabidiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cuprizone co-treated with Cannabidiol results in increased expression of SLC3A2 protein			[92]
Regulation Mechanism				Transcription Factor Info
celastrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	celastrol results in increased expression of SLC3A2 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
chloroacetaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chloroacetaldehyde results in increased expression of SLC3A2 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
chrysene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chrysene results in increased expression of SLC3A2 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in increased expression of SLC3A2 mRNA			[101]
Regulation Mechanism				Transcription Factor Info
Colforsin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colforsin results in increased expression of SLC3A2 mRNA			[102]
Regulation Mechanism				Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in increased expression of SLC3A2 mRNA			[103]
Regulation Mechanism				Transcription Factor Info
Cuprizone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cuprizone co-treated with Benztropine results in increased expression of SLC3A2 protein			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cuprizone co-treated with Cannabidiol results in increased expression of SLC3A2 protein			[92]
Regulation Mechanism				Transcription Factor Info
Cystine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione which results in decreased susceptibility to Hydrogen Peroxide			[47]
Regulation Mechanism				Transcription Factor Info
Dactinomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dactinomycin inhibits the reaction Vehicle Emissions results in increased expression of SLC3A2 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	deguelin results in increased expression of SLC3A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
deoxynivalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	deoxynivalenol results in decreased expression of SLC3A2 protein			[104]
Regulation Mechanism				Transcription Factor Info
diethyl maleate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diethyl maleate results in increased expression of SLC3A2 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
dimethylarsinous acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dimethylarsinous acid results in increased expression of SLC3A2 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC3A2 mRNA			[107]
Regulation Mechanism				Transcription Factor Info
Diquat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diquat results in increased expression of SLC3A2 protein			[108]
Regulation Mechanism				Transcription Factor Info
Diuron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diuron results in decreased expression of SLC3A2 mRNA			[109]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
enniatins	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beauvericin co-treated with enniatins results in increased expression of SLC3A2 protein			[90]
Regulation Mechanism				Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of SLC3A2 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
Estrogens	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in increased expression of SLC3A2 mRNA			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estrogens results in increased expression of SLC3A2 mRNA			[84]
Regulation Mechanism				Transcription Factor Info
Ethanol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with Ethanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC3A2 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
fenpyroximate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	fenpyroximate results in increased expression of SLC3A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FR900359 results in increased phosphorylation of SLC3A2 protein			[113]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in decreased methylation of SLC3A2 gene			[95]
Regulation Mechanism				Transcription Factor Info
Furaldehyde	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC3A2 protein			[114]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with Furaldehyde results in increased expression of SLC3A2 protein			[114]
Regulation Mechanism				Transcription Factor Info
gamma-Linolenic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	gamma-Linolenic Acid results in increased expression of SLC3A2 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
Gasoline	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC3A2 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Gasoline co-treated with Ethanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC3A2 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Gasoline results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC3A2 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
gedunin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	gedunin results in increased expression of SLC3A2 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Glutathione	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione which results in decreased susceptibility to Hydrogen Peroxide			[47]
Regulation Mechanism				Transcription Factor Info
gossypol acetic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	gossypol acetic acid results in increased expression of SLC3A2 protein			[116]
Regulation Mechanism				Transcription Factor Info
Hexachlorocyclohexane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hexachlorocyclohexane results in increased expression of SLC3A2 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
Hydralazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydralazine co-treated with Valproic Acid results in increased expression of SLC3A2 mRNA			[117]
Regulation Mechanism				Transcription Factor Info
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bilirubin results in increased activity of SLC7A11 protein co-treated with SLC3A2 protein which results in increased uptake of Cystine which results in increased abundance of Glutathione which results in decreased susceptibility to Hydrogen Peroxide			[47]
Regulation Mechanism				Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in increased expression of SLC3A2 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
Ionomycin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrrolidine dithiocarbamic acid inhibits the reaction Tetradecanoylphorbol Acetate co-treated with Ionomycin results in increased expression of SLC3A2 mRNA			[118]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetradecanoylphorbol Acetate co-treated with Ionomycin results in increased expression of SLC3A2 mRNA			[118]
Regulation Mechanism				Transcription Factor Info
Isoniazid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isoniazid results in decreased expression of SLC3A2 protein			[119]
Regulation Mechanism				Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	K 7174 results in increased expression of SLC3A2 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
Lamivudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine co-treated with Lamivudine results in increased expression of SLC3A2 mRNA			[120]
Regulation Mechanism				Transcription Factor Info
LDN 193189	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC3A2 protein			[79]
Regulation Mechanism				Transcription Factor Info
lead acetate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lead acetate results in increased expression of SLC3A2 mRNA			[121]
Regulation Mechanism				Transcription Factor Info
Leucine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC3A2 protein affects the import of Leucine			[102]
Regulation Mechanism				Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC3A2 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC3A2 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
Mercaptoethanol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mercaptoethanol promotes the reaction Mercuric Chloride inhibits the reaction SLC3A2 protein results in increased uptake of Amino Acids, Peptides, and Proteins			[122]
Regulation Mechanism				Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in increased expression of SLC3A2 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
Mercuric Chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mercaptoethanol promotes the reaction Mercuric Chloride inhibits the reaction SLC3A2 protein results in increased uptake of Amino Acids, Peptides, and Proteins			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mercuric Chloride inhibits the reaction SLC3A2 protein results in increased uptake of Amino Acids, Peptides, and Proteins			[122]
Regulation Mechanism				Transcription Factor Info
methacrylaldehyde	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC3A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC3A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in increased expression of SLC3A2 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in increased expression of SLC3A2 mRNA			[123]
Regulation Mechanism				Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in increased expression of SLC3A2 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
methylparaben	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylparaben results in increased expression of SLC3A2 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
monomethylarsonous acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	monomethylarsonous acid results in increased expression of SLC3A2 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	monomethylarsonous acid results in increased expression of SLC3A2 protein			[124]
Regulation Mechanism				Transcription Factor Info
motexafin gadolinium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	motexafin gadolinium results in increased expression of SLC3A2 mRNA			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Zinc Acetate co-treated with motexafin gadolinium affects the expression of SLC3A2 mRNA			[5]
Regulation Mechanism				Transcription Factor Info
Naphthoquinones	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naphthoquinones results in increased expression of SLC3A2 mRNA			[125]
Regulation Mechanism				Transcription Factor Info
N-Nitrosopyrrolidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-Nitrosopyrrolidine results in increased expression of SLC3A2 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
NSC305787	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC305787 results in increased expression of SLC3A2 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
NSC668394	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC668394 results in increased expression of SLC3A2 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in increased expression of SLC3A2 mRNA			[103]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC3A2 mRNA			[126]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Okadaic Acid results in increased expression of SLC3A2 protein			[126]
Regulation Mechanism				Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in increased expression of SLC3A2 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
Ozone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC3A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC3A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Air Pollutants results in increased abundance of Ozone which affects the expression of SLC3A2 mRNA			[127]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Volatile Organic Compounds co-treated with Ozone results in decreased expression of SLC3A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC3A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in increased expression of SLC3A2 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
PCI 5002	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC3A2 mRNA			[128]
Regulation Mechanism				Transcription Factor Info
pentabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pentabromodiphenyl ether analog results in increased expression of SLC3A2 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in increased expression of SLC3A2 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens results in decreased expression of SLC3A2 mRNA			[129]
Regulation Mechanism				Transcription Factor Info
Phytoestrogens	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens results in decreased expression of SLC3A2 mRNA			[129]
Regulation Mechanism				Transcription Factor Info
pyrachlostrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrachlostrobin results in increased expression of SLC3A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
pyrogallol 1,3-dimethyl ether	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of SLC3A2 protein			[114]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC3A2 protein			[114]
Regulation Mechanism				Transcription Factor Info
pyrrolidine dithiocarbamic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrrolidine dithiocarbamic acid inhibits the reaction Tetradecanoylphorbol Acetate co-treated with Ionomycin results in increased expression of SLC3A2 mRNA			[118]
Regulation Mechanism				Transcription Factor Info
quinocetone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quinocetone results in decreased expression of SLC3A2 mRNA			[131]
Regulation Mechanism				Transcription Factor Info
Roscovitine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Roscovitine inhibits the reaction Vehicle Emissions results in increased expression of SLC3A2 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
rutecarpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rutecarpine results in increased expression of SLC3A2 mRNA			[133]
Regulation Mechanism				Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine results in increased expression of SLC3A2 mRNA			[134]
Regulation Mechanism				Transcription Factor Info
Selenium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selenium results in increased expression of SLC3A2 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of SLC3A2 mRNA			[135]
Regulation Mechanism				Transcription Factor Info
Silver	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silver results in increased expression of SLC3A2 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
sinpeinine A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sinpeinine A results in decreased expression of SLC3A2 mRNA			[136]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC3A2 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC3A2 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in increased expression of SLC3A2 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
Sodium Chloride	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC3A2 protein			[114]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with Furaldehyde results in increased expression of SLC3A2 protein			[114]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of SLC3A2 protein			[114]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC3A2 protein			[114]
Regulation Mechanism				Transcription Factor Info
sulforaphane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in decreased expression of SLC3A2 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
sulindac sulfide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulindac sulfide results in increased expression of SLC3A2 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction Tetrachlorodibenzodioxin results in increased expression of SLC3A2 mRNA			[137]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in increased expression of SLC3A2 mRNA			[138]
Regulation Mechanism				Transcription Factor Info
Tetradecanoylphorbol Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrrolidine dithiocarbamic acid inhibits the reaction Tetradecanoylphorbol Acetate co-treated with Ionomycin results in increased expression of SLC3A2 mRNA			[118]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetradecanoylphorbol Acetate co-treated with Ionomycin results in increased expression of SLC3A2 mRNA			[118]
Regulation Mechanism				Transcription Factor Info
thifluzamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	thifluzamide results in increased expression of SLC3A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Zinc	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC3A2 mRNA			[128]
Regulation Mechanism				Transcription Factor Info

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